Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Russell Burley"'
Autor:
Claire E. Hall, Zhi Yao, Minee Choi, Giulia E. Tyzack, Andrea Serio, Raphaelle Luisier, Jasmine Harley, Elisavet Preza, Charlie Arber, Sarah J. Crisp, P. Marc D. Watson, Dimitri M. Kullmann, Andrey Y. Abramov, Selina Wray, Russell Burley, Samantha H.Y. Loh, L. Miguel Martins, Molly M. Stevens, Nicholas M. Luscombe, Christopher R. Sibley, Andras Lakatos, Jernej Ule, Sonia Gandhi, Rickie Patani
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1739-1749 (2017)
Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remain unresolved. Here, we optimized directed differen
Externí odkaz:
https://doaj.org/article/550ea2af177d49298d42a25f23b48e54
Autor:
Bernardino Ossola, Ali Rifat, Anna Rowland, Helen Hunter, Samuel Drinkall, Clare Bender, Mayida Hamlischer, Martin Teall, Russell Burley, Daneil F. Barker, David Cadwalladr, Louise Dickson, Jason M.K. Lawrence, Jenna R.M. Harvey, Marina Lizio, Xiao Xu, Edel Kavanagh, Toni Cheung, Steve Sheardown, Catherine B. Lawrence, Michael Harte, David Brough, Christian Madry, Kim Matthews, Kevin Doyle, Keith Page, Justin Powell, Nicola L. Brice, Roland W. Bürli, Mark B. Carlton, Lee A. Dawson
Publikováno v:
Neuropharmacology. 224
Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence suggests that NLRP3 activation involves changes in intracellular K
Autor:
Russell Burley, Richard C. Hewer, Martin Teall, Louise Dickson, Bernardino Ossola, Sam Russell, Clare Bender, Toni Cheung, Justin A.C. Powell, Xiao Xu, Nicola L. Brice, Lucy Otter, Marta Arimont, Sarah L. Kidd, David Vidal, James W. Dale, Lewis Mervin, Hannah F. Sore, Natalia Mateu, Narayana Lakshminarayana, Lee A. Dawson, Mark Carlton, Roland W. Bürli
Publikováno v:
Bioorganicmedicinal chemistry letters. 61
We report a significant decrease in transcription of the G protein-coupled receptor GPR39 in striatal neurons of Parkinson's disease patients compared to healthy controls, suggesting that a positive modulator of GPR39 may beneficially impact neuropro
Autor:
Victoria J Mulligan, Toni Cheung, Joseph Russo, Nidhi Kaushal, Nicola Brice, Louise Dickson, Darian Bartkowski, Steven A. Sheardown, Lee A. Dawson, Justin Powell, J Russell Burley, Stephen H Hitchcock, Natalie Hosea, Mark Carlton, Hans H Schiffer, Huikai Sun, Yun Chen, Jason Lawrence, Holger Monenschein, Murphy Sean, Anne Kanta, Xiao Xu, Keith Page
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 377(3)
GPR6 is an orphan G-protein–coupled receptor that has enriched expression in the striatopallidal, indirect pathway and medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in
Autor:
Russell Burley, Jenna R. M. Harvey
Publikováno v:
Patch Clamp Electrophysiology ISBN: 9781071608173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7f387ad3d4f814bb4c0d25f7c8c6405
https://doi.org/10.1007/978-1-0716-0818-0_6
https://doi.org/10.1007/978-1-0716-0818-0_6
Autor:
Russell, Burley, Jenna R M, Harvey
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2188
Multielectrode arrays (MEAs) are grids of substrate-integrated microelectrodes that allow for electrophysiological interrogation of dissociated cell cultures or tissue slices. Here we discuss the use of nonimplantable electrodes for studies. The meth
Publikováno v:
Schizophrenia Bulletin. 45:S313-S314
BACKGROUND: TAK-831 is a potent inhibitor of the DAAO enzyme being developed for the cognitive deficits and negative symptoms of schizophrenia. Inhibition of DAAO results in an increase in D-serine, a co-agonist of the NMDA receptor and a full agonis
Autor:
Iain James, Stuart D.C. Ward, Sarah Louise Mellor, Philip J. Birch, Lars J. S. Knutsen, J. Russell Burley, Fiumana Andrea, Jenny Christine Ionix Pharmaceuticals Ltd Gilbert, Nichola Smith, Fleur Radford, Christopher Hobbs, Christopher Geoffrey Earnshaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:662-667
A series of new N-type (Cav2.2) calcium channel blockers derived from the ‘hit’ structures 2-(3-bromo-4-fluorophenyl)-3-(2-pyridin-2-ylethyl)thiazolidin-4-one 9 and its 2-[4-(4-bromophenyl)pyridin-3-yl]-3-isobutyl analogue 10 is described. Extens
Autor:
Caroline Anne Hick, J. Russell Burley, Iain James, Kathryn Elsegood, Sarah Elizabeth Helen Bowden, Lodewijk V. Dekker, Tadge Szestak, Zoe Daniels, Andy Southan, David Cronk
Publikováno v:
European Journal of Pharmacology. 528:52-58
The tetrodotoxin-resistant voltage-gated sodium channel α-subunit Nav1.8 is expressed in nociceptors and has been implicated in chronic pain. Difficulties of heterologous expression have so far precluded analysis of the pharmacological properties of
Autor:
Knutsen, Lars J.S., Hobbs, Christopher J., Earnshaw, Christopher G., Fiumana, Andrea, Gilbert, Jenny, Mellor, Sarah L., Radford, Fleur, Smith, Nichola J., Birch, Philip J., Russell Burley, J., Ward, Stuart D.C., James, Iain F.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2007 17(3):662-667