Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rupert Vessey"'
Autor:
Ke Hao, Yohan Bossé, David C. Nickle, Peter D. Paré, Dirkje S. Postma, Michel Laviolette, Andrew Sandford, Tillie L. Hackett, Denise Daley, James C. Hogg, W. Mark Elliott, Christian Couture, Maxime Lamontagne, Corry-Anke Brandsma, Maarten van den Berge, Gerard Koppelman, Alise S. Reicin, Donald W. Nicholson, Vladislav Malkov, Jonathan M. Derry, Christine Suver, Jeffrey A. Tsou, Amit Kulkarni, Chunsheng Zhang, Rupert Vessey, Greg J. Opiteck, Sean P. Curtis, Wim Timens, Don D. Sin
Publikováno v:
PLoS Genetics, Vol 8, Iss 12 (2012)
Externí odkaz:
https://doaj.org/article/1089411155cd4ffca18d2a904a27d910
Autor:
Ke Hao, Yohan Bossé, David C Nickle, Peter D Paré, Dirkje S Postma, Michel Laviolette, Andrew Sandford, Tillie L Hackett, Denise Daley, James C Hogg, W Mark Elliott, Christian Couture, Maxime Lamontagne, Corry-Anke Brandsma, Maarten van den Berge, Gerard Koppelman, Alise S Reicin, Donald W Nicholson, Vladislav Malkov, Jonathan M Derry, Christine Suver, Jeffrey A Tsou, Amit Kulkarni, Chunsheng Zhang, Rupert Vessey, Greg J Opiteck, Sean P Curtis, Wim Timens, Don D Sin
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003029 (2012)
Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown. The objectives of this study were to discover genetic var
Externí odkaz:
https://doaj.org/article/6259f2c8ff324226a4a1dc7021fe8b98
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 3 (2009)
Background: Several studies suggest that inhaled and oral corticosteroids repress systemic inflammation in chronic obstructive pulmonary disease (COPD). However, the cytokines that may respond to these medications are unclear. Method: We used data fr
Externí odkaz:
https://doaj.org/article/26896792bc494ebe8c19a3cca2f75255
Autor:
Courtney G. Havens, Correa Matthew D, Rama K. Narla, Frans Baculi, Kercher Timothy S, Thomas O. Daniel, Roy L. Harris, Brian E. Cathers, Matt Alexander, Mehran F. Moghaddam, Grant Virginia Heather Sharron, Veronique Plantevin, James Carmichael, Katalin Ebinger, Antonia Lopez-Girona, Gody Khambatta, Derek Mendy, Lawrence G Hamann, Joshua Hansen, Katerina Leftheris, Brandon Wade Whitefield, Joseph Piccotti, Nagy Mark A, Rupert Vessey, Yang Tang, Laurie LeBrun, Jim Leisten, Dehua Huang
Publikováno v:
Journal of Medicinal Chemistry. 63:6648-6676
Many patients with multiple myeloma (MM) initially respond to treatment with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide) and proteasome inhibitors. However, some patients lack an initial response to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7c02cb54b83623d7f5d29645738bcd
https://doi.org/10.1021/acs.jmedchem.9b01928
https://doi.org/10.1021/acs.jmedchem.9b01928
Autor:
Mariko Riley, Katie Stamp, Xinde Zheng, Yan Ren, Kate Blease, Chin-Chun Lu, Julia Hui, Lawrence G Hamann, Philip P Chamberlain, Gang Lu, Polat Abdubek, Mary E Matyskiela, Gondi Kumar, Maria Wang, Wei Fang, Aaron Carpenter, Thomas Clayton, Clifton Drew, Suzana Couto, Chung-Wein Lee, Mark Rolfe, Rupert Vessey, James Hartke
Publikováno v:
Nature Chemical Biology. 14:981-987
Targeted protein degradation via small-molecule modulation of cereblon offers vast potential for the development of new therapeutics. Cereblon-binding therapeutics carry the safety risks of thalidomide, which caused an epidemic of severe birth defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f5299ace6c6c8aa0af7dbee0692fbc
https://doi.org/10.1038/s41589-018-0129-x
https://doi.org/10.1038/s41589-018-0129-x
Autor:
Jeffrey L. Silber, Myron J. Levin, Gary O. Zerbe, Kenny H. Chan, Anthony R. Hayward, Rob Roy MacGregor, Anne A. Gershon, Ivan S. F. Chan, Adriana Weinberg, Rupert Vessey, Ann A. Lazar
Publikováno v:
The Journal of Infectious Diseases. 201:1024-1030
Varicella-zoster virus (VZV)–specific cell-mediated immunity responses are essential for recovery from primary (varicella) or reactivation (herpes zoster) infection with VZV [1-4]. Patients who lack adequate VZV-specific cell-mediated immunity ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6341a4f94ebee019345365b51024e55
https://doi.org/10.1086/651199
https://doi.org/10.1086/651199
Autor:
Dave Singh, S Rupert Vessey, Stephen J. Langley, Isidore Faiferman, Zoe Borrill, C. M. Houghton, Ruth Tal-Singer
Publikováno v:
British Journal of Clinical Pharmacology. 65:244-252
What is already known about this subject • Forced expiratory voume in 1 s (FEV1) is the standard measurement used to measure drug effects in chronic obstructive pulmonary disease (COPD) clinical trials. • Having previously shown that specific air
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906cddfb8a345303d953594a48af7961
https://doi.org/10.1111/j.1365-2125.2007.03013.x
https://doi.org/10.1111/j.1365-2125.2007.03013.x
Autor:
Henry M. Sarau, Michael Salmon, Trevor T. Hansel, Ruth Tal-Singer, Rupert Vessey, Rachel C. Tennant, Donald C. Carpenter, Grant C. Nicholson, Peter J. Barnes, Onn Min Kon
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 20:52-59
Rationale Smokers who develop chronic obstructive pulmonary disease (COPD) have amplified inflammation within their lungs, involving selective tissue accumulation of neutrophils, macrophages and CD8+ T cells. CD11b (Mac-1, α M β 2 -integrin) is bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9a167f761e5bcefab2cecb73f1620b
https://doi.org/10.1016/j.pupt.2005.11.009
https://doi.org/10.1016/j.pupt.2005.11.009
Autor:
M. Goldman, S. Lasenby, Rupert Vessey, Dave Singh, A. Henderson, D. Wessels, Ruth Tal-Singer, Nigel Dallow, I. Faiferman, A. Goosen
Publikováno v:
British Journal of Clinical Pharmacology. 61:398-404
Aims Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a doubl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b05f52e2ffbe57d26b386b27a126d2a
https://doi.org/10.1111/j.1365-2125.2006.02594.x
https://doi.org/10.1111/j.1365-2125.2006.02594.x
Autor:
Anthony Gibson, Kai Richter, Rudolf A. Jörres, Kathy J. Simpson, Frank Kanniess, Ruth Tal-Singer, Olaf Holz, Rupert Vessey, Stanislawa Janicki, Helgo Magnussen
Publikováno v:
The Journal of Clinical Pharmacology. 45:498-503
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, double-dummy, double-blind, placebo-controlled 3-period crossover design alternatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695be535205d27238228f28315f03404
https://doi.org/10.1177/0091270004273527
https://doi.org/10.1177/0091270004273527