Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Ruochi Zhang"'
Autor:
Xiaopeng Xu, Tiantian Xu, Juexiao Zhou, Xingyu Liao, Ruochi Zhang, Yu Wang, Lu Zhang, Xin Gao
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 5, Pp 1043-1053 (2023)
Antibody leads must fulfill multiple desirable properties to be clinical candidates. Primarily due to the low throughput in the experimental procedure, the need for such multi-property optimization causes the bottleneck in preclinical antibody discov
Externí odkaz:
https://doaj.org/article/ebba8b9302554cf081b68e1f767e5be1
Autor:
Wenkai Han, Ningning Chen, Xinzhou Xu, Adil Sahil, Juexiao Zhou, Zhongxiao Li, Huawen Zhong, Elva Gao, Ruochi Zhang, Yu Wang, Shiwei Sun, Peter Pak-Hang Cheung, Xin Gao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The relentless evolution of SARS-CoV-2 poses a significant threat to public health, as it adapts to immune pressure from vaccines and natural infections. Gaining insights into potential antigenic changes is critical but challenging due to th
Externí odkaz:
https://doaj.org/article/8ad8dabc45b5410b92bc347c1258b550
Autor:
Xiaopeng Xu, Juexiao Zhou, Xin Gao, Yu Wang, Xingyu Liao, Zhongxiao Li, Ruochi Zhang, Chen Zhu, Qing Zhan
Publikováno v:
F1000Research, Vol 12 (2024)
Background The key challenge in drug discovery is to discover novel compounds with desirable properties. Among the properties, binding affinity to a target is one of the prerequisites and usually evaluated by molecular docking or quantitative structu
Externí odkaz:
https://doaj.org/article/58701ec4b4f14082ba5460b36cc5fa73
Autor:
Haoyang Li, Juexiao Zhou, Zhongxiao Li, Siyuan Chen, Xingyu Liao, Bin Zhang, Ruochi Zhang, Yu Wang, Shiwei Sun, Xin Gao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
This study comprehensively benchmarks 18 state-of-the-art methods for cellular deconvolution of spatial transcriptomics and provide decision-tree-style guidelines and recommendations for method selection.
Externí odkaz:
https://doaj.org/article/e0ac7957a0e843a6abfe135b377de0e7
Autor:
Chengfeng Xu, Ruochi Zhang, Meiyu Duan, Yongming Zhou, Jizhang Bao, Hao Lu, Jie Wang, Minghui Hu, Zhaoyang Hu, Fengfeng Zhou, Wenwei Zhu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 477-487 (2022)
Immune thrombocytopenia (ITP) is an autoimmune disease with the typical symptom of a low platelet count in blood. ITP demonstrated age and sex biases in both occurrences and prognosis, and adult ITP was mainly induced by the living environments. The
Externí odkaz:
https://doaj.org/article/092b26c553384d39ab3d4541a2c462d1
Publikováno v:
ACS Omega, Vol 7, Iss 4, Pp 3713-3721 (2022)
Externí odkaz:
https://doaj.org/article/0d4db24963f343ac9ccab2a944a97348
Autor:
Yuchuan Wang, Yang Zhang, Ruochi Zhang, Tom van Schaik, Liguo Zhang, Takayo Sasaki, Daniel Peric-Hupkes, Yu Chen, David M. Gilbert, Bas van Steensel, Andrew S. Belmont, Jian Ma
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract We report SPIN, an integrative computational method to reveal genome-wide intranuclear chromosome positioning and nuclear compartmentalization relative to multiple nuclear structures, which are pivotal for modulating genome function. As a pr
Externí odkaz:
https://doaj.org/article/e008eba1ec264243b115380d6b6da444
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Pulmonary hypertension (PH) is a common disease that affects the normal functioning of the human pulmonary arteries. The peripheral blood mononuclear cells (PMBCs) served as an ideal source for a minimally invasive disease diagnosis. This study hypot
Externí odkaz:
https://doaj.org/article/90bc94090dc44b459190eca1530fb50e
Autor:
Haochen Yao, Nan Zhang, Ruochi Zhang, Meiyu Duan, Tianqi Xie, Jiahui Pan, Ejun Peng, Juanjuan Huang, Yingli Zhang, Xiaoming Xu, Hong Xu, Fengfeng Zhou, Guoqing Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The recent outbreak of the coronavirus disease-2019 (COVID-19) caused serious challenges to the human society in China and across the world. COVID-19 induced pneumonia in human hosts and carried a highly inter-person contagiousness. The COVID-19 pati
Externí odkaz:
https://doaj.org/article/2c0dc0efa2b84d3fa2fe925a62a646ac
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-6 (2018)
Abstract Background Imaging is one of the major biomedical technologies to investigate the status of a living object. But the biomedical image based data mining problem requires extensive knowledge across multiple disciplinaries, e.g. biology, mathem
Externí odkaz:
https://doaj.org/article/42fe9854438f4931b43e804b8ff1d1ae