Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Ruoli Bai"'
Autor:
Jessica Sebastiani, Michela Puxeddu, Marianna Nalli, Ruoli Bai, Ludovica Altieri, Paola Rovella, Eugenio Gaudio, Daniela Trisciuoglio, Filippo Spriano, Patrizia Lavia, Cinzia Fionda, Domiziana Masci, Andrea Urbani, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Francesco Bertoni, Romano Silvestri, Giuseppe La Regina
We synthesized a new inhibitor of tubulin polymerization, the pyrrole (1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrrol-3-yl)(3,4,5-trimethoxy-phenyl)methanone 6 (RS6077). Compound 6 inhibited the growth of multiple cancer cell lines, with IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b627b1f33ba1c80296963a7e5f365b5c
https://hdl.handle.net/11573/1669754
https://hdl.handle.net/11573/1669754
Autor:
Wolfgang Dohle, Hannah Asiki, Wojciech Gruchot, Paul A. Foster, Havreen K. Sahota, Ruoli Bai, Kirsten E. Christensen, Ernest Hamel, Barry V. L. Potter
Publikováno v:
ChemMedChem. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::571bcbf228205df8d6588c54e79d0278
https://doi.org/10.1002/cmdc.202200639
https://doi.org/10.1002/cmdc.202200639
Autor:
Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D’Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina
Publikováno v:
Journal of medicinal chemistry. 65(23)
We synthesized new aroyl diheterocyclic pyrrole (ARDHEP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e537297ba1d657b358721ec95924b69
https://pubmed.ncbi.nlm.nih.gov/36395526
https://pubmed.ncbi.nlm.nih.gov/36395526
Autor:
Wolfgang Dohle, Hannah Asiki, Wojciech Gruchot, Paul A. Foster, Havreen K. Sahota, Ruoli Bai, Kirsten E. Christensen, Ernest Hamel, Barry V. L. Potter
2-Difluoromethoxyestratriene derivatives were designed to improve potency and in vivo stability of the drug candidate 2-methoxyestradiol (2ME2). Compound evaluation in vitro against the proliferation of MCF-7 and MDA MB-231 breast cancer cells, as in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00732c387004a27f9fe8b42e1e17696
https://doi.org/10.1002/cmdc.202200408
https://doi.org/10.1002/cmdc.202200408
Autor:
Adilson Beatriz, Murilo K. A. Yonekawa, Camilla I. Nantes, Maria de Fatima Cepa Matos, Ruoli Bai, Ernest Hamel, Dênis Pires de Lima, Rodrigo Juliano Oliveira, Edson dos Anjos dos Santos, Renata Trentin Perdomo, James C. Burnett, Ingrid D. Pereira, Danielle Bogo
Publikováno v:
ChemMedChem. 15:449-458
Organosulfur compounds show cytotoxic potential towards many tumor cell lines. Disulfides and thiosulfonates act through apoptotic processes, inducing proteins associated with apoptosis, endoplasmic reticulum stress, and the unfolded protein response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0f1082b9dca8b00da011f886d5e5d0
https://doi.org/10.1002/cmdc.201900566
https://doi.org/10.1002/cmdc.201900566
Autor:
Jessica Sebastiani, Michela Puxeddu, Marianna Nalli, Ruoli Bai, Ludovica Altieri, Paola Rovella, Eugenio Gaudio, Daniela Trisciuoglio, Filippo Spriano, Patrizia Lavia, Cinzia Fionda, Ernest Hamel, Francesco Bertoni, Romano Silvestri, Giuseppe La Regina
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::424b85a9e4982c2adfc89b2dfbe9d9df
https://doi.org/10.2139/ssrn.4123438
https://doi.org/10.2139/ssrn.4123438
Autor:
Marilia, Barreca, Virginia, Spanò, Roberta, Rocca, Roberta, Bivacqua, Anne-Catherine, Abel, Annalisa, Maruca, Alessandra, Montalbano, Maria Valeria, Raimondi, Chiara, Tarantelli, Eugenio, Gaudio, Luciano, Cascione, Andrea, Rinaldi, Ruoli, Bai, Michel O, Steinmetz, Andrea E, Prota, Stefano, Alcaro, Ernest, Hamel, Francesco, Bertoni, Paola, Barraja
Publikováno v:
European Journal of Medicinal Chemistry. 243:114744
Lymphomas are among the ten most common cancers, and, although progress has been achieved in increasing survival, there is still an unmet need for more effective therapeutic approaches, including better options for patients with refractory tumors tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee5e7e60207194d363fb5803d3c5b1d
https://doi.org/10.1016/j.ejmech.2022.114744
https://doi.org/10.1016/j.ejmech.2022.114744
Publikováno v:
Archives of Biochemistry and Biophysics. 730:109412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c8642a75ef6aa8f66210e414abdddff
https://doi.org/10.1016/j.abb.2022.109412
https://doi.org/10.1016/j.abb.2022.109412
Publikováno v:
Archives of Biochemistry and Biophysics. 727:109296
A tritiated derivative of the sponge-derived natural product spongistatin 1 was prepared, and its interactions with tubulin were examined. [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a230be45f504015abc4cef3b93f9c5e3
https://doi.org/10.1016/j.abb.2022.109296
https://doi.org/10.1016/j.abb.2022.109296
Publikováno v:
Pharmacologytherapeutics. 225
Heterocyclic scaffolds are widely utilized for drug design by taking into account the molecular structure of therapeutic targets that are related to a broad spectrum of ailments, including tumors. Such compounds display various covalent and non-coval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954a68e8d6f21de1f90f4b76b077e21a
https://pubmed.ncbi.nlm.nih.gov/33895188
https://pubmed.ncbi.nlm.nih.gov/33895188