Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Russell C. Scaduto"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 286:H731-H741
A sudden increase in the transmural pressure gradient across endothelial monolayers reduces hydraulic conductivity ( Lp), a phenomenon known as the sealing effect. To further characterize this endothelial adaptive response, we measured bovine aortic
Publikováno v:
Glia. 46:183-194
Oligodendroglial death due to overactivation of the AMPA/kainate glutamate receptors is implicated in white matter damage in multiple CNS disorders. We previously demonstrated that glutamate induces caspase-3 activation and death of the late oligoden
Publikováno v:
Journal of Neurochemistry. 80:667-677
Corticosteroids provide an effective treatment to reduce edema for conditions in which the blood-brain or blood-retinal barrier is compromised. However, little is known about the mechanism by which these hormones affect endothelial cell function. We
Autor:
L. W. Grotyohann, Russell C. Scaduto
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 279:H1839-H1848
We used 2,3-butanedione monoxime (BDM) to suppress work by the perfused rat heart and to investigate the effects of calcium on NADH production and tissue energetics. Hearts were perfused with buffer containing BDM and elevated perfusate calcium to ma
Publikováno v:
Journal of Neuroscience Research. 55:674-686
Astrocytes protect neurons and oligodendrocytes by buffering ions, neurotransmitters, and providing metabolic support. However, astrocytes are also vulnerable to oxidative stress, which may affect their protective and supportive functions. This paper
Autor:
Alexander V. Panov, Russell C. Scaduto
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 270:H1398-H1406
Oxidative metabolism in the heart is tightly coupled to mechanical work. Because this coupling process is believed to involve Ca2+, the roles of mitochondrial Ca2+ in the regulation of oxidative phosphorylation was studied in isolated rat heart mitoc
Autor:
Alexander V. Panov, Russell C. Scaduto
Publikováno v:
Archives of Biochemistry and Biophysics. 316:815-820
Physiological increases in matrix calcium are known to stimulate three mitochondrial dehydrogenases. In mitochondria isolated from rat heart, calcium stimulates rates of State 3 respiration during oxidation of succinate and of several NAD-linked subs
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 265:H1203-H1208
A system to perifuse isolated rat heart mitochondria was designed to study the relationship between mitochondrial matrix free Ca2+ and extramitochondrial free Ca2+ under conditions in which the latter concentration could oscillate over a range typica
Autor:
Douglas L. Tillotson, Barbara A. Miller, Russell C. Scaduto, Mary Beth Elensky, Laurie L. Bell, Joseph Y. Cheung, Ulrike Brauneis
Publikováno v:
Journal of Clinical Investigation. 90:1850-1856
To investigate the mechanism of intracellular Ca2+ ([Cai]) increase in human burst-forming unit-erythroid-derived erythroblasts by erythropoietin, we measured [Cai] with digital video imaging, cellular phosphoinositides with high performance liquid c
Autor:
L. W. Grotyohann, Russell C. Scaduto
Publikováno v:
American Journal of Physiology-Renal Physiology. 262:F777-F783
Renal levels of glutathione are markedly decreased during periods of renal ischemia due to catabolism to cysteine. We previously demonstrated that cysteine accumulates in the tissue as the thiol during ischemia, and resumption of blood flow causes a