Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rupa Shetty"'
Publikováno v:
Psychiatry International, Vol 5, Iss 2, Pp 231-240 (2024)
Esotropia, which is the medial deviation of one or both eyes, is a rare withdrawal symptom that has been associated with opiate addiction. We report a case of a 36-year-old female patient who developed acute-onset esotropia and diplopia after self-ad
Externí odkaz:
https://doaj.org/article/7b51dada1428470e82af7c0859318f82
Autor:
Juan Luengo, Shuilong Tong, Yang Zhang, Rupa Shetty, Hong Lin, Min Wang, Kris Vaddi, Raul A. Leal
Publikováno v:
ACS Medicinal Chemistry Letters
Protein arginine methyltransferase 5 (PRMT5) is known to symmetrically dimethylate numerous cytosolic and nuclear proteins that are involved in a variety of cellular processes. Recent findings have revealed its potential as a cancer therapeutic targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ecbd4ef6481346db40411077a4e276
http://europepmc.org/articles/PMC6627734
http://europepmc.org/articles/PMC6627734
Autor:
Srdan Verstovsek, Yang Zhang, Ross L. Levine, Alexander Grego, William Gowen-MacDonald, Taghi Manshouri, Dimitrios Angelis, Hong Lin, Peggy Scherle, Juan Luengo, Min Wang, Kris Vaddi, Neha Bhagwat, Dave Rominger, Tom Emm, Bruce Ruggeri, Raul A. Leal, Rupa Shetty, Friederike Pastore, Divya Chugani-Mahtani
Publikováno v:
Cancer Research. 80:2915-2915
Protein arginine methyltransferase 5 (PRMT5) is the major type II PRMT that catalyzes the formation of symmetrical dimethyl arginine (SDMA) on protein substrates and plays important roles in various cellular pathways including tumorigenesis. PRMT5 ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22259afd761bc23c7d8f64650167a2b
https://doi.org/10.1158/1538-7445.am2020-2915
https://doi.org/10.1158/1538-7445.am2020-2915
Autor:
Rupa Shetty, Dietmar Flubacher, Duyan Nguyen, Andreas Schumacher, Enrique Luis Michelotti, Franziska Ruggle, Martha J. Kelly
Publikováno v:
Tetrahedron Letters. 48:113-117
A regioselective synthesis of 2,4,6-trisubstituted pyridine is described starting from 2,6-dibromo-4-nitropyridine. All three different regioisomers of the 2,4,6-triamino substituted pyridine have been synthesized in four to five steps. The method de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6333ddc77ab6791058018204bd450fb9
https://doi.org/10.1016/j.tetlet.2006.10.159
https://doi.org/10.1016/j.tetlet.2006.10.159
Autor:
Gary A. Flynn, Duyan Nguyen, Xiaomei Chai, Brandon A. Campbell, Marina Bukhtiyarova, Enrique Luis Michelotti, Eric B. Springman, Rupa Shetty, Variketta Namboodiri, Frank Hollinger, Katrina Northrop, Ted T. Fujimoto, Martha Jean Kelly, Michael Karpusas, Kristofer K. Moffett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5274-5279
Two new classes of diphenylether inhibitors of p38alpha MAP kinase are described. Both chemical classes are based on a common diphenylether core that is identified by simulated fragment annealing as one of the most favored chemotypes within a promine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86ba9e3cf8b549da419b75bf00cb5c5
https://doi.org/10.1016/j.bmcl.2005.08.038
https://doi.org/10.1016/j.bmcl.2005.08.038
Autor:
Robert M. Carlson, David S. Watt, Ivan L. Stoilov, Frederick J. Fago, J. Michael Moldowan, Rupa Shetty
Publikováno v:
The Journal of Organic Chemistry. 59:8203-8208
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa6390675305d2f9461443a68454637
https://doi.org/10.1021/jo00105a043
https://doi.org/10.1021/jo00105a043
Autor:
Michael Karpusas, Ted T. Fujimoto, Kyoung-Jin Lee, Eric B. Springman, Xiaomei Chai, Jennifer L. Ludington, Marina Bukhtiyarova, Kristofer K. Moffett, Enrique Luis Michelotti, Frank Guarnieri, Duyan Nguyen, Haridasan V M Namboodiri, Zenon Konteatis, Bruce D. Dorsey, Rupa Shetty
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(23)
Discovery of a new class of DFG-out p38α kinase inhibitors with no hinge interaction is described. A computationally assisted, virtual fragment-based drug design (vFBDD) platform was utilized to identify novel non-aromatic fragments which make produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcee79c0b677f4c6c42f27ff031c8bea
https://pubmed.ncbi.nlm.nih.gov/22014550
https://pubmed.ncbi.nlm.nih.gov/22014550
Publikováno v:
ChemInform. 42
An efficient synthesis of 1,3,5-trisubstituted benzenes via a sequential Pd-mediated carbon–sulfur, carbon–nitrogen, and carbon–carbon bond formation reactions is reported. Selective amidation and sulfonamidation reactions are accomplished via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91671e58cf13338396ebd94532940306
https://doi.org/10.1002/chin.201128145
https://doi.org/10.1002/chin.201128145
Autor:
David L. Nelson, John Mihelcic, Rhoda W. Joseph, Gary A. Flynn, Ted Tsutomu Four Valley Square Fujimoto, Young Hee Lee, Dietmar Flubacher, Andreas Schumacher, Ken Williams, Eric B. Springman, Marina Bukhtiyarova, Michael S. Saporito, Arifa Husain, Bruce D. Dorsey, Rupa Shetty, Aleksandar Stojanovic, Alexander R. Ochman, Yixin Lu, William R. Moore, Martha J. Kelly, Bin Liu, Wenchun Chao, Kristofer K. Moffett, Kyoung-Jin Lee
Publikováno v:
Journal of medicinal chemistry. 54(1)
The synthesis and optimization of a series of orally bioavailable 1-(1H-indol-4-yl)-3,5-disubstituted benzene analogues as antimitotic agents are described. A functionalized dibromobenzene intermediate was used as a key scaffold, which when modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1783eeac421d19e3fd4bfb0b853983
https://pubmed.ncbi.nlm.nih.gov/21126027
https://pubmed.ncbi.nlm.nih.gov/21126027
Autor:
Rupa Shetty, Kristofer K. Moffett
Publikováno v:
ChemInform. 38
Several 2,5-disubstituted benzyl alcohols containing a functionalized t-butyl moiety were synthesized via palladium catalyzed α-arylation of methyl isobutyrate and butyronitrile on synthetically useful scales. The resulting benzyl alcohols could the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7c44b9bb6b524ab428cab7f4e4f0662
https://doi.org/10.1002/chin.200709084
https://doi.org/10.1002/chin.200709084