Výsledky vyhledávání - "Russell C. Smith"

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Autor: Nils Frank, Jeremy Nugent, Bethany R. Shire, Helena D. Pickford, Patrick Rabe, Alistair J. Sterling, Tryfon Zarganes-Tzitzikas, Thomas Grimes, Amber L. Thompson, Russell C. Smith, Christopher J. Schofield, Paul E. Brennan, Fernanda Duarte, Edward A. Anderson

Publikováno v: Nature. 611:721-726

Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly-foundpara-substituted benzene rings in drug design1. The utility of these cage structures derives from their superior pharmacokinetic properties compared to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27148d6fff34bca82ee0e073bf600ca9
https://doi.org/10.1038/s41586-022-05290-z

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Twofold Radical-Based Synthesis of

Autor: Helena D, Pickford, Jeremy, Nugent, Benjamin, Owen, James J, Mousseau, Russell C, Smith, Edward A, Anderson

Publikováno v: Journal of the American Chemical Society. 143(26)

Bicyclo[1.1.1]pentylamines (BCPAs) are of growing importance to the pharmaceutical industry as sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16eb70a2ab8b8844e92f17504b1e416d
https://pubmed.ncbi.nlm.nih.gov/34161076

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Rationalizing the diverse reactivity of [1.1.1]propellane through σ-π-delocalization

Autor: Fernanda Duarte, Alistair J. Sterling, Edward A. Anderson, Alexander B. Dürr, Russell C. Smith

Publikováno v: Chemical Science

[1.1.1]Propellane is the ubiquitous precursor to bicyclo[1.1.1]pentanes (BCPs), motifs of high value in pharmaceutical and materials research. The classical Lewis representation of this molecule places an inter-bridgehead C–C bond along its central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e05336f8901ed4c86d7295098f7343
https://pubmed.ncbi.nlm.nih.gov/34122945

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease

Publikováno v: Journal of medicinal chemistry. 63(6)

To identify Janus kinase (JAK) inhibitors that selectively target gastrointestinal tissues with limited systemic exposures, a class of imidazopyrrolopyridines with a range of physical properties was prepared and evaluated. We identified compounds wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c7f6dc6bca7939f0adbd0515e0e729
https://pubmed.ncbi.nlm.nih.gov/32134643

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Development of a Unified Enantioselective, Convergent Synthetic Approach Toward the Furanobutenolide-Derived Polycyclic Norcembranoid Diterpenes: Asymmetric Formation of the Polycyclic Norditerpenoid Carbocyclic Core by Tandem Annulation Cascade

Autor: Amanda C. Jones, Brian M. Stoltz, Scott C. Virgil, Robert A. Craig, Jennifer L. Roizen, Russell C. Smith

Publikováno v: The Journal of Organic Chemistry. 83:3467-3485

An enantioselective and diastereoselective approach toward the synthesis of the tetracyclic scaffold of the furanobutenolide-derived polycyclic norditerpenoids is described. Focusing on synthetic efforts toward ineleganolide, the synthetic approach u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65602792dffa35430a412f17409b4e57
https://doi.org/10.1021/acs.joc.7b02825

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Model Studies To Access the [6,7,5,5]-Core of Ineleganolide Using Tandem Translactonization–Cope or Cyclopropanation–Cope Rearrangements as Key Steps

Autor: Russell C. Smith, Jennifer L. Roizen, Amanda C. Jones, Brian M. Stoltz, Scott C. Virgil

Publikováno v: The Journal of Organic Chemistry. 82:13051-13067

Recently, we reported a convergent cyclopropanation–Cope approach to the core of ineleganolide, which was the first disclosed synthesis of the core of the norditerpene natural product ineleganolide. In this complementary work, a model system for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01259a884348b97dd3fd60eaa3d48fa6
https://doi.org/10.1021/acs.joc.7b02030

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Straining to React: Delocalization Drives the Stability and Omniphilicity of [1.1.1]propellane

Autor: Fernanda Duarte, Edward A. Anderson, Russell C. Smith, Alistair J. Sterling

The highly strained caged hydrocarbon [1.1.1]propellane has long fascinated chemists with its seemingly paradoxical stability, yet promiscuous reactivity. In this work, we present a unified model of reactivity that accounts for its omniphilic charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dc836601779141acdb53f21c338656f
https://doi.org/10.26434/chemrxiv.9733628.v1

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Improving Visual Feature Extraction in Glacial Environments

Autor: Shoya Higa, Aaron Parness, Steven Morad, Kobus Barnard, Russell C. Smith, Jeremy Nash

Glacial science could benefit tremendously from autonomous robots, but previous glacial robots have had perception issues in these colorless and featureless environments, specifically with visual feature extraction. This translates to failures in vis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795b2fd672699f462a67d65f4cac08cd
http://arxiv.org/abs/1908.10425

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