Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rushendhiran Kesavan"'
Autor:
Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers. Here, the authors show that purine depletion induces s
Externí odkaz:
https://doaj.org/article/e65828f4fe7b450899c62fcdaa40754f
Autor:
Prathap Reddy Kallamadi, Deepshika Esari, Utkarsh Reddy Addi, Rushendhiran Kesavan, Uday Kumar Putcha, Siddavaram Nagini, Geereddy Bhanuprakash Reddy
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11441 (2023)
Patients with comorbidities of obesity and diabetes are recognized to be at high risk of breast cancer development and face worse breast cancer outcomes. Though several reports showed the reinforced link between obesity, diabetes, and prediabetes wit
Externí odkaz:
https://doaj.org/article/2c929b85384c4c45893d96d5023f7b47
Autor:
Rushendhiran Kesavan, Timo Frömel, Sven Zukunft, Bernhard Brüne, Andreas Weigert, Ilka Wittig, Rüdiger Popp, Ingrid Fleming
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7120 (2021)
Epoxides and diols of polyunsaturated fatty acids (PUFAs) are bioactive and can influence processes such as tumor cell proliferation and angiogenesis. Studies with inhibitors of the soluble epoxide hydrolase (sEH) in animals overexpressing cytochrome
Externí odkaz:
https://doaj.org/article/b1951c32495744e4a58cced46e832a39
Autor:
Rushendhiran Kesavan, Uma Rani Potunuru, Branislav Nastasijević, Avaneesh T, Gordana Joksić, Madhulika Dixit
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61393 (2013)
Gentiana lutea belonging to the Gentianaceae family of flowering plants are routinely used in traditional Serbian medicine for their beneficial gastro-intestinal and anti-inflammatory properties. The aim of the study was to determine whether aqueous
Externí odkaz:
https://doaj.org/article/c44c38d840924a559e0a596ac5a8f24c
Autor:
Zhenkang Chen, Bogdan Bordieanu, Rushendhiran Kesavan, Nicholas P. Lesner, Siva Sai Krishna Venigalla, Spencer D. Shelton, Ralph J. DeBerardinis, Prashant Mishra
Publikováno v:
Science Advances. 9
Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have been extensively studied in culture, little in vivo data are available. Using a mouse model
Autor:
Halie Rion, Ralph J. DeBerardinis, Diem Hong Tran, Mona Hoseini Soflaee, Rushendhiran Kesavan, Hieu Sy Vu, John A. Phillips, Divya Bezwada, Gerta Hoxhaj, Feng Cai, Ashley Solmonson
Publikováno v:
Nature Metabolism. 3:571-585
Nicotinamide adenine dinucleotide phosphate (NADP+) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress. NADPH exists in separate pools, in both the cytosol and
Autor:
Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G. Zacharias, Thomas P. Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj
Publikováno v:
Molecular Cell
Molecular Cell, In press, 82 (17), pp.3299-3311.e8. ⟨10.1016/j.molcel.2022.06.026⟩
Molecular Cell, In press, 82 (17), pp.3299-3311.e8. ⟨10.1016/j.molcel.2022.06.026⟩
Submitted document; International audience; NAD+ kinases (NADKs) are metabolite kinases that phosphorylate NAD+ molecules to make NADP+, a limiting substrate for the generation of reducing power NADPH. NADK2 sustains mitochondrial NADPH production th
Publikováno v:
Cell Metab
The emergence of cancer from diverse normal tissues is thought to be governed by a common set of fundamental processes. However, these processes are not fully defined. Here, we show that forced expression of glucose-6-phosphate dehydrogenase (G6PD) a
Autor:
Diem H, Tran, Rushendhiran, Kesavan, Halie, Rion, Mona Hoseini, Soflaee, Ashley, Solmonson, Divya, Bezwada, Hieu S, Vu, Feng, Cai, John A, Phillips, Ralph J, DeBerardinis, Gerta, Hoxhaj
Publikováno v:
Nat Metab
Nicotinamide adenine dinucleotide phosphate (NADP(+)) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress. NADPH exists in separate pools, in both the cytosol an
Autor:
Alexandra Geyer, Eiman Elwakeel, Ilka Wittig, Ingrid Fleming, Andreas Weigert, Bernhard Brüne, Timo Frömel, Juliana Heidler, Zumer Naeem, Hebatullah Laban, Sven Zukunft, Rushendhiran Kesavan, Rüdiger Popp
Publikováno v:
Proc Natl Acad Sci U S A
Arachidonic acid epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increased tumor growth and metastasis, largely on the basis of overexpression studies and the application of exogenous epoxides. Here we studied tumor growth and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca951f924d35e9a5b6fc02782fbe8699
https://publica.fraunhofer.de/handle/publica/267043
https://publica.fraunhofer.de/handle/publica/267043