Výsledky vyhledávání - "Rupert Timpl"

A Comparative Analysis of the Fibulin Protein Family

Autor: Dessislava Markova, Günter Kostka, Mon-Li Chu, Rupert Timpl, Naoyuki Kobayashi, Franz-Georg Hanisch, Hans Peter Bächinger, Douglas R. Keene, Jörg H.O. Garbe, Takako Sasaki, Takeshi Tsuda

Publikováno v: Journal of Biological Chemistry. 282:11805-11816

Fibulins are a family of five extracellular matrix proteins characterized by tandem arrays of epidermal growth factor-like domains and a C-terminal fibulin-type module. They are widely distributed and often associated with vasculature and elastic tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9b66a343ddd78ab5dc87e2d402a4b77
https://doi.org/10.1074/jbc.m611029200

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Chondroitin Sulfate Perlecan Enhances Collagen Fibril Formation

Autor: Anders Aspberg, Anna E. Johnson, Takako Sasaki, Reinhard Fässler, Attila Aszódi, Rupert Timpl, Alexander J. Kvist, Matthias Mörgelin, Karin Lindblom, Erika Gustafsson, Eva Bengtsson

Publikováno v: Journal of Biological Chemistry. 281:33127-33139

Inactivation of the perlecan gene leads to perinatal lethal chondrodysplasia. The similarity to the phenotypes of the Col2A1 knock-out and the disproportionate micromelia mutation suggests perlecan involvement in cartilage collagen matrix assembly. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8019920c630751e4edc22f4e171bc63
https://doi.org/10.1074/jbc.m607892200

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WARP Is a Novel Multimeric Component of the Chondrocyte Pericellular Matrix That Interacts with Perlecan

Autor: Uwe Hansen, Peter Bruckner, Rupert Timpl, Rick T. Owens, Takako Sasaki, Richard Wilson, Jamie Fitzgerald, John F. Bateman, Justin M. Allen

Publikováno v: Journal of Biological Chemistry. 281:7341-7349

WARP is a novel member of the von Willebrand factor A domain superfamily of extracellular matrix proteins that is expressed by chondrocytes. WARP is restricted to the presumptive articular cartilage zone prior to joint cavitation and to the articular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1714627503b26a9814ed39769df33eac
https://doi.org/10.1074/jbc.m513746200

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Structural basis for Gas6–Axl signalling

Autor: Rupert Timpl, Naomi J Clout, Erhard Hohenester, Axel Ullrich, Walter Göhring, Pjotr Knyazev, Yuri Cheburkin, Takako Sasaki

Publikováno v: The EMBO Journal. 25:80-87

Receptor tyrosine kinases of the Axl family are activated by the vitamin K-dependent protein Gas6. Axl signalling plays important roles in cancer, spermatogenesis, immunity, and platelet function. The crystal structure at 3.3 A resolution of a minima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f43813ff4208049e08b0b92085f586
https://doi.org/10.1038/sj.emboj.7600912

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Disruption of perlecan binding and matrix assembly by post-translational or genetic disruption of dystroglycan function

Autor: Takako Sasaki, Daniel E. Michele, Rita Barresi, Jakob S. Satz, Hajime Kusano, Michael D. Henry, Motoi Kanagawa, Rupert Timpl, Kevin P. Campbell

Publikováno v: FEBS Letters. 579:4792-4796

Dystroglycan is a cell-surface matrix receptor that requires LARGE-dependent glycosylation for laminin binding. Although the interaction of dystroglycan with laminin has been well characterized, less is known about the role of dystroglycan glycosylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358074627d497e903942c6eb61df2318
https://doi.org/10.1016/j.febslet.2005.07.059

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Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis

Autor: Takako Sasaki, Satoshi Amano, Kuniko Kadoya, K. Matsuzaki, Norio Kumagai, Günter Kostka, Rupert Timpl, Toshio Nishiyama, L. Y. Sakai

Publikováno v: British Journal of Dermatology. 153:607-612

Summary Background Fibulin-5 was recently found as a secreted extracellular matrix protein that functions as a scaffold for elastic fibres. However, the distribution of fibulin-5 in human skin and its changes during the ageing process are not known.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed7c13aa7b7a38ba7c0440ab00f8a344
https://doi.org/10.1111/j.1365-2133.2005.06716.x

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Laminin γ3 Chain Binds to Nidogen and Is Located in Murine Basement Membranes

Autor: Nicolai Miosge, Rupert Timpl, Eddie Kohfeldt, Takako Sasaki, Nikolaus Gersdorff

Publikováno v: Journal of Biological Chemistry. 280:22146-22153

Recently a novel laminin gamma3 chain was identified in mouse and human and shown to have the same modular structure as the laminin gamma1 chain. We expressed two fragments of the gamma3 chain in mammalian cells recombinantly. The first, domain VI/V,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb380d4ed17a846f16a38480e0e181f
https://doi.org/10.1074/jbc.m501875200

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