Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ruo Kai Lin"'
Autor:
Hsieh-Tsung Shen, Chin-Sheng Hung, Clilia Davis, Chih-Ming Su, Li-Min Liao, Hsiu-Ming Shih, Kuan-Der Lee, Muhamad Ansar, Ruo-Kai Lin
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 571 (2024)
Breast cancer is a leading cause of cancer mortality in women worldwide. Using the Infinium MethylationEPIC BeadChip, we analyzed plasma sample methylation to identify the SRCIN1 gene in breast cancer patients. We assessed SRCIN1-related roles and pa
Externí odkaz:
https://doaj.org/article/0673084bb3234102bbb1eac3a4244be8
Autor:
Ruo-Kai Lin, Chih-Ming Su, Shih-Yun Lin, Le Thi Anh Thu, Phui-Ly Liew, Jian-Yu Chen, Huey-En Tzeng, Yun-Ru Liu, Tzu-Hao Chang, Cheng-Yang Lee, Chin-Sheng Hung
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-20 (2022)
Abstract Background Approximately 25% of patients with early-stage breast cancer experience cancer progression throughout the disease course. Alterations in TMEM240 in breast cancer were identified and investigated to monitor treatment response and d
Externí odkaz:
https://doaj.org/article/c18ac44cbf4f4316a04a4f5d72dbce83
Autor:
Muhamad Ansar, Le Thi Anh Thu, Chin-Sheng Hung, Chih-Ming Su, Man-Hsu Huang, Li-Min Liao, Yu-Mei Chung, Ruo-Kai Lin
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Epigenetic alterations play a pivotal role in cancer treatment outcomes. Using the methylation array data and The Cancer Genome Atlas (TCGA) dataset, we observed the hypomethylation and upregulation of thiosulfate sulfurtransferase–like domain cont
Externí odkaz:
https://doaj.org/article/5a5af9d53e984acca59269764a95fe8f
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 453 (2021)
Colorectal cancer (CRC) arises from chromosomal instability, resulting from aberrant hypermethylation in tumor suppressor genes. This study identified hypermethylated genes in CRC and investigated how they affect clinical outcomes. Methylation levels
Externí odkaz:
https://doaj.org/article/e447596cd690465eb54c078b097b1933
Autor:
Sheng-Chao Wang, Li-Min Liao, Muhamad Ansar, Shih-Yun Lin, Wei-Wen Hsu, Chih-Ming Su, Yu-Mei Chung, Cai-Cing Liu, Chin-Sheng Hung, Ruo-Kai Lin
Publikováno v:
Cancers, Vol 13, Iss 6, p 1375 (2021)
The early detection of cancer can reduce cancer-related mortality. There is no clinically useful noninvasive biomarker for early detection of breast cancer. The aim of this study was to develop accurate and precise early detection biomarkers and a dy
Externí odkaz:
https://doaj.org/article/5b4d946a33954fe3b62268389c0fb94b
Autor:
Muhamad Ansar, Chun-Jung Wang, Yu-Han Wang, Tsung-Hua Shen, Chin-Sheng Hung, Shih-Ching Chang, Ruo-Kai Lin
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7395 (2020)
The incidence and mortality rates of colorectal cancer (CRC) have been high in recent years. Prevention and early detection are crucial for decreasing the death rate. Therefore, this study aims to characterize the alteration patterns of mothers again
Externí odkaz:
https://doaj.org/article/761d08302aff4b9cbdb4d245d91941f3
Publikováno v:
Journal of Cancer Research and Practice, Vol 1, Iss 1, Pp 14-27 (2014)
Background: Overexpression of DNA 5’-cytosine-methyltransferases (DNMTs), which silence genes including tumor suppressor genes, is involved in many cancers. However, the mechanism of DNMT overexpression remains mostly unclear. Objectives: The tumor
Externí odkaz:
https://doaj.org/article/53705e707a6f4aba91a24e703237537e
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3096 (2018)
Lung and breast cancer are the leading causes of mortality in women worldwide. The discovery of molecular alterations that underlie these two cancers and corresponding drugs has contributed to precision medicine. We found that CCND2 is a common targe
Externí odkaz:
https://doaj.org/article/3bc3df0c5daa427c89fad4f633e403b0
Autor:
Yu-Jia Chang, Ya-Wen Cheng, Ruo-Kai Lin, Chi-Chou Huang, William Tzu-Liang Chen, Tao-Wei Ke, Po-Li Wei
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160550 (2016)
Treatment resistance and metastasis are the major causes of death among patients with colorectal cancer (CRC). Approximately 20% of surgically treated patients ultimately develop metastases during the follow-up period. Currently, the TNM system is th
Externí odkaz:
https://doaj.org/article/cee6ec4f849a4b3985476b3916422f25
Autor:
Chih-Hung Hsu, Kai-Lin Peng, Ming-Lun Kang, Yi-Ren Chen, Yu-Chih Yang, Chin-Hsien Tsai, Chi-Shuen Chu, Yung-Ming Jeng, Yen-Ting Chen, Feng-Mao Lin, Hsien-Da Huang, Yun-Yuh Lu, Yu-Ching Teng, Shinn-Tsuen Lin, Ruo-Kai Lin, Fan-Mei Tang, Sung-Bau Lee, Huan Ming Hsu, Jyh-Cherng Yu, Pei-Wen Hsiao, Li-Jung Juan
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 568-579 (2012)
Tumor suppressor gene silencing through cytosine methylation contributes to cancer formation. Whether DNA demethylation enzymes counteract this oncogenic effect is unknown. Here, we show that TET1, a dioxygenase involved in cytosine demethylation, is
Externí odkaz:
https://doaj.org/article/d98b7b9806cf4e1eb2311e05786689da