Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rushika C. Wirasinha"'
Autor:
Christopher Szeto, Pirooz Zareie, Rushika C. Wirasinha, Justin B. Zhang, Andrea T. Nguyen, Alan Riboldi-Tunnicliffe, Nicole L. La Gruta, Stephanie Gras, Stephen R. Daley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Differentiation and activation of T cells are normally modulated by non-covalent interactions between T cell receptor (TCR) and antigenic peptides. Here the authors use step-wise mutations, biochemical characterization and structural insights to desc
Externí odkaz:
https://doaj.org/article/7e92a31da92d45c4ae21ba3f6d5114af
Autor:
Thomas Barthlott, Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H. Orkin, Jean-Pierre de Villartay, Stephen R. Daley, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configura
Externí odkaz:
https://doaj.org/article/bea5fbe30e2340e383f4864410b7a2fd
Autor:
Rushika C. Wirasinha, Hong Ying Teh, Adam E. Handel, Stephen R. Daley, Benoit Roch, Saulius Žuklys, Stuart H. Orkin, Thomas Barthlott, Jean-Pierre de Villartay, Katrin Hafen, Georg A. Holländer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Thymic T cell development and T cell receptor repertoire selection are dependent on essential molecular cues provided by thymic epithelial cells (TEC). TEC development and function are regulated by their epigenetic landscape, in which the repressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9e2439df69c3a497fbd82be6559f2d
https://doi.org/10.1038/s41467-021-24158-w
https://doi.org/10.1038/s41467-021-24158-w
Autor:
Stephen R. Daley, Christopher C. Goodnow, Daniel Y. Hu, Charis E Teh, Jin Yan Yap, Daniel H.D. Gray, Rushika C. Wirasinha, Anna Chan
Publikováno v:
Cell Death Differ
The selection of αβ T cells in the thymus is punctuated by checkpoints at which thymocytes differentiate or undergo apoptosis. Wave 1 deletion is defined as apoptosis within nascent αβ T-cell antigen receptor (TCR)-signalled thymocytes that lack
Autor:
Stephen J. Turner, Rushika C. Wirasinha, Raelene J. Grumont, Colby Zaph, Stephen R. Daley, Ulf Klein, Thomas S. Fulford, David R. Powell, Steve Gerondakis, Sebastian Scheer, Paul A. Lyons, Kenneth G. C. Smith, Adele Barugahare, Darcy Ellis, Haroon Naeem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3020e74dfbb73b396fe8df7f7023c485
https://doi.org/10.1002/eji.202048900/v2/response1
https://doi.org/10.1002/eji.202048900/v2/response1
Autor:
Colby Zaph, David R. Powell, Paul A. Lyons, Thomas S Fulford, Sebastian Scheer, Kenneth G. C. Smith, Rushika C. Wirasinha, Raelene J. Grumont, Stephen R. Daley, Steve Gerondakis, Haroon Naeem, Ulf Klein, Stephen J. Turner, Darcy P. Ellis, Adele Barugahare
Publikováno v:
European journal of immunologyReferences. 51(8)
The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple points of the stepwise developmental pathway. Here, we found that the thymic Treg defect in c-Rel-deficient (cRel-/- ) mice is quantitative, not qual
Autor:
Graeme J. Stewart, Grant P Parnell, Dipti Vijayan, Alexander Swarbrick, Nicola J. Smith, David R. Booth, Robert Brink, Rushika C. Wirasinha, Cecile King, Marcel Batten
Publikováno v:
Immunology and Cell Biology. 96:128-136
The G protein-coupled receptor 65 (GPR65) gene has been genetically associated with several autoimmune diseases, including multiple sclerosis (MS). GPR65 is predominantly expressed in lymphoid organs and is activated by extracellular protons. In this
Autor:
Dale I. Godfrey, Jared H. Rowe, Julie E. Niemela, Ottavia M. Delmonte, Jennifer Stoddard, Marita Bosticardo, Rushika C. Wirasinha, Stephen R. Daley, Yu Nee Lee, Sevgi Keles, Steven M. Holland, Hui-Fern Koay, Kerry Dobbs, Valentina Capo, Pietro Luigi Poliani, Anna Villa, Francesca Pala, Debbie Draper, Luigi D. Notarangelo, Lisa Ott de Bruin, Sergio D. Rosenzweig, Raz Somech, Riccardo Castagnoli, Sandra Maxwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5d1bae9673155080b13b35ca1ae38a
https://europepmc.org/articles/PMC6675456/
https://europepmc.org/articles/PMC6675456/
Autor:
Cindy S. Ma, Rushika C. Wirasinha, Cecile King, Stephen Adelstein, Nico Ghilardi, Melanie Wong, Dipti Vijayan, Robert Brink, Michael Elliott, Danielle T. Avery, Norhanani Mohd Redzwan, Carola G. Vinuesa, Masao Kobayashi, Paul W Gray, Stuart G. Tangye, Giles Walters, Marcel Batten
Publikováno v:
The Journal of Immunology. 197:3008-3017
Germinal centers (GC) give rise to high-affinity and long-lived Abs and are critical in immunity and autoimmunity. IL-27 supports GCs by promoting survival and function of T follicular helper cells. We demonstrate that IL-27 also directly enhances GC
Autor:
Debbie R. Howard, Stephen R. Daley, Rushika C. Wirasinha, Jin Yan Yap, Anna Chan, Christopher C. Goodnow
Acquisition of T‐cell central tolerance involves distinct pathways of self‐antigen presentation to thymocytes. One pathway termed indirect presentation requires a self‐antigen transfer step from thymic epithelial cells (TECs) to bone marrow‐d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c921d0ad4016686c5979c3f8fdbef6a2
https://europepmc.org/articles/PMC6002238/
https://europepmc.org/articles/PMC6002238/