Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ruslan Grygorash"'
Autor:
Nick Evans, Ruslan Grygorash, Paul Williams, Andrew Kyle, Terrence Kantner, Ravindra Pathak, XiaoBo Sheng, Fabio Simoes, Hiteshri Makwana, Ricardo Resende, Elena de Juan, Alan Jenkins, David Morris, Aurelie Michelet, Frances Jewitt, Felicity Rudge, Nicolas Camper, Anaïs Manin, William McDowell, Martin Pabst, Antony Godwin, Mark Frigerio, Matthew Bird
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field matures, much attention has focused upon the key factors required to produce safe and efficacious ADC
Externí odkaz:
https://doaj.org/article/e322c470d7fb4d25b6de4ac481fa6602
Autor:
Jiawei Sun, Pingyu Ding, Duncton Matthew A J, Zhi-Jie Ni, Ruslan Grygorash, Guijun Yu, Longwu Qi, Brian J Wang, Xianfeng Li, Eric M. Gordon, Dazhong Fan, Eddy Low
Publikováno v:
ACS Med Chem Lett
[Image: see text] Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffbd7d2d5a5ccae1b375ffbf4fa6355
https://doi.org/10.1021/acsmedchemlett.9b00534
https://doi.org/10.1021/acsmedchemlett.9b00534
Autor:
Nick, Evans, Ruslan, Grygorash, Paul, Williams, Andrew, Kyle, Terrence, Kantner, Ravindra, Pathak, XiaoBo, Sheng, Fabio, Simoes, Hiteshri, Makwana, Ricardo, Resende, Elena, de Juan, Alan, Jenkins, David, Morris, Aurelie, Michelet, Frances, Jewitt, Felicity, Rudge, Nicolas, Camper, Anaïs, Manin, William, McDowell, Martin, Pabst, Antony, Godwin, Mark, Frigerio, Matthew, Bird
Publikováno v:
Frontiers in pharmacology. 13
Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field matures, much attention has focused upon the key factors required to produce safe and efficacious ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0c163869b09e4c7d83d87923217ec72
https://pubmed.ncbi.nlm.nih.gov/35784686
https://pubmed.ncbi.nlm.nih.gov/35784686
Autor:
William McDowell, Julia Swierkosz, George Badescu, Andrew F. Kyle, Mark Frigerio, Amrita Abhilash, Ji-Won Choi, Estera Jamieson, Matthew P. Baker, XiaoBo Sheng, Matthew Bird, Penny Bryant, Ruslan Grygorash, Katarzyna Kozakowska, Korinna Henseleit, Rita Tommasi, Vimal Parekh, Kosma Jurlewicz, Karolina Peciak, Emmanuelle Laurine, Martin Pabst, Nicolas Camper, Antony Godwin, Anaïs Manin, Jeff Edwards, David Morris
Publikováno v:
Molecular Pharmaceutics. 12:1872-1879
The conjugation of monomethyl auristatin E (MMAE) to trastuzumab using a reduction bis-alkylation approach that is capable of rebridging reduced (native) antibody interchain disulfide bonds has been previously shown to produce a homogeneous and stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdafeb6a27047bdb000238cba2a009a
https://doi.org/10.1021/acs.molpharmaceut.5b00116
https://doi.org/10.1021/acs.molpharmaceut.5b00116
Autor:
Korinna Henseleit, Mark Frigerio, Antony Godwin, Jeff Edwards, XiaoBo Sheng, Matthew Bird, Martin Fisher, Kosma Jurlewicz, George Badescu, Amrita Abhilash, Penny Bryant, Estera Pawlisz, Ruslan Grygorash, Julia Swierkosz, Andrew F. Kyle, Monika Farys, Nicolas Camper, Vimal Parekh, Rita Tommasi
Publikováno v:
Bioconjugate Chemistry. 25:1124-1136
To improve both the homogeneity and the stability of ADCs, we have developed site-specific drug-conjugating reagents that covalently rebridge reduced disulfide bonds. The new reagents comprise a drug, a linker, and a bis-reactive conjugating moiety t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e41ca810ded9c08bfb53bf05fccd1
https://doi.org/10.1021/bc500148x
https://doi.org/10.1021/bc500148x
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 23(19)
Langmuir−Blodgett deposition of a single monolayer of 1,2,4,5-tetrakis[(N-(perfluoroundecanoamidoethyl)-N,N-dimethylammonium)methyl]benzene tetrabromide (1) onto a thin film made from alternating layers of poly(diallydimethylammonium chloride) (PDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c73f071c8f4f03279e9164ca3330469
https://pubmed.ncbi.nlm.nih.gov/17696374
https://pubmed.ncbi.nlm.nih.gov/17696374
Publikováno v:
Journal of the American Chemical Society. 129(27)
Permeation measurements have been made for He, CO2, and N2 across single Langmuir-Blodgett (LB) bilayers derived from 1,2,4,5-tetrakis[(N-(undecanoamidoethyl)-N,N-dimethyl ammonium) methyl]benzene tetrabromide (2) and 1,2,4,5-tetrakis[(N-(perfluoroun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085d560d5135aacb7576238be27bddff
https://pubmed.ncbi.nlm.nih.gov/17571889
https://pubmed.ncbi.nlm.nih.gov/17571889
Publikováno v:
Langmuir; Sep2007, Vol. 23 Issue 19, p9606-9610, 5p
Publikováno v:
Journal of the American Chemical Society. 7/11/2007, Vol. 129 Issue 27, p8663-8667. 5p. 1 Chart, 4 Graphs.