Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Russell Hilf"'
Autor:
Russell Hilf
Publikováno v:
Journal of Bioenergetics and Biomembranes. 39:85-89
Photodynamic Therapy (PDT) is an evolving cancer treatment that depends on three known and variable components: photosensitizer, light and oxygen. Optimization of these variables yields reactive oxygen species, mainly singlet oxygen, that damage cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d2d9eb1808644891948f36971da83b
https://doi.org/10.1007/s10863-006-9064-8
https://doi.org/10.1007/s10863-006-9064-8
Autor:
Inge Michel, Robert A. Orlando, Harold Goldenberg, Russell Hilf, Francis L. Archer, Carlton Bell
SummaryIn order to establish valid experimental systems for the study of breast cancer, an examination of the biochemical and morphologic characteristics of transplantable and carcinogen-induced mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b2c4b9d5803b5b6c7632386bd96e196
https://doi.org/10.1159/000388791
https://doi.org/10.1159/000388791
Publikováno v:
Current Drug Targets - Immune, Endocrine & Metabolic Disorders. 5:379-396
The development of breast cancer is the consequence of uncontrolled growth and division of breast-ductal epithelial cells. While many factors contribute to its etiology, estrogen hormones within the context of many interrelated growth signaling pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcba7133b6a0dae9a4dddfd5ba3bf174
https://doi.org/10.2174/156800805774912944
https://doi.org/10.2174/156800805774912944
Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2235-2251
21,23-Dithiaporphyrins (2-10) were designed and prepared as analogues of 5,20-diphenyl-10,15-bis(4-carboxylatomethoxy)phenyl-21,23-dithiaporphyrin (1) to examine the impact of steric bulk at the 5- and 20-meso positions as well as the impact of symme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186b45e7ea5c03f04878654dba4b25cb
https://doi.org/10.1016/j.bmc.2004.12.048
https://doi.org/10.1016/j.bmc.2004.12.048
Publikováno v:
Molecular and Cellular Biology. 24:7681-7694
The effects of estrogens, particularly 17beta-estradiol (E2), are mediated by estrogen receptor alpha (ERalpha) and ERbeta. Upon binding to E2, ERs homo- and heterodimerize when coexpressed. The ER dimer then regulates the transcription of target gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdbc30c4bf1881f98296d3c03c32a64
https://doi.org/10.1128/mcb.24.17.7681-7694.2004
https://doi.org/10.1128/mcb.24.17.7681-7694.2004
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:4625-4631
Tetramethylrosamine and its thio- and seleno- analogues (TMR-O, TMR-S, and TMR-Se, respectively) were examined for their ability to be transported by Pgp into chemo-resistant CR1R12 cells. Verapamil (7 x 10(-6)M) enhanced the uptake of TMR-O and TMR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b793bcd8cececa7fe135e8244bd35407
https://doi.org/10.1016/j.bmc.2004.06.034
https://doi.org/10.1016/j.bmc.2004.06.034
Autor:
Earl J. Bergey, Indrajit Roy, Tymish Y. Ohulchanskyy, Sherry R. Davies, Scott L. Gibson, Youngjae You, Allan R. Oseroff, Michael R. Detty, Russell Hilf
Publikováno v:
Journal of Medicinal Chemistry. 46:3734-3747
Water soluble, core-modified porphyrins 1-5 bearing 1-4 carboxylic acid groups were prepared and evaluated in vitro as photosensitizers for photodynamic therapy. The 21,23-core-modified porphyrins 1-5 gave band I absorption maxima with lambda(max) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802b16a6b2919acc8e9865622b4392de
https://doi.org/10.1021/jm030136i
https://doi.org/10.1021/jm030136i
Publikováno v:
Molecular and Cellular Endocrinology. 192:171-185
Most highly estrogen responsive genes are synergistically activated by multiple copies of estrogen responsive elements (EREs) capable of binding to the estrogen receptor (ER). We examined here the structural features of the receptor necessary to inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c617dc788b57c2a1e262ceba2e356fe
https://doi.org/10.1016/s0303-7207(01)00673-6
https://doi.org/10.1016/s0303-7207(01)00673-6
Autor:
Ping Yi, Sumedha Bhagat, Mesut Muyan, Mark D. Driscoll, Russell Hilf, Jing Huang, Robert A. Bambara
Publikováno v:
Molecular Endocrinology. 16:674-693
Estrogen signaling is mediated by ERα and -β. ERs are converted from an inactive form to a transcriptionally active state through conformational changes induced by ligand and estrogen-responsive element (ERE) sequences. We show here that ERα and E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8dc5c258b0ef50b8164801f157e7ef8
https://doi.org/10.1210/mend.16.4.0810
https://doi.org/10.1210/mend.16.4.0810
Fusion estrogen receptor proteins: toward the development of receptor-based agonists and antagonists
Autor:
Mark D. Driscoll, Ganesan Sathya, Robert A. Bambara, Mesut Muyan, Russell Hilf, Leslie J. Willmert, Ping Yi
Publikováno v:
Molecular and Cellular Endocrinology. 182:249-263
Estrogen-induced signaling mediated by estrogen receptors (ERs) is also affected by aberrant ERs that act as constitutively active or dominant negative modulators. Variant ERs can contribute to carcinogenesis and to the loss of estrogen responsivenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c02372290f3bbdde511d2e495916962
https://doi.org/10.1016/s0303-7207(01)00493-2
https://doi.org/10.1016/s0303-7207(01)00493-2