Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Russell C. Smith"'
Autor:
Nils Frank, Jeremy Nugent, Bethany R. Shire, Helena D. Pickford, Patrick Rabe, Alistair J. Sterling, Tryfon Zarganes-Tzitzikas, Thomas Grimes, Amber L. Thompson, Russell C. Smith, Christopher J. Schofield, Paul E. Brennan, Fernanda Duarte, Edward A. Anderson
Publikováno v:
Nature. 611:721-726
Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly-foundpara-substituted benzene rings in drug design1. The utility of these cage structures derives from their superior pharmacokinetic properties compared to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27148d6fff34bca82ee0e073bf600ca9
https://doi.org/10.1038/s41586-022-05290-z
https://doi.org/10.1038/s41586-022-05290-z
Autor:
Helena D, Pickford, Jeremy, Nugent, Benjamin, Owen, James J, Mousseau, Russell C, Smith, Edward A, Anderson
Publikováno v:
Journal of the American Chemical Society. 143(26)
Bicyclo[1.1.1]pentylamines (BCPAs) are of growing importance to the pharmaceutical industry as sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16eb70a2ab8b8844e92f17504b1e416d
https://pubmed.ncbi.nlm.nih.gov/34161076
https://pubmed.ncbi.nlm.nih.gov/34161076
Autor:
Fernanda Duarte, Alistair J. Sterling, Edward A. Anderson, Alexander B. Dürr, Russell C. Smith
Publikováno v:
Chemical Science
[1.1.1]Propellane is the ubiquitous precursor to bicyclo[1.1.1]pentanes (BCPs), motifs of high value in pharmaceutical and materials research. The classical Lewis representation of this molecule places an inter-bridgehead C–C bond along its central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e05336f8901ed4c86d7295098f7343
https://pubmed.ncbi.nlm.nih.gov/34122945
https://pubmed.ncbi.nlm.nih.gov/34122945
Autor:
Kristi A. Leonard, Kevin D. Kreutter, Suzie Kim, Tadimeti S. Rao, Michael C. Harris, Wenying Chai, Tatiana Koudriakova, Paul J. Krawczuk, Russell C. Smith, James P. Edwards, Mark Seierstad, Marguerite E. Johnson, Lisa Madge, Jennifer D. Venable, Gavin C. Hirst, Genesis M. Bacani, Aihua Wang, Ravi Malaviya, Mark S. Tichenor, Michele C. Rizzolio, Ashok S. Mathur
Publikováno v:
Journal of medicinal chemistry. 63(6)
To identify Janus kinase (JAK) inhibitors that selectively target gastrointestinal tissues with limited systemic exposures, a class of imidazopyrrolopyridines with a range of physical properties was prepared and evaluated. We identified compounds wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c7f6dc6bca7939f0adbd0515e0e729
https://pubmed.ncbi.nlm.nih.gov/32134643
https://pubmed.ncbi.nlm.nih.gov/32134643
Autor:
Sisir Karumanchi, Blair Emanuel, Brett Kennedy, Kyle Edelberg, John Koehler, Charles F. Bergh, Jason Carlton, Paul Backes, Jeremy Nash, Rudranarayan Mukherjee, Junggon Kim, Russell C. Smith
Publikováno v:
Journal of Field Robotics. 35:1005-1021
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61303932715fa8f28ec6a58665a15f9c
https://doi.org/10.1002/rob.21792
https://doi.org/10.1002/rob.21792
Autor:
Amanda C. Jones, Brian M. Stoltz, Scott C. Virgil, Robert A. Craig, Jennifer L. Roizen, Russell C. Smith
Publikováno v:
The Journal of Organic Chemistry. 83:3467-3485
An enantioselective and diastereoselective approach toward the synthesis of the tetracyclic scaffold of the furanobutenolide-derived polycyclic norditerpenoids is described. Focusing on synthetic efforts toward ineleganolide, the synthetic approach u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65602792dffa35430a412f17409b4e57
https://doi.org/10.1021/acs.joc.7b02825
https://doi.org/10.1021/acs.joc.7b02825
Publikováno v:
The Journal of Organic Chemistry. 82:13051-13067
Recently, we reported a convergent cyclopropanation–Cope approach to the core of ineleganolide, which was the first disclosed synthesis of the core of the norditerpene natural product ineleganolide. In this complementary work, a model system for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01259a884348b97dd3fd60eaa3d48fa6
https://doi.org/10.1021/acs.joc.7b02030
https://doi.org/10.1021/acs.joc.7b02030
The highly strained caged hydrocarbon [1.1.1]propellane has long fascinated chemists with its seemingly paradoxical stability, yet promiscuous reactivity. In this work, we present a unified model of reactivity that accounts for its omniphilic charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc836601779141acdb53f21c338656f
https://doi.org/10.26434/chemrxiv.9733628.v1
https://doi.org/10.26434/chemrxiv.9733628.v1
Glacial science could benefit tremendously from autonomous robots, but previous glacial robots have had perception issues in these colorless and featureless environments, specifically with visual feature extraction. This translates to failures in vis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795b2fd672699f462a67d65f4cac08cd
http://arxiv.org/abs/1908.10425
http://arxiv.org/abs/1908.10425
Autor:
Brian M. Stoltz, Scott C. Virgil, Amanda C. Jones, Russell C. Smith, Robert A. Craig, Jennifer L. Roizen
Late-stage synthetic efforts to advance the enatio- and diastereoselectively constructed [6,7,5,5]-fused tetracyclic scaffold toward the polycyclic norditerpenoid ineleganolide are disclosed. The described investigations focus on oxidation-state mani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a556d5c88c45ad94a8327c7fc5457154
https://resolver.caltech.edu/CaltechAUTHORS:20190508-090511086
https://resolver.caltech.edu/CaltechAUTHORS:20190508-090511086