Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ruobi Li"'
Autor:
Ruobi Li, Wen Chen, Yongmei Xiao, Zhen Zhang, Hongmei Jiang, Ziqi Liu, Qiansheng Hu, Qing Wang, Wei Zhu, Ye Liu, Chong Chang
Publikováno v:
Journal of Applied Toxicology. 40:1683-1693
Excessive exposure to N,N-dimethylformamide (DMF) can lead to occupational liver poisoning in workers; however, the underlying mechanism is not fully clarified. The importance of microRNAs (miRNAs) in chemical-induced hepatotoxicity has been demonstr
Publikováno v:
Journal of Applied Toxicology. 40:470-482
N,N-dimethylformamide (DMF) is a colorless industrial solvent that is frequently used for chemical reactions. Epidemiologic studies and clinical case reports have consistently indicated that the main toxic effect after exposure to DMF is hepatotoxici
Autor:
Zhuo-Zhi Liang, Lu-Ying Tang, Hongmei Jiang, Ze-Fang Ren, Qian-Xin Chen, Rui-Mei Zhu, Ruobi Li, Yi-xin Zhang, Yue-Lin Li, Qing Wang
Publikováno v:
Environmental science and pollution research international. 29(15)
The antagonistic effect of selenium (Se) against cadmium (Cd)-induced breast carcinogenesis was reported, but underlying mechanisms were unclear. The aim of this study was to identify the epigenetically regulated genes and biological pathways mediati
Autor:
Ze-Fang Ren, Ruobi Li, Yue-Lin Li, Zhuo-Zhi Liang, Hongmei Jiang, Rui-Mei Zhu, Qing Wang, Lu-Ying Tang
Publikováno v:
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 64
Objectives Selenium (Se) was a potential anticancer micronutrient with proposed epigenetic effect. However, the Se-induced epigenome in breast cancer cells was yet to be studied. Methods The profiles of DNA methylation, microRNA (miRNA), long non-cod
Autor:
Zhuo-Zhi Liang, Rui-Mei Zhu, Lu-Ying Tang, Hongmei Jiang, Ruobi Li, Ze-Fang Ren, Yue-Lin Li, Qing Wang
Publikováno v:
Chemosphere. 261
Cadmium (Cd) has been confirmed to be associated with breast carcinogenesis, but the mechanism was not clarified yet. Given that epigenetic modification was speculated as underlying mechanism, we examined the differential epigenome caused by Cd in br
Autor:
Qiansheng Hu, Guoliang Li, Wen Chen, Manqi Huang, Tao Guo, Jiewei Zheng, Hongmei Jiang, Zhenlie Huang, Lihai Zeng, Weifeng Rong, Qiming Fan, Qing Wang, Fengrong Lu, Fei Wang, Ni Zeng, Dandan Xu, Ruobi Li, Ting Wang
Publikováno v:
Journal of Applied Toxicology. 38:292-303
The identification of aberrant microRNA (miRNA) expression during chemical-induced hepatic dysfunction will lead to a better understanding of the substantial role of miRNAs in liver diseases. 1,2-Dichloroethane (1,2-DCE), a chlorinated organic toxica
Autor:
Fei Wang, Hongmei Jiang, Chong Chang, Wen Chen, Ni Zeng, Yongmei Xiao, Ruobi Li, Liping Chen, Zhen Zhang, Daochuan Li, Qing Wang
Publikováno v:
Toxicology. 424
Epidemiological and experimental data have implicated the role of di(2-ethylhexyl) phthalate (DEHP) and its metabolite mono(2-ethylhexyl) phthalate (MEHP) in the pathogenesis of metabolic syndrome, including the impairment of hepatic glucose metaboli
Publikováno v:
Molecular and cellular endocrinology. 474
The thyroid hormone responsive spot 14 (THRSP) gene is a de novo lipogenesis-related gene that plays a significant role in the initiation and development of nonalcoholic fatty liver disease (NAFLD). Several previous studies had shown that endogenous
Autor:
Hongmei Jiang, Qiansheng Hu, Fei Wang, Xiumei Xing, Tao Guo, Ruobi Li, Guang-Hui Dong, Xiao-Wen Zeng, Yongmei Xiao, Ni Zeng, Ting Wang, Qing Wang, Wen Chen, Daochuan Li
Publikováno v:
Molecular genetics and genomics : MGG. 293(3)
Gene knockdown and knockout using RNAi and CRISPR/Cas9 allow for efficient evaluation of gene function, but it is unclear how the choice of technology can influence the results. To compare the phenotypes obtained using siRNA and CRISPR/Cas9 technolog