Zobrazeno 1 - 10 of 163 pro vyhledávání: '"Russell E, Jacobs"'
1
Akademický článek
Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains
Autor: Elaine L. Bearer, Christopher S. Medina, Taylor W. Uselman, Russell E. Jacobs
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Neurons project long axons that contact other distant neurons. Neurons in the medial prefrontal cortex project into the limbic system to regulate responses to reward or threat. Diminished neural activity in prefrontal cortex is associated with loss o
Externí odkaz: https://doaj.org/article/e17435b7cd1e44489374586d13b19c84
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2
Akademický článek
The C9ORF72 repeat expansion alters neurodevelopment
Autor: Eric Hendricks, Alicia M. Quihuis, Shu-Ting Hung, Jonathan Chang, Nomongo Dorjsuren, Balint Der, Kim A. Staats, Yingxiao Shi, Naomi S. Sta Maria, Russell E. Jacobs, Justin K. Ichida
Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112983- (2023)
Summary: Genetic mutations that cause adult-onset neurodegenerative diseases are often expressed during embryonic stages, but it is unclear whether they alter neurodevelopment and how this might influence disease onset. Here, we show that the most co
Externí odkaz: https://doaj.org/article/461d2ae4a12545c4b1a169e2bb068ec8
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3
Akademický článek
Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model
Autor: Naomi S. Sta Maria, Leslie A. Khawli, Vyshnavi Pachipulusu, Sharon W. Lin, Long Zheng, Daniel Cohrs, Xiaodan Liu, Peisheng Hu, Alan L. Epstein, Russell E. Jacobs
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Quantitative in vivo monitoring of cell biodistribution offers assessment of treatment efficacy in real-time and can provide guidance for further optimization of chimeric antigen receptor (CAR) modified cell therapy. We evaluated the utility
Externí odkaz: https://doaj.org/article/1a42eddcd18d4b17b25c6a34627d8118
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4
Akademický článek
Evolution of brain-wide activity in the awake behaving mouse after acute fear by longitudinal manganese-enhanced MRI
Autor: Taylor W. Uselman, Daniel R. Barto, Russell E. Jacobs, Elaine L. Bearer
Publikováno v: NeuroImage, Vol 222, Iss , Pp 116975- (2020)
Life threatening fear after a single exposure evolves in a subset of vulnerable individuals to anxiety, which may persist for their lifetime. Yet neither the whole brain's response to innate acute fear nor how brain activity evolves over time is know
Externí odkaz: https://doaj.org/article/11e0bee4b6544f3ba73879b925846f06
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5
Akademický článek
Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain
Autor: Christopher S. Medina, Taylor W. Uselman, Daniel R. Barto, Frances Cháves, Russell E. Jacobs, Elaine L. Bearer
Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)
Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn2+ is decreased. In old transgenic mice expressing
Externí odkaz: https://doaj.org/article/5f4a0df5ea354b38a28986fe4c7b724c
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7
Data from Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101
Autor: Russell E. Jacobs, Andrew A. Raubitschek, David Colcher, Daniel Procissi, Hargun Sohi, David Wert, Thomas S.C. Ng
Purpose: Targeted nanotherapies are being developed to improve tumor drug delivery and enhance therapeutic response. Techniques that can predict response will facilitate clinical translation and may help define optimal treatment strategies. We evalua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5baf68f297c0fe6a6192a9eccc2431
https://doi.org/10.1158/1078-0432.c.6521297
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8
Supplementary Figure 1 from Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101
Autor: Russell E. Jacobs, Andrew A. Raubitschek, David Colcher, Daniel Procissi, Hargun Sohi, David Wert, Thomas S.C. Ng
PDF file - 64K, Boxplots of cellular proliferation rates for different treatment groups calculated by applying ADC data to a logistic model of tumor growth. Boxplots for (A) control, (B) CRLX101 and (C) CPT-11 animals between day 0/2, day 0/4, day 2/
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aba66e39d6a0c706404f519fccb593e
https://doi.org/10.1158/1078-0432.22448078
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10
Supplementary Figure 2 from Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101
Autor: Russell E. Jacobs, Andrew A. Raubitschek, David Colcher, Daniel Procissi, Hargun Sohi, David Wert, Thomas S.C. Ng
PDF file - 112K, Quantitative histological assessment of CRLX101 and CPT-11 response. Tumors treated with CRLX101 (5 mg/kg), CPT-11 (100 mg/kg) or saline were harvested for histology on days 0, 2, 4, and 7. Tumor samples were subsequently sectioned a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b3aa1bb1f72bd5e596b6cd8eb77739
https://doi.org/10.1158/1078-0432.22448075.v1
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