Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rupa Padaki"'
Autor:
Neungseon Seo, Xiaoyan Guan, Tian Wang, Hyo S. Helen Chung, Mats Wikström, Rupa Padaki, Kevin Kalenian, Scott Kuhns, Kelli Matthies, Jill Crouse-Zeineddini, Helen Y. Wong, Michael Ng, Ian N. Foltz, Shawn Cao, Jennifer Liu
Publikováno v:
Ophthalmology and Therapy, Vol 13, Iss 5, Pp 1303-1320 (2024)
Abstract Introduction ABP 938 is being developed as a biosimilar candidate to aflibercept reference product (RP), a biologic used for certain angiogenic eye disorders. This study was designed to provide a comparative analytical assessment of the stru
Externí odkaz:
https://doaj.org/article/f2288437a8274d48b45398da06a6f337
Autor:
Shufang Liu, Sara C. Humphreys, Kevin D. Cook, Kip P. Conner, Ana R. Correia, Alex W. Jacobitz, Melissa Yang, Ronya Primack, Marcus Soto, Rupa Padaki, Mariusz Lubomirski, Richard Smith, Marissa Mock, Veena A. Thomas
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTIn this investigation, we tested the hypothesis that a physiologically based pharmacokinetic (PBPK) model incorporating measured in vitro metrics of off-target binding can largely explain the inter-antibody variability in monoclonal antibody
Externí odkaz:
https://doaj.org/article/ba5447ad553b4a998a1ea0915308c3b4
Autor:
Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang, Iain D. G. Campuzano
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBiologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient admin
Externí odkaz:
https://doaj.org/article/c7e86c82a6684b888888da7d561e8891
Autor:
Daniel W. Woodall, Thomas M. Dillon, Kevin Kalenian, Rupa Padaki, Scott Kuhns, David J. Semin, Pavel V. Bondarenko
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Antibodies facilitate targeted cell killing by engaging with immune cells such as natural killer cells through weak binding interactions with Fcγ receptors on the cell surface. Here, we evaluate the binding affinity of the receptor FcγRIIIa V158 (C
Externí odkaz:
https://doaj.org/article/3d80519d7d5a4b369155036a9e5272d1
Publikováno v:
FEBS Open Bio, Vol 11, Iss 11, Pp 2943-2949 (2021)
It has been well documented that the terminal sugars of Fc glycans can play a critical role in the safety and efficacy of therapeutic mAbs. However, many of the effects of highly heterogeneous Fc glycan structures have yet to be fully characterized.
Externí odkaz:
https://doaj.org/article/f08697e91998419f8ca34d8371196493
Autor:
Mark A. Kroenke, Troy E. Barger, Jenny Hu, Mieke Jill Miller, Kevin Kalenian, Lidong He, Hailing Hsu, Yessenia Bartley, Vincent Fung-Sing Chow, Marcia Cristina Teixeira dos Santos, Barbara A. Sullivan, Laurence E. Cheng, Jane R. Parnes, Rupa Padaki, Scott Kuhns, Daniel T. Mytych
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
AMG 966 is a bi-specific, heteroimmunoglobulin molecule that binds both tumor necrosis factor alpha (TNFα) and TNF-like ligand 1A (TL1A). In a first-in-human clinical study in healthy volunteers, AMG 966 elicited anti-drug antibodies (ADA) in 53 of
Externí odkaz:
https://doaj.org/article/bb8a16473b134591babbad71b1979d57
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:223-231
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in different pathophysiologies that include asthma, cough, itch, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b02942cd0d5d651e923158904000cb
https://doi.org/10.1124/jpet.114.215574
https://doi.org/10.1124/jpet.114.215574
Autor:
Teri L. Aldrich, Frederick W. Jacobsen, Rupa Padaki, Taruna Arora, Martin J. Allen, Jennifer C. Lavallee, Richard J. Armitage, Arvia E. Morris
Publikováno v:
The Journal of Immunology. 186:341-349
Studies for vaccine and human therapeutic Ab development in cynomolgus monkeys (cynos) are influenced by immune responses, with Ab responses playing a significant role in efficacy and immunogenicity. Understanding the nature of cyno humoral immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3324005af018809c82555929b17153ec
https://doi.org/10.4049/jimmunol.1001685
https://doi.org/10.4049/jimmunol.1001685
Autor:
Seth R. Stevens, Aaron R. Ellison, James S. Louie, Rupa Padaki, Ling Liu, Taruna Arora, Agnes Eva Hamburger, Tadahiko Kohno
Publikováno v:
Cytokine. 45:124-131
There are currently two Food and Drug Administration-approved classes of biologic agents that target tumor necrosis factor-alpha (TNF-alpha): anti-TNF monoclonal antibodies (mAbs) (adalimumab and infliximab), and soluble TNF receptors (etanercept). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ea28ccca5aebb1a49d48a053521892
https://doi.org/10.1016/j.cyto.2008.11.008
https://doi.org/10.1016/j.cyto.2008.11.008
Autor:
Scott Smallwood, Anne-Marie C Rousseau, Ling Liu, Weichun Wang, Taruna Arora, Andrea Beard, Pranhitha Reddy, William C. Fanslow, Rupa Padaki
Publikováno v:
Clinical Immunology. 131:S73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60059b97bfa00d83266638ce86241ab6
https://doi.org/10.1016/j.clim.2009.03.214
https://doi.org/10.1016/j.clim.2009.03.214