Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ruobai Sun"'
Publikováno v:
Journal of Personalized Medicine, Vol 8, Iss 2, p 13 (2018)
Oncogenic epidermal growth factor receptors (EGFRs) can recruit key effectors in diverse cellular processes to propagate oncogenic signals. Targeted and combinational therapeutic strategies have been successfully applied for treating EGFR-driven canc
Externí odkaz:
https://doaj.org/article/45fa5bb41d45433fb1f883357988e954
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78077 (2013)
Protein regulation by ubiquitin has been extensively described in model organisms. However, characterization of the ubiquitin machinery in disease vectors remains mostly unknown. This fundamental gap in knowledge presents a concern because new therap
Externí odkaz:
https://doaj.org/article/ff77b19aa1504315aaaff8d3334286a7
Publikováno v:
Journal of Personalized Medicine; Volume 8; Issue 2; Pages: 13
Journal of Personalized Medicine, Vol 8, Iss 2, p 13 (2018)
Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 8, Iss 2, p 13 (2018)
Journal of Personalized Medicine
Oncogenic epidermal growth factor receptors (EGFRs) can recruit key effectors in diverse cellular processes to propagate oncogenic signals. Targeted and combinational therapeutic strategies have been successfully applied for treating EGFR-driven canc
Autor:
Joerg Heyer, Ruobai Sun, Maria Lvova, Meaghan Russell, Jennifer E. Ring, Cheryl Eifert, Julie Y. Tse, Alexei Protopopov, Pablo Cingolani, Jia Xu, Stephen Lyle, Angeliki Pantazi
Publikováno v:
Personalized Medicine
Aim: Develop and apply a comprehensive and accurate next-generation sequencing based assay to help clinicians to match oncology patients to therapies. Materials & methods: The performance of the CANCERPLEX® assay was assessed using DNA from well-cha
Autor:
Hiroyuki Uetake, Toshifumi Wakai, Masayuki Nagahashi, Nobuaki Sato, Julie Y. Tse, Meaghan Russell, Jennifer E. Ring, Hitoshi Kameyama, Yoshifumi Shimada, Alexei Protopopov, Jun Sakata, Takashi Kobayashi, Winslow Powers, Kazuhiro Yoshida, Yiwei Ling, Hiroshi Ichikawa, Shujiro Okuda, Ruobai Sun, Shin-ei Kudo, Stephen Lyle, Joerg Heyer, Keisuke Kodama, Mitsutaka Nakada, Hiroshi Izutsu, Yuko Kitagawa, Eiji Oki, Kazuaki Takabe, Ryoma Yagi
Publikováno v:
Genome Medicine
Background Comprehensive genomic sequencing (CGS) has the potential to revolutionize precision medicine for cancer patients across the globe. However, to date large-scale genomic sequencing of cancer patients has been limited to Western populations.
Autor:
Zhen Chen, Hsien Da Huang, Michael Hsiao, Ying-Shiuan Li, Danny Ling Wang, Hongwei Zhao, Wei-Chi Wang, John Y.-J. Shyy, Hailing Jin, Yi-Hua Jan, Tsung-Ching Lai, Xiaopei Cui, Ruobai Sun, Gar-Yang Chau, Tzan Fang, Han Xiao, Feng-Mao Lin, Yun-Ting Wang, Chellappan Padmanabhan, Wei Sun
Publikováno v:
Journal of Clinical Investigation. 123:1057-1067
Despite a general repression of translation under hypoxia, cells selectively upregulate a set of hypoxia-inducible genes. Results from deep sequencing revealed that Let-7 and miR-103/107 are hypoxia-responsive microRNAs (HRMs) that are strongly induc
Autor:
Dilhan Weeraratne, Stephen Lyle, Dana Vuzman, Meaghan Russell, Jennifer E. Ring, Shermin Pei, Yajuan Li, Xiu Huang, Ruobai Sun, Andrew Bjonnes, Maria Lvova, Alexei Protopopov, Julie Y. Tse
Publikováno v:
Journal of Clinical Oncology. 36:22-22
22 Background: Tumor genomic instability is positively correlated with immunotherapy response. It confers different tumor phenotypes, including high TMB (TMB-H) and high MSI (MSI-H). Recently the US Food and Drug Administration approved MSI-H phenoty
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 1
The vacuole is the most prominent compartment in plant cells and is important for ion and protein storage. In our effort to search for key regulators in the plant vacuole sorting pathway, ribosomal large subunit 4 (rpl4d) was identified as a translat
Autor:
Cheryl Eifert, Jingrui Jiang, Ruobai Sun, Angeliki Pantazi, Joerg Heyer, Alexei Protopopov, Stephen Lyle, Meaghan Russell
Publikováno v:
Cancer Research. 77:379-379
Introduction: EGFR is a kinase of the HER/ERBB family and an oncogenic driver, especially for NSCLC, HNSCC and CRC. EGFR targeted therapies have been successfully used for treating cancer patients harboring activating EGFR mutations. However a main c
Autor:
Dana Vuzman, Ruobai Sun, Xiu Huang, Alexei Protopopov, Meaghan Russell, Cheryl Eifert, Jane Jiang, Stephen Lyle, Julie Y. Tse
Publikováno v:
Journal of Clinical Oncology. 35:e23108-e23108
e23108 Background: Immunotherapy is rapidly emerging as one of the most promising therapeutic options in clinical oncology. However, not all patients will respond to immune-oncology drugs and diagnostic assays are urgently needed to identify biomarke