Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ruocong Zhao"'
Autor:
Jiang Lv, Le Qin, Ruocong Zhao, Di Wu, Zhiping Wu, Diwei Zheng, Siyu Li, Mintao Luo, Qiting Wu, Youguo Long, Zhaoyang Tang, Yan-Lai Tang, Xuequn Luo, Yao Yao, Li-Hua Yang, Peng Li
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 46-58 (2023)
Tumor cells and the immunosuppressive tumor microenvironment suppress the antitumor activity of T cells through immune checkpoints, including the PD-L1/PD-1 axis. Cytokine-inducible SH2-containing protein (CISH), a member of the suppressor of cytokin
Externí odkaz:
https://doaj.org/article/1adeb91ca0b54373b88030ea4ef4a683
Autor:
Le Qin, Yuanbin Cui, Tingjie Yuan, Dongmei Chen, Ruocong Zhao, Shanglin Li, Zhiwu Jiang, Qiting Wu, Youguo Long, Suna Wang, Zhaoyang Tang, Huixia Pan, Xiaoping Li, Wei Wei, Jie Yang, Xuequn Luo, Zhenfeng Zhang, Qiannan Tang, Pentao Liu, Robert Weinkove, Yao Yao, Dajiang Qin, Jean Paul Thiery, Peng Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Co-expression of PD-L1-specific chimeric switch receptors (CSRs) improves the antitumor effects of chimeric antigen receptor (CAR) T cells. Here, CSRs are shown to promote the differentiation of mesothelin-targeting CAR T cells into central memory-li
Externí odkaz:
https://doaj.org/article/d2342c54a2474b7a9866f95bebd32b0a
Autor:
Mengjun Zhong, Rili Gao, Ruocong Zhao, Youxue Huang, Cunte Chen, Kehan Li, Xibao Yu, Dingrui Nie, Zheng Chen, Xin Liu, Zhuandi Liu, Shaohua Chen, Yuhong Lu, Zhi Yu, Liang Wang, Peng Li, Chengwu Zeng, Yangqiu Li
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-15 (2022)
Abstract Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic strategy for treating various cancers. However, response rates a
Externí odkaz:
https://doaj.org/article/c45ecc3400ef4326bb184d02bc3b711e
The Chemokine Receptor CCR8 Is a Target of Chimeric Antigen T Cells for Treating T Cell Malignancies
Autor:
Diwei Zheng, Xindong Wang, Lin Cheng, Le Qin, Zhiwu Jiang, Ruocong Zhao, Yao Li, Jingxuan Shi, Qiting Wu, Youguo Long, Suna Wang, Zhaoyang Tang, Wei Wei, Jie Yang, Yangqiu Li, Hongsheng Zhou, Qifa Liu, Pentao Liu, Xinwen Chen, Yao Yao, LiHua Yang, Peng Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chimeric antigen receptor (CAR) T cells have been successfully used in the therapy of B cell leukemia and lymphoma, but still have many challenges in their use for treating T cell malignancies, such as the lack of unique tumor antigens, their limitat
Externí odkaz:
https://doaj.org/article/0dc41a68546941458d6ffed9c0611970
Autor:
Le Qin, Ruocong Zhao, Dongmei Chen, Xinru Wei, Qiting Wu, Youguo Long, Zhiwu Jiang, Yangqiu Li, Haipeng Wu, Xuchao Zhang, Yilong Wu, Shuzhong Cui, Wei Wei, Huihui Yao, Zixia Liu, Su Cao, Yao Yao, Zhenfeng Zhang, Peng Li
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract Background Chimeric antigen receptor T cells (CAR-T cells) therapy has been well recognized for treating B cell-derived malignancy. However, the efficacy of CAR-T cells against solid tumors remains dissatisfactory, partially due to the heter
Externí odkaz:
https://doaj.org/article/7c626076eaf3451fbee582d90b26d2da
Autor:
Di Wu, Jiang Lv, Ruocong Zhao, Zhiping Wu, Diwei Zheng, Jingxuan Shi, Simiao Lin, Suna Wang, Qiting Wu, Youguo Long, Peng Li, Yao Yao
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Background Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface pro
Externí odkaz:
https://doaj.org/article/2f603940f8da4264b3bf2d33a0c99a2c
Autor:
Mengjun Zhong, Rili Gao, Ruocong Zhao, Youxue Huang, Cunte Chen, Kehan Li, Xibao Yu, Dingrui Nie, Zheng Chen, Xin Liu, Zhuandi Liu, Shaohua Chen, Yuhong Lu, Zhi Yu, Liang Wang, Peng Li, Chengwu Zeng, Yangqiu Li
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/87f6abcd84bb48a0bf765fad3c2f51db
Autor:
Ruocong Zhao, Yuanbin Cui, Yongfang Zheng, Shanglin Li, Jiang Lv, Qiting Wu, Youguo Long, Suna Wang, Yao Yao, Wei Wei, Jie Yang, Bin-Chao Wang, Zhenfeng Zhang, Hui Zeng, Yangqiu Li, Peng Li
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cell infiltration into tumors is essential for successful immunotherapy against solid tumors. Herein, we found that the expression of hyaluronic acid synthases (HAS) was negatively correlated with patient survival in multiple types of solid tumors
Externí odkaz:
https://doaj.org/article/7a2c96724a144de49c995d790558355d
Publikováno v:
Blood Science, Vol 1, Iss 2, Pp 148-155 (2019)
Abstract. Chimeric antigen receptor T (CAR-T) cells have emerged as novel and promising immune therapies for the treatment of multiple types of cancer in patients with hematological malignancies. There are several key components critical for developm
Externí odkaz:
https://doaj.org/article/277da36e9f50405e848bf02b836fbf9f
Autor:
Jiang Lv, Ruocong Zhao, Di Wu, Diwei Zheng, Zhiping Wu, Jingxuan Shi, Xinru Wei, Qiting Wu, Youguo Long, Simiao Lin, Suna Wang, Zhi Wang, Yang Li, Yantao Chen, Qing He, Suimin Chen, Huihui Yao, Zixia Liu, Zhaoyang Tang, Yao Yao, Duanqing Pei, Pentao Liu, Xuchao Zhang, Zhenfeng Zhang, Shuzhong Cui, Ren Chen, Peng Li
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background Gastric cancer (GC) is a common cancer in Asia and currently lacks a targeted therapy approach. Mesothelin (MSLN) has been reported to be expressed in GC tissue and could be targeted by chimeric antigen receptor (CAR) T cells. Mes
Externí odkaz:
https://doaj.org/article/ff188493c8c44fc3bf8bda14f41783e9