Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ruochen Jia"'
Autor:
Ruochen Jia, Leon Kutzner, Anna Koren, Kathrin Runggatscher, Peter Májek, André C. Müller, Michael Schuster, Christoph Bock, Joanna I. Loizou, Stefan Kubicek, Robert Kralovics
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 7, Pp 1-10 (2021)
Abstract Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for s
Externí odkaz:
https://doaj.org/article/54762303e96048909580862ed50205e5
Autor:
Peter Májek, Ruochen Jia, Michael Schuster, Leon Kutzner, Anna Koren, André C. Müller, Joanna I. Loizou, Robert Kralovics, Christoph Bock, Stefan Kubicek, Kathrin Runggatscher
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 7, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for small mole
Autor:
Oleh Zagrijtschuk, Harini Nivarthi, Thomas Balligand, Roman Lesyk, Ruochen Jia, Vasyl Atamanyuk, Stefan N. Constantinescu, Erica Xu, Audrey Nedelec, Leon Kutzner, Jakob Weinzierl, Stefan Kubicek, Robert Kralovics
Publikováno v:
Blood, Vol. 137, no. 14, p. 1920-1931 (2021)
Somatic mutations of calreticulin (CALR) have been identified as a main disease driver of myeloproliferative neoplasms, suggesting that development of drugs targeting mutant CALR is of great significance. Site-directed mutagenesis in the N-glycan bin
Autor:
Harini Nivarthi, Oleh Zagrijtschuk, Eva Hug, Christoph J. Binder, Cecilia Varga, Andrea Majoros, D. Tsiantoulas, Anoop Kavirayani, Sarada Achyutuni, Ruochen Jia, Christina Schueller, Michael Schuster, Christoph Bock, Martin Senekowitsch, Robert Kralovics
Publikováno v:
American journal of hematologyREFERENCES. 96(6)
Myeloproliferative neoplasms (MPNs) are characterized by a pathologic expansion of myeloid lineages. Mutations in JAK2, CALR and MPL genes are known to be three prominent MPN disease drivers. Mutant CALR (mutCALR) is an oncoprotein that interacts wit
Autor:
Stefan Kubicek, Roman Lesyk, Maryan Lelyukh, Ivanna Subtel’na, Ruochen Jia, Robert Kralovics, Anna Ringler, Oleh Zagrijtschuk, Anna Kryshchyshyn-Dylevych
Publikováno v:
Archiv der PharmazieREFERENCES. 354(4)
The data on the pharmacology of 4-thiazolidinones showed that 5-ene-2-(imino)amino-4-thiazolidinones are likely to comprise one of the most promising groups of compounds possessing anticancer properties. A series of 5-arylidene-2-(4-hydroxyphenyl)ami
Autor:
Robert Kralovics, Ruochen Jia
Publikováno v:
International journal of hematology. 111(2)
Myeloproliferative neoplasms (MPNs) are hematological diseases that are driven by somatic mutations in hematopoietic stem and progenitor cells. These mutations include JAK2, CALR and MPL mutations as the main disease drivers, mutations driving clonal
Autor:
Brian Elenbaas, Arman Esfandiari, Francesca Vena, Lindsey Crowley, Samantha Goodstal, John A. Hartley, Manuel Rodriguez-Justo, Ruochen Jia, Sakeena Syed, Juan Jose Garcia-Gomez, Jianguo Ma, Daniel Hochhauser
Publikováno v:
Oncotarget
// Francesca Vena 1, * , Ruochen Jia 1, * , Arman Esfandiari 1 , Juan J. Garcia-Gomez 1 , Manuel Rodriguez-Justo 2 , Jianguo Ma 3 , Sakeena Syed 3 , Lindsey Crowley 3 , Brian Elenbaas 3 , Samantha Goodstal 3 , John A. Hartley 1 and Daniel Hochhauser
Autor:
Andrea Majoros, Christina M. Schueller, Robert Kralovics, Ruochen Jia, Harini Nivarthi, Sarada Achyutuni, Roland Jäger
Publikováno v:
Blood. 136:20-20
Myeloproliferative neoplasms (MPNs) are a group of hematopoietic stem cell disorders driven by mutations that constitutively activate physiologic signal transduction pathways essential for hematopoiesis. The majority of patients with classical MPNs h
Autor:
Andrea Majoros, Raimund Holly, Beatrice Grabner, Eva Hug, Roland Jäger, Ruochen Jia, Chung-Wei Lee, Shin-Jye Lee, Robert Kralovics, Felix Rosebrock, Sarada Achyutuni, Harini Nivarthi
Publikováno v:
Blood. 136:53-53
The curative potential of Type I interferons for patients suffering from Myeloproliferative Neoplasms (MPNs) has been reported and these are the only class of drugs that can lead to reduction of the mutant allelic burden in patients. However, modelli
Publikováno v:
Journal of Rock Mechanics and Geotechnical Engineering, Vol 15, Iss 2, Pp 395-411 (2023)
Evaluating the fracture resistance of rocks is essential for predicting and preventing catastrophic failure of cracked structures in rock engineering. This investigation developed a brittle fracture model to predict tensile mode (mode I) failure load
Externí odkaz:
https://doaj.org/article/b840e741148a4edab6609d0adfa379ec