Synthetic Pseudaminic-Acid-Based Antibacterial Vaccine Confers Effective Protection against Acinetobacter baumannii Infection

Autor: Ruohan Wei, Xuemei Yang, Han Liu, Tongyao Wei, Sheng Chen, Xuechen Li

Publikováno v: ACS Central Science, Vol 7, Iss 9, Pp 1535-1542 (2021)

Externí odkaz: https://doaj.org/article/d8a033b2cbe44984b6a2b2c62e1fe603

Construction of diverse peptide structural architectures via chemoselective peptide ligation

Autor: Ruohan Wei, Yanfeng Zhang, Jianchao Xu, Xuechen Li, Carina Hey Pui Cheung, Xuhui Huang, Donald Bierer, Chi Lung Lee

Publikováno v: Chemical Science. 12:7091-7097

Herein, we report the development of a facile synthetic strategy for constructing diverse peptide structural architectures via chemoselective peptide ligation. The key advancement involved is to utilize the benzofuran moiety as the peptide salicylald

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bf2d81148bccf4cacdd88374622ae39
https://doi.org/10.1039/d1sc01174j

Revealing the function of HMGB1 N-terminal acetylation by a protein semi-synthesis approach

Autor: Tongyao Wei, Jiamei Liu, Yi Tan, Can Li, Ruohan Wei, Jinzheng Wang, Hongxiang Wu, Qingrong Li, Heng Liu, Yubo Tang, Xuechen Li

HMGB1 (high-mobility group box 1) protein is a nonhistone chromatin-associated protein that has been widely reported to be a representative damage-associated molecular pattern (DAMP) and to play a pivotal role in proinflammatory process once it is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28b6074967c477202a460e4e4e919dc6
https://doi.org/10.1101/2021.10.05.463167

A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation

Autor: Ruohan Wei, Han Liu, Xuechen Li, Arthur H Tang, Richard J. Payne

Publikováno v: Wei, R, Liu, H, Tang, A H, Payne, R J & Li, X 2019, ' A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α-And β-Glycosylation ', Organic Letters, vol. 21, no. 10, pp. 3584-3588 . https://doi.org/10.1021/acs.orglett.9b00990

A robust methodology for the stereocontrolled chemical glycosylation of pseudaminic acid has been developed to afford both α- (axial) and β- (equatorial) glycosides reliably with complete stereoselectivity, using a common glycosyl donor (7N-Cbz/5N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31f15427fa718fdc06c775c72a0d872
https://doi.org/10.1021/acs.orglett.9b00990

A Solution to Chemical Pseudaminylation via Development of a Bimodal Glycosyl Donor to Enable Highly Stereocontrolled α- and β-Glycosylation

Autor: Xuechen Li, Richard Payne, Arthur Tang, Han Liu, Ruohan Wei

Bacterial pseudaminic acids (Pse) are present on the surface of many pathogenic bacteria. Herein, we report a robust methodology for the stereocontrolled chemical glycosylation of pseudaminic acid to afford both α- (axial) and β- (equatorial) glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::598bd4b1e621c61cc24ac21e6375d53d
https://doi.org/10.26434/chemrxiv.7767194