Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ruqian Lyu"'
Autor:
Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman, Pilar Blancafort
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plastic
Externí odkaz:
https://doaj.org/article/57f17a1387644e289dd4a0fa2cd044ff
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an indivi
Externí odkaz:
https://doaj.org/article/6d9f727f079f4487a2922fa34a5e57c8
Autor:
Anojian Koneshamoorthy, Dilan Seniveratne-Epa, Genevieve Calder, Matthew Sawyer, Thomas W. H. Kay, Stephen Farrell, Thomas Loudovaris, Lina Mariana, Davis McCarthy, Ruqian Lyu, Xin Liu, Peter Thorn, Jason Tong, Lit Kim Chin, Margaret Zacharin, Alison Trainer, Shelby Taylor, Richard J. MacIsaac, Nirupa Sachithanandan, Helen E. Thomas, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
We present a case of an obese 22-year-old man with activating GCK variant who had neonatal hypoglycemia, re-emerging with hypoglycemia later in life. We investigated him for asymptomatic hypoglycemia with a family history of hypoglycemia. Genetic tes
Externí odkaz:
https://doaj.org/article/4a69cf2b5644469b9f635ac9052ea7b7
Autor:
Momeneh Foroutan, Dharmesh D. Bhuva, Ruqian Lyu, Kristy Horan, Joseph Cursons, Melissa J. Davis
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Gene set scoring provides a useful approach for quantifying concordance between sample transcriptomes and selected molecular signatures. Most methods use information from all samples to score an individual sample, leading to unsta
Externí odkaz:
https://doaj.org/article/cc96eb218221438b85ea928bfcdebce2
Publikováno v:
F1000Research, Vol 8 (2019)
Advances in RNA sequencing (RNA-seq) technologies that measure the transcriptome of biological samples have revolutionised our ability to understand transcriptional regulatory programs that underpin diseases such as cancer. We recently published sing
Externí odkaz:
https://doaj.org/article/ba874ed4396a4137b5b82a35215ae930
Autor:
Ramin Shayan, Marc G. Achen, Dovile Anderson, Davis J. McCarthy, Cameron J. Nowell, Tara Karnezis, Darren J. Creek, Steven Morgan, Nadeeka Bandara, Ahmad M. Mehdi, Ruqian Lyu, Musarat Ishaq
Publikováno v:
International Journal of Obesity. 46:502-514
Objectives Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is often mistaken for obesity and causes significant impairment to mobility and quality-of-life. To identify molecular mechanisms underpinning lipedema, we employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7afc0027a8a1fc9d353e836320114e
https://doi.org/10.1038/s41366-021-01002-1
https://doi.org/10.1038/s41366-021-01002-1
Autor:
Ruqian Lyu
This repository contains: The preprocessing workflows (in Snakemake files) for analysing the single-cell DNA sequencing of sperm cells and bulk DNA sequencing from Fancm mice for crossover detection The HTML analysis reports The R scripts used for ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117133969c7df074b61ca25cf5d165d0
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Genome Biology
Genome Biology
Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an individual’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c890cb48101f28dcafe1a446ab174249
https://doaj.org/article/6d9f727f079f4487a2922fa34a5e57c8
https://doaj.org/article/6d9f727f079f4487a2922fa34a5e57c8
Autor:
Nadia Rajab, Linden J. Gearing, Ruqian Lyu, Yair D.J. Prawer, Paul W. Angel, Sean M. Grimmond, Andrew L. Laslett, Davis J. McCarthy, Christine A. Wells
Macrophages coordinate the initial host inflammatory response to tissue infection, as well as mediating the reparative phase, by producing growth factors that promote tissue repair. One model of this functional dichotomy is that peripherally recruite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ead986bc9d8d6ed253b1e2bbf991e6
https://doi.org/10.1101/2022.05.12.491598
https://doi.org/10.1101/2022.05.12.491598
Autor:
Davis J. McCarthy, Oliver Stegle, Sarah A. Teichmann, Raghd Rostom, Daniel J. Gaffney, Yuanhua Huang, Ruqian Lyu, Daniel J Kunz, Petr Danecek, Tzachi Hagai, Wenyi Wang, Benjamin D. Simons, Marc Jan Bonder
Publikováno v:
Nature Methods. 17:414-421
Bulk and single-cell DNA sequencing has enabled reconstructing clonal substructures of somatic tissues from frequency and cooccurrence patterns of somatic variants. However, approaches to characterize phenotypic variations between clones are not esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f3652ebb7a3fb58fd598dcfc673680
https://doi.org/10.1038/s41592-020-0766-3
https://doi.org/10.1038/s41592-020-0766-3