Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ruo-Jun Man"'
Publikováno v:
Biosensors, Vol 11, Iss 5, p 130 (2021)
In this work, a novel fluorescent probe with first-time-selected thiazepine backbone, TZPzine-1, was developed for selective detection of hydrazine in water samples and living cells. Chosen from our recent anti-cancer agents, TZPzine-1 inferred struc
Externí odkaz:
https://doaj.org/article/72d79de52a114eccb3b8d41b365665c5
Publikováno v:
Drug Development Research. 84:110-120
In this work, a series of indole-containing pyrazole-carbohydrazide derivatives A1-A25 were synthesized, and their biological activity on tubulin polymerization inhibition and mitotic catastrophe was evaluated. For introducing indole group to CA-4 pa
Publikováno v:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 299:122840
Publikováno v:
Current Medicinal Chemistry. 28:5808-5830
Background: In the past few decades, with the abuse of antibiotics, bacterial resistance has enhanced constantly. More and more super species of bacteria, which are seriously threatening human health, have been discovered. Developing novel antibacter
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 21:825-838
Background: Along with the progress in medicine and therapies, the exploitation of anti-cancer agents focused more on the vital signaling pathways and key biological macromolecules. With rational design and advanced synthesis, quinoline derivatives h
Publikováno v:
Drug Development Research. 82:1008-1020
A series of novel indole-1,2,4-triazole derivatives have been designed, synthesized, and evaluated as potential tubulin polymerization inhibitors. The top hit 12, bearing the 3,4,5-trimethoxyphenyl moiety, exhibited substantial anti-proliferative act
Autor:
Yu-Shun Yang, Ruo-Jun Man, Jian-Fei Xu, Chao-Yue Wang, Xiao Wang, Dong-Dong Li, Hai-Liang Zhu
Publikováno v:
Journal of Molecular Structure. 1274:134455
Publikováno v:
Current topics in medicinal chemistry. 22(7)
Abstract: Flavonoids are secondary metabolites of plants. In general,most flavonoids are combined with glucosides and have extremely complex molecular structures. In the nature,these flavonoids have a variety of biological activities,such as an
Publikováno v:
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 267(Pt 1)
In this work, we chose the fluorophore Berberrubine to develop a selective probe for hydrogen polysulfide (H2Sn), and applied it into the detection in both food samples and living cells. The developed probe, HER9SS, suggested practical steadiness and
Publikováno v:
Expert Opinion on Therapeutic Patents. 29:675-688
Introduction: RAF kinase inhibitors block and regulate RAS/RAF/MEK/ERK signaling, which is a key to tumor treatment. At present, although RAF kinase inhibitors have good efficacy, there are few such drugs with low toxicity, and thus, it is urgent to