Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ruomu Jiang"'
Combining rare and common genetic variants improves population risk stratification for breast cancer
Autor:
Alexandre Bolze, Daniel Kiser, Kelly M. Schiabor Barrett, Gai Elhanan, Jamie M. Schnell Blitstein, Iva Neveux, Shaun Dabe, Harry Reed, Alexa Anderson, William J. Metcalf, Ekaterina Orlova, Ildiko Thibodeau, Natalie Telis, Ruomu Jiang, Nicole L. Washington, Matthew J. Ferber, Catherine Hajek, Elizabeth T. Cirulli, Joseph J. Grzymski
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101826- (2024)
Purpose: This study aimed to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer in the general population. Methods: We retrospectively studied 25,591 women with available electronic heal
Externí odkaz:
https://doaj.org/article/91c30b4199254457893c3ce310c06a65
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1808-1818 (2014)
Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important posttranslational modification involved in transcription, DNA damage repair, and stem cell identity. Previous studies established the activation of PA
Externí odkaz:
https://doaj.org/article/9a74eeeafbc34a3989a4ce63c759f033
Combining rare and common genetic variants improves population risk stratification for breast cancer
Autor:
Alexandre Bolze, Daniel Kiser, Kelly M. Schiabor Barrett, Gai Elhanan, Jamie M. Schnell Blitstein, Iva Neveux, Shaun Dabe, Harry Reed, Alexa Anderson, William J. Metcalf, Ekaterina Orlova, Ildiko Thibodeau, Natalie Telis, Ruomu Jiang, Nicole L. Washington, Matthew J. Ferber, Catherine Hajek, Elizabeth T. Cirulli, Joseph J. Grzymski
PurposeIn the United States, breast cancer clinical risk assessments are inconsistent and inequitable. The previous success ofBRCA1andBRCA2screening has demonstrated that genetics could be used to reduce these inequities, if they are available and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e4080e565505ee57c37a479e96f0bec
https://doi.org/10.1101/2023.05.17.23290132
https://doi.org/10.1101/2023.05.17.23290132
Autor:
Nicole L. Washington, William E. Lee, Shishi Luo, Joseph J. Grzymski, James T. Lu, Ruomu Jiang
Publikováno v:
Clinical Pharmacology and Therapeutics
Genomic‐guided pharmaceutical prescribing is increasingly recognized as an important clinical application of genetics. Accurate genotyping of pharmacogenomic (PGx) genes can be difficult, owing to their complex genetic architecture involving combin
Autor:
Kenichi Shimada, Richard Ventura, Ho-Chou Tu, Iris Ngan, Peter D. Koch, Harding H. Luan, Ruomu Jiang, Jui-Hsia Weng, Timothy J. Mitchison
Publikováno v:
Nat Metab
Colchicine has served as a traditional medicine for millennia and remains widely used to treat inflammatory and other disorders. Colchicine binds tubulin and depolymerizes microtubules, but it remains unclear how this mechanism blocks myeloid cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdce534c1920a55986f747bb5efad20
https://europepmc.org/articles/PMC8175070/
https://europepmc.org/articles/PMC8175070/
Autor:
Harding H. Luan, Peter D. Koch, Ruomu Jiang, Richard Ventura, Jui-Hsia Weng, Kenichi Shimada, Ho-Chou Tu, Iris Ngan, Timothy J. Mitchison
Publikováno v:
Nature Metabolism. 3:728-728
Autor:
Jorge S. Reis-Filho, Dilip Giri, Britta Weigelt, Luciano G. Martelotto, Pedro Blecua, Marcia Edelweiss, Rob Delsite, Russell Towers, Salvatore Piscuoglio, Charlotte K.Y. Ng, Robert W. Mutter, Daniel S. Higginson, Ruomu Jiang, Edi Brogi, Simon N. Powell, William Lee, Alexis Desrichard, Giana Bernheim, Maria Drobnjak, Tari A. King, Nadeem Riaz, Ranjit S. Bindra, Raymond S. Lim, Rita A. Sakr
Publikováno v:
The Journal of Pathology. 242:165-177
Homologous recombination (HR) DNA repair-deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence suggests that sporadic breast cancers, lacking germline BRCA1/BRCA2 mutations, may also be H
Autor:
Joseph J. Grzymski, Magnus Isaksson, Misha Rashkin, Ruomu Jiang, Andrew Dei Rossi, Francisco Tanudjaja, William J. Metcalf, Alexandre Bolze, William E. Lee, Simon R. White, Fernando L. Mendez, James T. Lu, Nicole L. Washington, Elizabeth T. Cirulli
SummaryHigh quality population allele frequencies of DNA variants can be used to discover new biology, and study rare disorders. Here, we created a public catalog of mitochondrial DNA variants based on a population of 195,983 individuals. We focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::986b4e32bdd9d01d561adc62e2581144
https://doi.org/10.1101/798264
https://doi.org/10.1101/798264
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1808-1818 (2014)
Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important post-translational modification involved in transcription, DNA damage repair, and stem cell identity. Previous studies established the activation of P
Autor:
Ruomu Jiang, Edwin L. Sibert
Publikováno v:
The Journal of Physical Chemistry A. 113:7275-7285
Recent infrared pump-probe studies on alcohol oligomers in CCl(4) solution reveal that, following OH stretch excitation, ultrafast hydrogen bond (H-bond) breaking takes place on a time scale of 1 ps. To shed light on the mechanism of the H-bond break