Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Russ Ellis"'
Publikováno v:
Clinical & Experimental Allergy. 41:1456-1467
Summary Background The syndrome of allergic asthma features reversible bronchoconstriction, airway inflammation and hyperresponsiveness as well as airway remodelling, including goblet cell hyperplasia. Managing severe asthma is still a clinical chall
Publikováno v:
International Journal of Toxicology. 30:244-252
Many women are unable to quit smoking during pregnancy and therefore are prescribed drugs, including nicotine (nicotine replacement therapy [NRT]), to aid with smoking cessation. However, the consequences to the offspring of pregnant NRT users have n
Autor:
Russ Ellis, Åke Ryrfeldt, Mark D. Inman, Gunnar Nilsson, Linda Swedin, Sven-Erik Dahlén, Mikael Adner, Theresa Neimert-Andersson
Publikováno v:
Prostaglandins & Other Lipid Mediators. 92:44-53
As adjuvant during sensitization may cause unspecific immune reactions, the aim of the present study was to define the role of cyclooxygenase (COX) activity on airway inflammation and airway hyperresponsiveness (AHR) in an adjuvant-free allergic mous
Autor:
Y.-Y. Xiang, Alison L. Budelsky, Russ Ellis, B. Lipsky, Jeremy A. Hirota, Wei-Yang Lu, Dirk E. Smith, Mark D. Inman
Publikováno v:
Clinical & Experimental Allergy. 40:820-830
Background Asthma is a disease characterized by airway inflammation, remodelling and dysfunction. Airway inflammation contributes to remodelling, a term that is used to describe structural changes including goblet cell metaplasia (GCM), matrix deposi
Autor:
Mikael Adner, Linda Swedin, Åke Ryrfeldt, Sven-Erik Dahlén, Mark D. Inman, Cecilia Kemi, Russ Ellis
Publikováno v:
International Archives of Allergy and Immunology. 153:249-258
Background: The aim was to optimize antigen challenge for induction of airway hyperresponsiveness (AHR) and inflammation in BALB/c mice sensitized to ovalbumin (OVA). Comparisons were made between mice challenged with OVA either as an aerosol or intr
Publikováno v:
European Respiratory Journal. 32:970-978
Despite the effectiveness of corticosteroids at resolving airway inflammation, they are only moderately effective at attenuating airway hyperresponsiveness (AHR). The extent to which corticosteroids are able to reverse or inhibit the development of s
Publikováno v:
European Respiratory Journal. 31:532-538
Asthma is characterised by an excessive airway narrowing in response to a variety of stimuli, called airway hyperresponsiveness (AHR). Previous comparisons between mouse strains have shown that increased velocity of airway narrowing correlates with b
Autor:
Mohammed Panju, Gail E. M. Martin, Jennifer Wattie, Richard Leigh, Russ Ellis, Mark D. Inman, Mary Jo Smith, Margaret M. Kelly, Philippe Bonniaud, Jack Gauldie
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 32:99-107
Airway remodeling, including subepithelial fibrosis, is a characteristic feature of asthma and likely contributes to the pathogenesis of airway hyperresponsiveness. We examined expression of genes related to airway wall fibrosis in a model of chronic
Publikováno v:
Journal of Allergy and Clinical Immunology. 115:95-102
There is increasing evidence that hemopoietic progenitor cells may traffic from bone marrow to sites of allergen exposure in asthma and undergo in situ differentiation, contributing to ongoing airway inflammation. However, the isolation and detailed
Autor:
Jennifer Wattie, Richard Leigh, Roma Sehmi, Russ Ellis, David S. Southam, Yonghong Wan, Mark D. Inman
Publikováno v:
Journal of Applied Physiology. 97:2258-2265
T-cell-mediated airway inflammation is considered to be critical in the pathogenesis of airway hyperresponsiveness (AHR). We have described a mouse model in which chronic allergen exposure results in sustained AHR and aspects of airway remodeling and