Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rushith Kumar Anumula"'
Autor:
Alaric J Dyckman, John Macor, Stefan Ruepp, Schieven Gary, Shailesh Dudhgaonkar, Satyanaraya Reddy BhimiReddy, Srinath Subramaniam, Arvind Mathur, David Critton, Shana Posy, Rushith Kumar Anumula, Raju Barre, Anupama Reddy, Subramanya Hegde, Pasunoori Laxman, Sreekantha Ratna Kumar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf908c9b46738203425be417fe9b3c6
https://doi.org/10.1021/scimeetings.2c00255
https://doi.org/10.1021/scimeetings.2c00255
Autor:
Nicholas A. Meanwell, Ravi Kumar Trivedi, Tatyana Zvyaga, Richard Rampulla, Sarkunam Kandhasamy, Debarati Mazumder Tagore, Sureshbabu Vishwakrishnan, Arvind Mathur, Sunitha Puttaswamy, Abhijith Rao, Hua Fang, Sankar Sivaprasad, Susan Jenkins, Eric Mull, Kathy Mosure, Kaushik Ghosh, Barbara Zheng, Subba Reddy, Fiona McPhee, Chaoqun Chen, Bowsher Michael S, James Loy, Ying-Kai Wang, Amit Kumar, Ramkumar Rajamani, Kishore Rendunchintala, Paul Michael Scola, Gillis Eric P, Salil D. Desai, Li-Qiang Sun, Rushith Kumar Anumula, Nagalakshmi Pulicharla, Sheldon Hiebert, Venkata Rao Baratam, Paul Falk, Sarmistha Sinha, Stanley D'andrea
Publikováno v:
Journal of Medicinal Chemistry. 63:14740-14760
The discovery of a pan-genotypic hepatitis C virus (HCV) NS3/4A protease inhibitor based on a P1–P3 macrocyclic tripeptide motif is described. The all-carbon tether linking the P1–P3 subsites of 21...
Autor:
Alaric J Dyckman, John Macor, Stefan Ruepp, Gary Leonard Schieven, Shailesh Dudhgaonkar, Satyanaraya Reddy BhimiReddy, Mushkin Basha, Ananta Karmakar, Arvind Mathur, David Critton, Shana Posy, Ramesh Sistla, Rushith Kumar Anumula, Anupama KR Reddy, Vikram Bhogadi, Srinivas Pitani, Ratna K. Sreekantha, Laxman Pasunoori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336f946f4a2474d3af406bf065f5e3bc
https://doi.org/10.1021/scimeetings.2c00064
https://doi.org/10.1021/scimeetings.2c00064
Autor:
Pancras C. Wong, Ruth R. Wexler, Xiaojun Zhang, Joseph M. Luettgen, Alan R. Rendina, Anzhi Wei, Swanee Jacutin-Porte, Robert M. Knabb, Jiang Wen, Gang Luo, Timothy M. Harper, Xuhong Cheng, Peter W. Glunz, Yan Zou, Rushith Kumar Anumula, E. Scott Priestley, Daniel L. Cheney, Alexandra H. Nirschl, Nicholas R. Wurtz
Publikováno v:
ACS Medicinal Chemistry Letters. 5:188-192
Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine
Autor:
Mark R. Harpel, Carolyn A. Weigelt, Pancras C. Wong, Rushith Kumar Anumula, Xuhong Cheng, Anzhi Wei, Xiaojun Zhang, Alan R. Rendina, Delucca Indawati, Guanglin Luo, Ruth R. Wexler, Peter W. Glunz, Robert M. Knabb, Eldon Scott Priestley, Yan Zou, Joseph M. Luettgen, Alexandra H. Nirschl, Daniel L. Cheney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5244-5248
Aminoisoquinoline and isoquinoline groups have successfully replaced the more basic P1 benzamidine group of an acylsulfonamide factor VIIa inhibitor. Inhibitory activity was optimized by the identification of additional hydrophobic and hydrophilic P
Autor:
Thangavelu Matan, Rushith Kumar Anumula, Debarati Mazumder Tagore, Basanth Lakshmaiah, Kaushik Ghosh, Manjunath Ramarao, Senthuran Singaram, Sanjith Kallipatti, Sabariya Selvam, P.P.B.S. Kumar, Prasad Krishnamurthy
Publikováno v:
Journal of structural biology. 184(2)
Intestinal alkaline phosphatases (IAPs) are involved in the cleavage of phosphate prodrugs to liberate the drug for absorption in the intestine. To facilitate in vitro characterization of phosphate prodrugs, we have cloned, expressed, purified and ch
Autor:
Karen S. Hartl, Steven M. Seiler, Guohua Zhao, William A. Slusarchyk, Eddie C.-K. Liu, Daniel L. Cheney, James Sutton, Robert Zahler, Rebecca A. Smirk, Scott A. Bolton, Steven Sheriff, Rushith Kumar Anumula, Zulan Pi, Jacobson Bruce L, Gregory S. Bisacchi, William A. Schumacher, Shung C. Wu, Treuner Uwe D, Sharon N. Bisaha, Anzhi Wei
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(18)
In this Letter, we describe the synthesis of several nonamidine analogs of biaryl acid factor VIIa inhibitor 1 containing weakly basic or nonbasic P1 groups. 2-Aminoisoquinoline was found to be an excellent surrogate for the benzamidine group (compou