Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Rupal S Bhatt"'
Autor:
Liang Zhang, Manoj Bhasin, Rachel Schor-Bardach, Xiaoen Wang, Michael P Collins, David Panka, Prabhakar Putheti, Sabina Signoretti, David C Alsop, Towia Libermann, Michael B Atkins, James W Mier, S Nahum Goldberg, Rupal S Bhatt
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19144 (2011)
Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic changes in resistant tumor cells.Mic
Externí odkaz:
https://doaj.org/article/0f88b96b13b7498bbbbc46eea851c48d
Autor:
Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Kathleen M. Mahoney
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background The immune checkpoint HERV-H LTR-associating 2 (HHLA2) is expressed in kidney cancer and various other tumor types. Therapeutics targeting HHLA2 or its inhibitory receptor KIR3DL3 are being developed for solid tumors, including re
Externí odkaz:
https://doaj.org/article/85e734b4145c41299dfe482e37286e82
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 4 (2021)
Resistance to tyrosine kinase inhibitors of the vascular endothelial growth factor receptor inevitably develops in most patients with metastatic kidney cancer. Our recent findings demonstrate that addition of angiotensin-(1-7) peptide can be a potent
Externí odkaz:
https://doaj.org/article/1390a2efbfe946d694be9e43af950a70
Autor:
Junhui Hu, Shiruyeh Schokrpur, Maani Archang, Kip Hermann, Allison C. Sharrow, Prateek Khanna, Jesse Novak, Sabina Signoretti, Rupal S. Bhatt, Beatrice S. Knudsen, Hua Xu, Lily Wu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 203-210 (2018)
The CRISPR-based technology has revolutionized genome editing in recent years. This technique allows for gene knockout and evaluation of function in cell lines in a manner that is far easier and more accessible than anything previously available. Unf
Externí odkaz:
https://doaj.org/article/dc3d596a55cd4d0499009cc95592f618
Autor:
Gordon J. Freeman, Sabina Signoretti, Antonio R. Arulanandam, David F. McDermott, Jie Zhu, Jo Soden, Ping Hua, Baogong Zhu, Maura Sticco-Ivins, Jean-Christophe Pignon, Paul J. Catalano, Opeyemi A. Jegede, Chun-Hau Chen, Samuel S. Freeman, Alyssa N. Klee, Kathleen M. Mahoney, Julie C. Konge, Abdulla Berjis, Rupal S. Bhatt
Blockade of the PD1 pathway is a broadly effective cancer therapy, but additional immune-inhibitory pathways contribute to tumor immune evasion. HERV–H LTR-associating 2 (HHLA2; also known as B7H5 and B7H7) is a member of the B7 family of immunoreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332b94b9c7b92f3f2b93b94a42d4aa9f
https://doi.org/10.1158/2326-6066.c.6550380.v1
https://doi.org/10.1158/2326-6066.c.6550380.v1
Autor:
Gordon J. Freeman, Sabina Signoretti, Antonio R. Arulanandam, David F. McDermott, Jie Zhu, Jo Soden, Ping Hua, Baogong Zhu, Maura Sticco-Ivins, Jean-Christophe Pignon, Paul J. Catalano, Opeyemi A. Jegede, Chun-Hau Chen, Samuel S. Freeman, Alyssa N. Klee, Kathleen M. Mahoney, Julie C. Konge, Abdulla Berjis, Rupal S. Bhatt
Supplementary Figures 1-7 and Supplementary Tables 1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26775238f169d7ce6bf99bf38eb87c67
https://doi.org/10.1158/2326-6066.22543728
https://doi.org/10.1158/2326-6066.22543728
Autor:
Rupal S. Bhatt, Laura E. Benjamin, David C. Alsop, Damien Gerald, Sudhakar Chintharlapalli, Mark T. Uhlik, Jason Manro, Philip Hipskind, Takako Wilson, Julie Stewart, Glenn Evans, Diane Bodenmiller, Rowena Almonte-Baldonado, Beverly L. Falcon, Xiaoen Wang, Anthony S. Fischl
Inhibition of VEGFR signaling is an effective treatment for renal cell carcinoma, but resistance continues to be a major problem. Recently, the sphingosine phosphate (S1P) signaling pathway has been implicated in tumor growth, angiogenesis, and resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07698e2d3dbef68e4960d1e590a94e57
https://doi.org/10.1158/1535-7163.c.6537817.v1
https://doi.org/10.1158/1535-7163.c.6537817.v1
Autor:
Sabina Signoretti, Gordon J. Freeman, David F. McDermott, Toni K. Choueiri, F. Stephen Hodi, Michael B. Atkins, Rupal S. Bhatt, Ingrid Carvo, Jiaxi Song, André P. Fay, Elizabeth M. Genega, Su-Chun Cheng, Mamta Gupta, Laurence Albiges, Marcella Callea
PD-L1 positivity in relation to tumor grade within individual lesions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7bb7ccbf0fb065ffe8ca80b1abe40c
https://doi.org/10.1158/2326-6066.22538789
https://doi.org/10.1158/2326-6066.22538789
Autor:
Sabina Signoretti, Gordon J. Freeman, David F. McDermott, Toni K. Choueiri, F. Stephen Hodi, Michael B. Atkins, Rupal S. Bhatt, Ingrid Carvo, Jiaxi Song, André P. Fay, Elizabeth M. Genega, Su-Chun Cheng, Mamta Gupta, Laurence Albiges, Marcella Callea
PD-L1 expression in primary clear-cell renal cell carcinoma (ccRCC) increases the likelihood of response to anti–PD-1 inhibition, but fails to identify all responders. We hypothesized that PD-L1 levels assessed in randomly selected areas of the pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96b1e39a7ea18ec3216615a1feb2717
https://doi.org/10.1158/2326-6066.c.6548894
https://doi.org/10.1158/2326-6066.c.6548894
Autor:
Rupal S. Bhatt, Laura E. Benjamin, David C. Alsop, Damien Gerald, Sudhakar Chintharlapalli, Mark T. Uhlik, Jason Manro, Philip Hipskind, Takako Wilson, Julie Stewart, Glenn Evans, Diane Bodenmiller, Rowena Almonte-Baldonado, Beverly L. Falcon, Xiaoen Wang, Anthony S. Fischl
Figure S1: Impedance barrier function assay: The effect of S1P and Ex82 was analyzed using a transendothelial electrical impedance assay. S1P treatment (10 nM) of an endothelial monolayer strongly increases electrical impedance (B) vs control (A) whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902b8ba918c7477299546439c91ade34
https://doi.org/10.1158/1535-7163.22504642.v1
https://doi.org/10.1158/1535-7163.22504642.v1