Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Russell G. Jones"'
Autor:
Hannah Guak, Matthew Weiland, Alexandra Vander Ark, Lukai Zhai, Kin Lau, Mario Corrado, Paula Davidson, Ebenezer Asiedu, Batsirai Mabvakure, Shelby Compton, Lisa DeCamp, Catherine A. Scullion, Russell G. Jones, Sara M. Nowinski, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114506- (2024)
Summary: Functional and phenotypic heterogeneity of dendritic cells (DCs) play crucial roles in facilitating the development of diverse immune responses essential for host protection. Here, we report that KDM5C, a histone lysine demethylase, regulate
Externí odkaz:
https://doaj.org/article/7912e7450a604454a8a5bc93c75f0f1a
Autor:
Zachary B Madaj, Michael S. Dahabieh, Vijayvardhan Kamalumpundi, Brejnev Muhire, J. Pettinga, Rebecca A. Siwicki, Abigail E. Ellis, Christine Isaguirre, Martha L. Escobar Galvis, Lisa DeCamp, Russell G. Jones, Scott A. Givan, Marie Adams, Ryan D. Sheldon
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 186-197 (2023)
Here, we provide an in-depth analysis of the usefulness of single-sample metabolite/RNA extraction for multi-‘omics readout. Using pulverized frozen livers of mice injected with lymphocytic choriomeningitis virus (LCMV) or vehicle (Veh), we isolate
Externí odkaz:
https://doaj.org/article/04874c3865a64c46a4a4eabd9d1a05ee
Autor:
James H. Schofield, Joseph Longo, Ryan D. Sheldon, Emma Albano, Abigail E. Ellis, Mark A. Hawk, Sean Murphy, Loan Duong, Sharif Rahmy, Xin Lu, Russell G. Jones, Zachary T. Schafer
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113984- (2024)
Summary: Targeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not an efficacious strategy in a variety of cancer types, in part due to immunosuppre
Externí odkaz:
https://doaj.org/article/4c7f2836a59b4a5691fa9a3f93e654d9
Autor:
Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophélia Le Thuc, Ismael González-García, Elena García-Clave, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, Cristina García-Cáceres
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113305- (2023)
Summary: Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVNOT n
Externí odkaz:
https://doaj.org/article/90782dfc60ca478ea59744d818a5084b
Autor:
Hannah Guak, Ryan D. Sheldon, Ian Beddows, Alexandra Vander Ark, Matthew J. Weiland, Hui Shen, Russell G. Jones, Julie St-Pierre, Eric H. Ma, Connie M. Krawczyk
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Metabolic programming of the innate immune cells known as dendritic cells (DCs) changes in response to different stimuli, influencing their function. While the mechanisms behind increased glycolytic metabolism in response to inflammatory sti
Externí odkaz:
https://doaj.org/article/6f4583858e0a41b89b2cf4aaa9094f6e
Autor:
Jianping He, Abigail M. Abikoye, Brett P. McLaughlin, Ryan S. Middleton, Ryan Sheldon, Russell G. Jones, Zachary T. Schafer
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106827- (2023)
Summary: Cancer cells often acquire resistance to cell death programs induced by loss of integrin-mediated attachment to extracellular matrix (ECM). Given that adaptation to ECM-detached conditions can facilitate tumor progression and metastasis, the
Externí odkaz:
https://doaj.org/article/1c833519e2d84ddabdda031f3b3875b3
Autor:
Laura E. Mendonca, Erwan Pernet, Nargis Khan, Joaquin Sanz, Eva Kaufmann, Jeffrey Downey, Alexandre Grant, Marianna Orlova, Erwin Schurr, Connie Krawczyk, Russell G. Jones, Luis B. Barreiro, Maziar Divangahi
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Pulmonary macrophages have two distinct ontogenies: long-lived embryonically-seeded alveolar macrophages (AM) and bone marrow-derived macrophages (BMDM). Here, we show that after infection with a virulent strain of Mycobacterium tuberculosis (H37Rv),
Externí odkaz:
https://doaj.org/article/738caedcbb114f40997a13c864c51a29
Autor:
Lucas Stetzik, Gabriela Mercado, Lindsey Smith, Sonia George, Emmanuel Quansah, Katarzyna Luda, Emily Schulz, Lindsay Meyerdirk, Allison Lindquist, Alexis Bergsma, Russell G. Jones, Lena Brundin, Michael X. Henderson, John Andrew Pospisilik, Patrik Brundin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
There is growing evidence for the key role of microglial functional state in brain pathophysiology. Consequently, there is a need for efficient automated methods to measure the morphological changes distinctive of microglia functional states in resea
Externí odkaz:
https://doaj.org/article/1bddc0e28bb347448bdadb55a853f2cb
Autor:
Monika Bambouskova, Lucie Potuckova, Tomas Paulenda, Martina Kerndl, Denis A. Mogilenko, Kate Lizotte, Amanda Swain, Sebastian Hayes, Ryan D. Sheldon, Hyeryun Kim, Unnati Kapadnis, Abigail E. Ellis, Christine Isaguirre, Samantha Burdess, Anwesha Laha, Gaya K. Amarasinghe, Victor Chubukov, Thomas P. Roddy, Michael S. Diamond, Russell G. Jones, Donald M. Simons, Maxim N. Artyomov
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108756- (2021)
Summary: Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activ
Externí odkaz:
https://doaj.org/article/dfbaa470a8684ff5a4d62690f4e0c2bb
Autor:
Said Izreig, Alexandra Gariepy, Irem Kaymak, Hannah R. Bridges, Ariel O. Donayo, Gaëlle Bridon, Lisa M. DeCamp, Susan M. Kitchen-Goosen, Daina Avizonis, Ryan D. Sheldon, Rob C. Laister, Mark D. Minden, Nathalie A. Johnson, Thomas F. Duchaine, Marc S. Rudoltz, Sanghee Yoo, Michael N. Pollak, Kelsey S. Williams, Russell G. Jones
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 2, Pp 100014- (2020)
Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK) p
Externí odkaz:
https://doaj.org/article/d6a25ea75c0340f4b7b742c8469caad8