Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Rupert G Fray"'
Autor:
Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological m
Externí odkaz:
https://doaj.org/article/8fdaac6eb0dd41889920c42b595de135
Autor:
Michele Pallucchini, Martina Franchini, Enas M. El-Ballat, Nathalie Narraidoo, Benjamin Pointer-Gleadhill, Matthew J. Palframan, Christopher J. Hayes, David Dent, Edward C. Cocking, Michele Perazzolli, Rupert G. Fray, Phil J. Hill
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Gluconacetobacter diazotrophicus is a nitrogen fixing bacterium able to colonise a wide range of host plants and is marketed as a biofertiliser due to its ability to promote plant growth. This study aims to investigate how biological nitrogen fixatio
Externí odkaz:
https://doaj.org/article/e28b041e48c94283b0adf4dcb38d3645
Publikováno v:
Frontiers in RNA Research, Vol 2 (2024)
Eukaryotic mRNA cap structures directly influence mRNA stability, translation, and immune recognition. While the significance of the mRNA cap itself has been well-established, recent research has revealed the intricate modifications to the nucleotide
Externí odkaz:
https://doaj.org/article/ade8fe497913417386270257db6d1130
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132090 (2015)
Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO's (Fat Mass Obesity) N6-methyl-adenosine (m6A) deaminase activity, thus suggesting a link between obesity-
Externí odkaz:
https://doaj.org/article/e1a48ac3b7a14424bb079b4bfb01a184
Autor:
Seosamh Ó Lochlainn, Helen C Bowen, Rupert G Fray, John P Hammond, Graham J King, Philip J White, Neil S Graham, Martin R Broadley
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17814 (2011)
Zinc (Zn) and cadmium (Cd) hyperaccumulation may have evolved twice in the Brassicaceae, in Arabidopsis halleri and in the Noccaea genus. Tandem gene duplication and deregulated expression of the Zn transporter, HMA4, has previously been linked to Zn
Externí odkaz:
https://doaj.org/article/a93569f26d42404c81e6e4a9a48ff360
Autor:
Mi Zhang, Zsuzsanna Bodi, Katarzyna Mackinnon, Silin Zhong, Nathan Archer, Nigel P. Mongan, Gordon G. Simpson, Rupert G. Fray
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The components of m6A writer and their interactions are still far from fully understood. Here, the authors identify two HAKAI-interacting zinc finger proteins, HIZ1 and HIZ2, as components of the Arabidopsis m6A writer complex, and show that hiz2 mut
Externí odkaz:
https://doaj.org/article/17690804119f4a7a9e603da1238ac7af
Autor:
Jennifer Lothion-Roy, Daisy B. Haigh, Anna E. Harris, Veronika M. Metzler, Mansour Alsaleem, Michael S. Toss, Yousif Kariri, Atara Ntekim, Brian D. Robinson, Francesca Khani, Lorraine J. Gudas, Cinzia Allegrucci, Victoria H. James, Srinivasan Madhusudan, Melissa Mather, Richard D. Emes, Nathan Archer, Rupert G. Fray, Emad Rakha, Jennie N. Jeyapalan, Catrin S. Rutland, Nigel P. Mongan, Corinne L. Woodcock
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are
Externí odkaz:
https://doaj.org/article/ee16cd5a10274e0e9f3c44999cecb5f8
Autor:
Francis Baron, Mi Zhang, Nathan Archer, Eleanor Bellows, Helen M. Knight, Simon Welham, Catrin S. Rutland, Nigel P. Mongan, Christopher J. Hayes, Rupert G. Fray, Zsuzsa Bodi
Publikováno v:
RNA. 29:777-789
N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using m6A-specific methylated RNA immunoprecipitation with next-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bd06f44c95b9cb2437fb91a4337e2e
https://doi.org/10.1261/rna.079615.123
https://doi.org/10.1261/rna.079615.123
Autor:
Matthias Soller, Daniel Hebenstreit, Irmgard U. Haussmann, Zsuzsanna Bodi, Rupert G. Fray, Yin-Hu Wu, Nathan Archer, Scott Waddell, Mohanakarthik Ponnadai Nallasivan
Cap-adjacent nucleotides of animal, protist and viral mRNAs can be O-methylated at the 2‘ position of the ribose (cOMe). The functions of cOMe in animals, however, remain largely unknown. Here we show that the two cap methyltransferases (CMTr1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f0bcfcc3b4695f894f02c182da42eb
Autor:
Xiang Yu, Mateusz Bajczyk, Lukasz Szewc, Zofia Szweykowska-Kulinska, Rupert G. Fray, Dawid Bielewicz, Natalia Grzelak, Tomasz Gulanicz, Stephen J. Anderson, Zsuzsanna Bodi, Jakub Dolata, Dariusz Jan Smoliński, Artur Jarmolowski, Susheel Sagar Bhat, Brian D. Gregory
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Recently N6-methyladenosine (m6A) methylation has emerged as a biological process with significant impact on cellular functions. However, almost all the research regarding m6A methylation has been based on mRNAs. In our research, we focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c66b025f6cfe2656699b618ba82b476
https://doi.org/10.1073/pnas.2003733117
https://doi.org/10.1073/pnas.2003733117