Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Ruslan I. Sadreyev"'
Autor:
Yufeng Wang, David L. Drum, Ruochuan Sun, Yida Zhang, Feng Chen, Fengfei Sun, Emre Dal, Ling Yu, Jingyu Jia, Shahrzad Arya, Lin Jia, Song Fan, Steven J. Isakoff, Allison M. Kehlmann, Gianpietro Dotti, Fubao Liu, Hui Zheng, Cristina R. Ferrone, Alphonse G. Taghian, Albert B. DeLeo, Marco Ventin, Giulia Cattaneo, Yongxiang Li, Youssef Jounaidi, Peigen Huang, Cristina Maccalli, Hanyu Zhang, Cheng Wang, Jibing Yang, Genevieve M. Boland, Ruslan I. Sadreyev, LaiPing Wong, Soldano Ferrone, Xinhui Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target antig
Externí odkaz:
https://doaj.org/article/cdd6a0e581e24892b09297cc99e43a32
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107995- (2023)
Summary: Postnatal acquisition of the microbiome is critical to infant health. In preterm infants, empiric use of antibiotics is common, with significant health consequences. To understand the influence of antibiotics on acquisition of the microbiome
Externí odkaz:
https://doaj.org/article/da2a85896d8e40c9a72a34ec4a65e12a
Autor:
Chih-Chung Jerry Lin, Fanny Herisson, Hoang Le, Nader Jaafar, Kashish Chetal, Mary K. Oram, Kelly L. Flynn, Evan P. Gavrilles, Ruslan I. Sadreyev, Felipe L. Schiffino, Rudolph E. Tanzi
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113141- (2023)
Summary: Emerging evidence suggests that peripheral immune cells contribute to Alzheimer’s disease (AD) neuropathogenesis. Among these, mast cells are known for their functions in allergic reactions and neuroinflammation; however, little is known a
Externí odkaz:
https://doaj.org/article/ebc21dd290af4b188e93315e9f2e49f6
Autor:
Myung‐Ho Kim, Mi‐Young Kim, Shadi Salloum, Tongqi Qian, Lai Ping Wong, Min Xu, Yoojin Lee, Stuti G. Shroff, Ruslan I. Sadreyev, Kathleen E. Corey, Thomas F. Baumert, Yujin Hoshida, Raymond T. Chung
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2581-2593 (2022)
Abstract Lipophilic but not hydrophilic statins have been shown to be associated with reduced risk for hepatocellular carcinoma (HCC) in patients with chronic viral hepatitis. We investigated differential actions of lipophilic and hydrophilic statins
Externí odkaz:
https://doaj.org/article/40cf497b78c3424da7b5b2059d8f1041
Autor:
Chi Zhu, Justin Y. Lee, Jia Z. Woo, Lei Xu, Xammy Nguyenla, Livia H. Yamashiro, Fei Ji, Scott B. Biering, Erik Van Dis, Federico Gonzalez, Douglas Fox, Eddie Wehri, Arjun Rustagi, Benjamin A. Pinsky, Julia Schaletzky, Catherine A. Blish, Charles Chiu, Eva Harris, Ruslan I. Sadreyev, Sarah Stanley, Sakari Kauppinen, Silvi Rouskin, Anders M. Näär
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Despite approved vaccines and anti-virals to prevent and treat SARS-CoV-2 infection, there is a need for further development of efficient antiviral therapeutic strategy. Here, Zhu et al. develop locked nucleic acid antisense oligonucleotides (LNA ASO
Externí odkaz:
https://doaj.org/article/465980a86b3646a5914f997d2bfea608
Autor:
Sung-Hee Yoon, Mark B. Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S. Wang, Christian D. Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A. Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B. Sundberg, Ramnik J. Xavier, Charles H. Adelmann, Daniel J. Brooks, Anthony Anselmo, Ruslan I. Sadreyev, Ivy A. Rosales, David E. Fisher, Navin Gupta, Ryuji Morizane, Anna Greka, J. Wesley Pike, Michael Mannstadt, Marc N. Wein
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated
Externí odkaz:
https://doaj.org/article/807eb29db7bc4680b7215fddd31857a3
Autor:
Reuben Franklin, Yiming Guo, Shiyang He, Meijuan Chen, Fei Ji, Xinyue Zhou, David Frankhouser, Brian T. Do, Carmen Chiem, Mihyun Jang, M. Andres Blanco, Matthew G. Vander Heiden, Russell C. Rockne, Maria Ninova, David B. Sykes, Konrad Hochedlinger, Rui Lu, Ruslan I. Sadreyev, Jernej Murn, Andrew Volk, Sihem Cheloufi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differ
Externí odkaz:
https://doaj.org/article/92b1277f52324a2d9ee446b86d5f55dd
Autor:
Carlos Sebastian, Christina Ferrer, Maria Serra, Jee-Eun Choi, Nadia Ducano, Alessia Mira, Manasvi S. Shah, Sylwia A. Stopka, Andrew J. Perciaccante, Claudio Isella, Daniel Moya-Rull, Marianela Vara-Messler, Silvia Giordano, Elena Maldi, Niyati Desai, Diane E. Capen, Enzo Medico, Murat Cetinbas, Ruslan I. Sadreyev, Dennis Brown, Miguel N. Rivera, Anna Sapino, David T. Breault, Nathalie Y. R. Agar, Raul Mostoslavsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Metabolic reprogramming upon SIRT6 loss induces tumour formation in the intestine but the mechanism is unclear. Here, the authors show that loss of SIRT6 leads to the expansion of epithelial cells with high pyruvate dehydrogenase kinase activity resu
Externí odkaz:
https://doaj.org/article/1ae650e5a5c942e78cc7775f36dd9685
Autor:
Ying Zhu, Rui Wang, Anthony C. Pappas, Philip Seifert, Andrej Savol, Ruslan I. Sadreyev, Daniel Sun, Tatjana C. Jakobs
Publikováno v:
Cells, Vol 12, Iss 17, p 2131 (2023)
The optic nerve head is thought to be the site of initial injury to retinal ganglion cell injury in glaucoma. In the initial segment of the optic nerve directly behind the globe, the ganglion cell axons are unmyelinated and come into direct contact t
Externí odkaz:
https://doaj.org/article/d4920632313243e9949ed91015fa5d42
Autor:
Sarah E. Williams, Maxence Noel, Sylvain Lehoux, Murat Cetinbas, Ramnik J. Xavier, Ruslan I. Sadreyev, Edward M. Scolnick, Jordan W. Smoller, Richard D. Cummings, Robert G. Mealer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Protein glycosylation is critical in brain development and disease. Here, the authors characterize brain glycans in detail, showing that they are simpler and more homogenous than glycans from other tissues and providing a basis for future studies of
Externí odkaz:
https://doaj.org/article/fd0184e422b34b0fa0c85d132ae52c42