Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rupesh Khunt"'
Publikováno v:
RSC Advances. 6:75202-75206
A diversity-oriented approach for the synthesis of 2-aminoimidazoles is presented. The method involves the cyclization of secondary propargylamines using iodine allowing the generation of diversely-substituted 2-aminoimidazoles. The iodo group genera
Autor:
Rupesh Khunt, Ulrich Jordis, Kurt Mereiter, Alex Odermatt, Igor Beseda, Christian Stanetty, Laszlo Czollner, Rawindra Gaware, Maria Carmen Del Ruiz-Ruiz, Dirk Classen-Houben, Hassan Amer, Paul Kosma, Thierry Da Cunha, Priti Shah
Publikováno v:
Bioorganic & medicinal chemistry
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X
Autor:
Denise V. Kratschmar, Dirk Classen-Houben, Rupesh Khunt, Christian Stanetty, Ulrich Jordis, Rawindra Gaware, Paul Kosma, Thierry Da Cunha, Laszlo Czollner, Alex Odermatt
Publikováno v:
Bioorganic & medicinal chemistry
Glycyrrhetinic acid, the metabolite of the natural product glycyrrhizin, is a well known nonselective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2. Whereas inhibition of 11β-HSD1 is currently under consideration for tr