Výsledky vyhledávání - "Russell E Jacobs"

Akademický článek

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.

Autor: Rosaysela Santos, Shimako Kawauchi, Russell E Jacobs, Martha E Lopez-Burks, Hojae Choi, Jamie Wikenheiser, Benedikt Hallgrimsson, Heather A Jamniczky, Scott E Fraser, Arthur D Lander, Anne L Calof

Publikováno v: PLoS Biology, Vol 14, Iss 9, p e2000197 (2016)

Elucidating the causes of congenital heart defects is made difficult by the complex morphogenesis of the mammalian heart, which takes place early in development, involves contributions from multiple germ layers, and is controlled by many genes. Here,

Externí odkaz: https://doaj.org/article/a35153e1e5d649febbe5a6a1db5ddb10

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Akademický článek

Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats.

Autor: Madelaine Daianu, Russell E Jacobs, Tara M Weitz, Terrence C Town, Paul M Thompson

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145205 (2015)

Diffusion weighted imaging (DWI) is widely used to study microstructural characteristics of the brain. Diffusion tensor imaging (DTI) and high-angular resolution imaging (HARDI) are frequently used in radiology and neuroscience research but can be li

Externí odkaz: https://doaj.org/article/5d5f25e389d644238eb0e31c25a51169

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Akademický článek

Low Dose Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells.

Autor: Naomi S Sta Maria, Samuel R Barnes, Michael R Weist, David Colcher, Andrew A Raubitschek, Russell E Jacobs

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142767 (2015)

Natural killer (NK) cells play a vital antitumor role as part of the innate immune system. Efficacy of adoptive transfer of NK cells depends on their ability to recognize and target tumors. We investigated whether low dose focused ultrasound with mic

Externí odkaz: https://doaj.org/article/ed5c8b8e177b431ea42c9d8f2525a32f

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Akademický článek

Altered reward circuitry in the norepinephrine transporter knockout mouse.

Autor: Joseph J Gallagher, Xiaowei Zhang, F Scott Hall, George R Uhl, Elaine L Bearer, Russell E Jacobs

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e57597 (2013)

Synaptic levels of the monoamine neurotransmitters dopamine, serotonin, and norepinephrine are modulated by their respective plasma membrane transporters, albeit with a few exceptions. Monoamine transporters remove monoamines from the synaptic cleft

Externí odkaz: https://doaj.org/article/e3addf501e644d828fb521464e7237c0

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Akademický článek

Altered neurocircuitry in the dopamine transporter knockout mouse brain.

Autor: Xiaowei Zhang, Elaine L Bearer, Benoit Boulat, F Scott Hall, George R Uhl, Russell E Jacobs

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11506 (2010)

The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine a

Externí odkaz: https://doaj.org/article/5f0de0cfca4047abba45f7a10d9f8589

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Akademický článek

Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains

Autor: Elaine L. Bearer, Christopher S. Medina, Taylor W. Uselman, Russell E. Jacobs

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Neurons project long axons that contact other distant neurons. Neurons in the medial prefrontal cortex project into the limbic system to regulate responses to reward or threat. Diminished neural activity in prefrontal cortex is associated with loss o

Externí odkaz: https://doaj.org/article/e17435b7cd1e44489374586d13b19c84

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Data from Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101

Autor: Russell E. Jacobs, Andrew A. Raubitschek, David Colcher, Daniel Procissi, Hargun Sohi, David Wert, Thomas S.C. Ng

Purpose: Targeted nanotherapies are being developed to improve tumor drug delivery and enhance therapeutic response. Techniques that can predict response will facilitate clinical translation and may help define optimal treatment strategies. We evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5baf68f297c0fe6a6192a9eccc2431
https://doi.org/10.1158/1078-0432.c.6521297

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Supplementary Figure 1 from Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101

Autor: Russell E. Jacobs, Andrew A. Raubitschek, David Colcher, Daniel Procissi, Hargun Sohi, David Wert, Thomas S.C. Ng

PDF file - 64K, Boxplots of cellular proliferation rates for different treatment groups calculated by applying ADC data to a logistic model of tumor growth. Boxplots for (A) control, (B) CRLX101 and (C) CPT-11 animals between day 0/2, day 0/4, day 2/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aba66e39d6a0c706404f519fccb593e
https://doi.org/10.1158/1078-0432.22448078

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Supplementary Table 1 from Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101

Autor: Russell E. Jacobs, Andrew A. Raubitschek, David Colcher, Daniel Procissi, Hargun Sohi, David Wert, Thomas S.C. Ng

PDF file - 74K, P-values of histological comparisons of CRLX101 and CPT-11 cohorts with controls on different days. Statistically significant values are highlighted (p < 0.01, *, p < 0.05, �).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2f0ed6c5bc5e33769d0c837a1c7731
https://doi.org/10.1158/1078-0432.22448069

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