Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ruochen Zang"'
Autor:
Ziyuan Zhong, Tengkai Wang, Ruochen Zang, Yufei Zang, Yaoyao Feng, Shujun Yan, Congcong Geng, Na Zhu, Qian Wang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116086- (2024)
Gastric cancer (GC) is characterized by high tumor heterogeneity, increased surgical difficulty, and limited chemotherapy efficacy, and it is associated with a poor prognosis. The abnormal proliferation of cells involves abnormal activation of the PI
Externí odkaz:
https://doaj.org/article/684f0cf7c27e4d9d8ddb63e702c3c32b
Autor:
Seung Bum Park, Parker Irvin, Zongyi Hu, Mohsin Khan, Xin Hu, Qiru Zeng, Catherine Chen, Miao Xu, Madeleine Leek, Ruochen Zang, James Brett Case, Wei Zheng, Siyuan Ding, T. Jake Liang
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a serious threat to global public health, underscoring the urgency of developing effective therapies. Therapeutics and, m
Externí odkaz:
https://doaj.org/article/515b14c4834f43dcb95a0c60017d099a
Autor:
Juhee Son, Shimeng Huang, Qiru Zeng, Traci L. Bricker, James Brett Case, Jinzhu Zhou, Ruochen Zang, Zhuoming Liu, Xinjian Chang, Tamarand L. Darling, Jian Xu, Houda H. Harastani, Lu Chen, Maria Florencia Gomez Castro, Yongxiang Zhao, Hinissan P. Kohio, Gaopeng Hou, Baochao Fan, Beibei Niu, Rongli Guo, Paul W. Rothlauf, Adam L. Bailey, Xin Wang, Pei-Yong Shi, Elisabeth D. Martinez, Steven L. Brody, Sean P. J. Whelan, Michael S. Diamond, Adrianus C. M. Boon, Bin Li, Siyuan Ding
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Pathogenic coronaviruses are a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified small-molecule inhibitors that potently block the replication of severe acute resp
Externí odkaz:
https://doaj.org/article/9c29ed90b7cd4b61b729c1e9c1dba354
Autor:
Yuxi Lin, Ruochen Zang, Yanlong Ma, Zhuoya Wang, Li Li, Siyuan Ding, Rong Zhang, Zhiqiang Wei, Jinbo Yang, Xin Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12134 (2021)
Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (Mpro) of coronavirus plays a pivotal role in viral replication and transcripti
Externí odkaz:
https://doaj.org/article/da701b4e744d46c897ce86e4a6d134bb
Autor:
Ruochen Zang, Liang Xue, Meifang Zhang, Xiaoyue Peng, Xionghao Li, Kaixin Du, Chuanqin Shi, Yuqian Liu, Yuxi Lin, Wenwei Han, Rilei Yu, Qian Wang, Jinbo Yang, Xin Wang, Tao Jiang
Publikováno v:
European Journal of Medicinal Chemistry. 250:115184
Autor:
Alex J. B. Kreutzberger, Eylan Yutuc, Haiyan Zhao, Abhinav Diwan, Michael D. Vahey, Maria Florencia Gomez Castro, Hu Zhang, Paul W. Rothlauf, Ruochen Zang, Sheng Shen, Siyuan Ding, Sayantan Bose, Yuqin Wang, Daved H. Fremont, Kartik Mani, Gaopeng Hou, Haitao Guo, Xin Wang, Sean P. J. Whelan, James Brett Case, Xiucui Ma, Tom Kirchhausen, Michael S. Diamond, William J. Griffiths, Qiru Zeng, Juhee Son, Zhuoming Liu
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept the world in unprecedented speed. In a few months, SARS-CoV-2 has infected millions of people
Autor:
Zhiqiang Wei, Yanlong Ma, Yuxi Lin, Zhuoya Wang, Rong Zhang, Li Li, Ruochen Zang, Jinbo Yang, Siyuan Ding, Xin Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12134, p 12134 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences
Volume 22
Issue 22
Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (Mpro) of coronavirus plays a pivotal role in viral replication and transcripti
Publikováno v:
Journal of Natural Products. 82:2594-2600
Four new hydroxamate-containing natural product cyclopeptides designated acremonpeptides A-D (1-4), together with Al(III)-acremonpeptide D (5) were obtained from the marine fungus Acremonium persicinum SCSIO 115. The planar structures of 1-5 were est
Autor:
James Brett Case, Sean P. J. Whelan, Xin Wang, Qiru Zeng, Ruochen Zang, Michael S. Diamond, Juhee Son, Maria Florencia Gomez Castro, Haiyan Zhao, Zhuoming Liu, Gaopeng Hou, Paul W. Rothlauf, Siyuan Ding, Michael D. Vahey, Daved H. Fremont, Tom Kirchhausen, Sayantan Bose
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene (ISG) that shows broad antiviral activities against a wide range of enveloped viruses. Here, using an ISG screen against VSV-SARS-CoV and VSV-SARS-CoV-2 chimeric viruses, we identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d500266671b3c4959f94a3f78dd4ab46
https://doi.org/10.1101/2020.06.08.141077
https://doi.org/10.1101/2020.06.08.141077
Autor:
Xin Wang, Maria Florencia Gomez Castro, Michael S. Diamond, Siyuan Ding, Qiru Zeng, Naomi M. Sonnek, Kevin Brulois, Paul W. Rothlauf, Matthew A. Ciorba, Ruochen Zang, Zhuoming Liu, Broc T. McCune, Harry B. Greenberg, Sean P. J. Whelan
Publikováno v:
Science Immunology
Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2 replicates in the human intestine and contributes to possible fecal-oral transmission. Here, we rep