Discovery, Synthesis, and In Vitro Characterization of 2,3 Derivatives of 4,5,6,7-Tetrahydro-Benzothiophene as Potent Modulators of Retinoic Acid Receptor-Related Orphan Receptor γt.

Autor: Fouda A; Department of Experimental Surgery, McGill University, Montréal, Québec H3G 1A4, Canada.; Research Institute of the McGill University Health Centre, Montréal, Québec H3H 2R9, Canada., Negi S; Research Institute of the McGill University Health Centre, Montréal, Québec H3H 2R9, Canada., Zaremba O; Enamine Ltd, Kyïv 02660, Ukraine., Gaidar RS; Chemspace LLC, Kyïv 02094, Ukraine., Moroz YS; Chemspace LLC, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyïv, Kyïv 01601, Ukraine., Rusanov E; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyïv 02094, Ukraine.; Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich CH-8093, Switzerland., Paraskevas S; Department of Experimental Surgery, McGill University, Montréal, Québec H3G 1A4, Canada.; Research Institute of the McGill University Health Centre, Montréal, Québec H3H 2R9, Canada.; Department of Surgery, McGill University, Montréal, Québec H3G 1A4, Canada.; McGill University Health Centre, Montréal, Québec H4A 3J1, Canada., Tchervenkov J; Department of Experimental Surgery, McGill University, Montréal, Québec H3G 1A4, Canada.; Research Institute of the McGill University Health Centre, Montréal, Québec H3H 2R9, Canada.; Department of Surgery, McGill University, Montréal, Québec H3G 1A4, Canada.; McGill University Health Centre, Montréal, Québec H4A 3J1, Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jun 08; Vol. 66 (11), pp. 7355-7373. Date of Electronic Publication: 2023 May 12.

Expanding the Chemical Space of 1,2-Difunctionalized Cyclobutanes.

Autor: Chernykh AV; Enamine Ltd. (www.enamine.net), Chervonotkatska Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Kudryk OV; Enamine Ltd. (www.enamine.net), Chervonotkatska Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Olifir OS; Enamine Ltd. (www.enamine.net), Chervonotkatska Street 78, Kyïv 02094, Ukraine.; V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry at National Academy of Sciences of Ukraine, Akademik Kukhar Street 1, Kyïv 02094, Ukraine., Dobrydnev AV; Enamine Ltd. (www.enamine.net), Chervonotkatska Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine., Rusanov E; Institute of Organic Chemistry at National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyïv 02094, Ukraine.; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zürich 8093, Switzerland., Moskvina VS; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine.; V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry at National Academy of Sciences of Ukraine, Akademik Kukhar Street 1, Kyïv 02094, Ukraine., Volochnyuk DM; Enamine Ltd. (www.enamine.net), Chervonotkatska Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine.; Institute of Organic Chemistry at National Academy of Sciences of Ukraine, Akademik Kukhar Street 5, Kyïv 02094, Ukraine., Grygorenko OO; Enamine Ltd. (www.enamine.net), Chervonotkatska Street 78, Kyïv 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyïv 01601, Ukraine.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2023 Mar 03; Vol. 88 (5), pp. 3109-3131. Date of Electronic Publication: 2023 Feb 13.

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A Ring Opening-Annulation Reaction of Anthra[1,2- d ][1,2,3]triazine-4,7,12(3 H )-trione in the Presence of Pyridines as an Efficient Approach to the Construction of Naphtho[2,3- H ]pyrido(quinolino)[2,1- b ]quinazoline System.

Autor: Zvarych V; Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, 79013 Lviv, Ukraine., Stasevych M; Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, 79013 Lviv, Ukraine., Rusanov E; Department of Chemistry of Functional Heterocyclic Systems, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 02660 Kyiv, Ukraine., Vovk M; Department of Chemistry of Functional Heterocyclic Systems, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 02660 Kyiv, Ukraine.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Sep 12; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 12.

Synthesis and alkylation of 1-alkyl(aryl)-4-cyano-3-dicyanomethylene-substituted carbo[ c]fused pyridines. Molecular and crystal structure of 2-(4-cyano-1-methyl-5,6,7,8-tetrahydroisoquinolin-3-yl)-2-(2-oxo-2-phenylethyl)malononitrile and 10-amino-8-phenyl-5-(2-chlorophenyl)-1,2,3,4-tetrahydro-7 H-pyrido[2′,3′:3,4]cyclopenta[1,2- c]isoquinoline-7,7,9-tricarbonitrile

Autor: Dyachenko, I.¹ ivladya87@e-mail.ua, Rusanov, E.², Gutov, A.², Vovk, M.² mvovk@i.com.ua

Publikováno v: Russian Journal of General Chemistry. Jul2013, Vol. 83 Issue 7, p1383-1393. 11p. 4 Diagrams, 4 Charts.