Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Russell, H Swerdlow"'
Autor:
Jing Tian, Kun Jia, Tienju Wang, Lan Guo, Zhenyu Xuan, Elias K. Michaelis, Russell H. Swerdlow, Alzheimer’s Disease Neuroimaging Initiative, Heng Du
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and genetic risks. Although the role of mitochondrial dysfun
Externí odkaz:
https://doaj.org/article/a34bda56f50e4eb085e3cf1b8b00de17
Autor:
Shengran Wang, Jonathan Greenbaum, Chuan Qiu, Russell H. Swerdlow, Mohammad Haeri, Yun Gong, Hui Shen, Hongmei Xiao, Hongwen Deng
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101337- (2024)
Recent studies have explored the spatial transcriptomics patterns of Alzheimer's disease (AD) brain by spatial sequencing in mouse models, enabling the identification of unique genome-wide transcriptomic features associated with different spatial reg
Externí odkaz:
https://doaj.org/article/45eb13b5068241dfbed3c9676048d340
Autor:
Samuel S. Boyd, Dakota R. Robarts, Khue Nguyen, Maite Villar, Ibtihal M. Alghusen, Manasi Kotulkar, Aspin Denson, Halyna Fedosyuk, Stephen A. Whelan, Norman C.Y. Lee, John Hanover, Wagner B. Dias, Ee Phie Tan, Steven R. McGreal, Antonio Artigues, Russell H. Swerdlow, Jeffrey A. Thompson, Udayan Apte, Chad Slawson
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102060- (2024)
Objective: Pharmacologic or genetic manipulation of O-GlcNAcylation, an intracellular, single sugar post-translational modification, are difficult to interpret due to the pleotropic nature of O-GlcNAc and the vast signaling pathways it regulates. Met
Externí odkaz:
https://doaj.org/article/31c888e58b7d4df9804ebed3402bf348
Autor:
Ibtihal M. Alghusen, Marisa S. Carman, Heather M. Wilkins, Taylor A. Strope, Caleb Gimore, Halyna Fedosyuk, Jad Shawa, Sophiya John Ephrame, Aspin R. Denson, Xiaowan Wang, Russell H. Swerdlow, Chad Slawson
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundThe accumulation of dysfunctional mitochondria is an early feature of Alzheimer’s disease (AD). The impaired turnover of damaged mitochondria increases reactive oxygen species production and lowers ATP generation, leading to cellular toxi
Externí odkaz:
https://doaj.org/article/e7a69d2fee85407ca8f745c2a3cbb26a
Autor:
Matthew K. Taylor, Jeffrey M. Burns, In-Young Choi, Trent J. Herda, Phil Lee, Aaron N. Smith, Debra K. Sullivan, Russell H. Swerdlow, Heather M. Wilkins
Publikováno v:
Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Background Impaired brain bioenergetics is a pathological hallmark of Alzheimer’s disease (AD) and is a compelling target for AD treatment. Patients with AD exhibit dysfunction in the brain creatine (Cr) system, which is integral in mainta
Externí odkaz:
https://doaj.org/article/69cb69366c884bc0acef5ad16e3c9069
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7774 (2024)
DNA strand breaks excessively accumulate in the brains of patients with Alzheimer’s disease (AD). While traditionally considered random, deleterious events, neuron activity itself induces DNA breaks, and these “adaptive” breaks help mediate syn
Externí odkaz:
https://doaj.org/article/c08ee0a30f8147cda698af27da9b367d
Autor:
Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Chad Slawson
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and
Externí odkaz:
https://doaj.org/article/64bc9d124ca94505adb7f3cd937a4c1c
Autor:
Ranu Pal, Dongwei Hui, Heather Menchen, Huiping Zhao, Olivier Mozziconacci, Heather Wilkins, Brian S. J. Blagg, Christian Schöneich, Russell H. Swerdlow, Mary L. Michaelis, Elias K. Michaelis
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
A feature of most neurodegenerative diseases is the presence of “mis-folded proteins” that form aggregates, suggesting suboptimal activity of neuronal molecular chaperones. Heat shock protein 90 (Hsp90) is the master regulator of cell responses t
Externí odkaz:
https://doaj.org/article/5aeb2462e3fd4a9d87dd8dfe62c1225c
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Mitochondria are critical for neurophysiology, and mitochondrial dysfunction constitutes a characteristic pathology in both brain aging and Alzheimer disease (AD). Whether mitochondrial deficiency in brain aging and AD is mechanistically linked, howe
Externí odkaz:
https://doaj.org/article/1f5c1d7ba363421aa5d4a37986a21b89
Autor:
Kaitlin Flannagan, Julia A. Stopperan, Brittany M. Hauger, Benjamin R. Troutwine, Colton R. Lysaker, Taylor A. Strope, Vivien Csikos Drummond, Caleb A. Gilmore, Natalie A. Swerdlow, Julia M. Draper, Cynthia M. Gouvion, Jay L. Vivian, Mohammad Haeri, Russell H. Swerdlow, Heather M. Wilkins
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionMitochondrial dysfunction is observed in Alzheimer’s disease (AD). Altered mitochondrial respiration, cytochrome oxidase (COX) Vmax, and mitophagy are observed in human subjects and animal models of AD. Models derived from induced pluri
Externí odkaz:
https://doaj.org/article/127198d0d9af4585a86ea509bb550673