BACE-1 inhibition by a series of ψ[CH 2NH] reduced amide isosteres

Autor: Coburn, Craig A., Stachel, Shawn J., Jones, Kristen G., Steele, Thomas G., Rush, Diane M., DiMuzio, Jillian, Pietrak, Beth L., Lai, Ming-Tain, Huang, Qian, Lineberger, Janet, Jin, Lixia, Munshi, Sanjeev, Katharine Holloway, M., Espeseth, Amy, Simon, Adam, Hazuda, Daria, Graham, Samuel L., Vacca, Joseph P.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 2006 16(14):3635-3638

Synthesis of amicetose by three enantioselective methods

Autor: Noecker, Lincoln A ^a, Martino, Joseph A ^a, Foley, Paul J ^a, Rush, Diane M ^a, Giuliano, Robert M ^{a, *}, Villani, Frank J, Jr. ^b

Publikováno v: In Tetrahedron: Asymmetry 1998 9(2):203-212

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

Autor: Coburn CA; Department of Medicinal Chemistry, Merck Research Laoratories, West Point, PA 19486-0004, USA. craig_coburn@merck.com, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2004 Dec 02; Vol. 47 (25), pp. 6117-9.