Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Runzhen, Zhao"'
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Background Acute lung injury is characterized by overwhelmingly elevated PAI-1 in both lung edema fluid and the circulating system. The role of increased PAI-1, encoded by Serpine1 gene, in the regeneration of injured lung epithelium has not
Externí odkaz:
https://doaj.org/article/013c1d4f56174a79b79d8bcf29d2b68d
Autor:
Hong-Long Ji, Nan Mile S. Xi, Chandra Mohan, Xiting Yan, Krishan G. Jain, Qun Sophia Zang, Vivian Gahtan, Runzhen Zhao
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Sarcoidosis is a chronic granulomatous disorder characterized by unknown etiology, undetermined mechanisms, and non-specific therapies except TNF blockade. To improve our understanding of the pathogenicity and to predict the outcomes of the disease,
Externí odkaz:
https://doaj.org/article/5eed752bbab34a1c94379bfc9a370040
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-10 (2022)
Abstract Background The cGMP-dependent type 2 protein kinase, encoded by the prkg2 gene, is highly expressed in alveolar type 2 epithelial (AT2) cells. It is unclear whether prkg2 regulates AT2 cell homeostasis and re-alveolarization of injured lungs
Externí odkaz:
https://doaj.org/article/c610ef542b234f84969095b09d3fbfa9
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 3034 (2023)
Lung diseases rank third in terms of mortality and represent a significant economic burden globally. Scientists have been conducting research to better understand respiratory diseases and find treatments for them. An ideal in vitro model must mimic t
Externí odkaz:
https://doaj.org/article/45b7e95df37440f79db0be0251a7e891
Autor:
Gibran Ali, Mo Zhang, Runzhen Zhao, Krishan G. Jain, Jianjun Chang, Satoshi Komatsu, Beiyun Zhou, Jiurong Liang, Michael A. Matthay, Hong-Long Ji
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/d1200fc8b8b94d06a3d3fef480b88445
Autor:
Runzhen Zhao, Zhenlei Su, Andrey A. Komissarov, Shan-Lu Liu, Guohua Yi, Steven Idell, Michael A. Matthay, Hong-Long Ji
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundDynamic D-dimer level is a key biomarker for the severity and mortality of COVID-19 (coronavirus disease 2019). How aberrant fibrinolysis influences the clinical progression of COVID-19 presents a clinicopathological dilemma challenging int
Externí odkaz:
https://doaj.org/article/d1db92eab41f418699df252ca43ca716
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L515-L524
Failure to regenerate injured alveoli functionally and promptly causes a high incidence of fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator inhibitor-1 (PAI-1) regulates the lineage of alveolar type 2 (AT2) cells fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7d88fd13d88c42f7f81d5d0549939c
https://doi.org/10.1152/ajplung.00202.2022
https://doi.org/10.1152/ajplung.00202.2022
Publikováno v:
Cellular Physiology and Biochemistry, Vol 44, Iss 3, Pp 1120-1132 (2017)
Epithelial sodium channels (ENaC) play an important role in re-absorbing excessive luminal fluid by building up an osmotic Na+ gradient across the tight epithelium in the airway, the lung, the kidney, and the colon. The ENaC is a major pathway for re
Externí odkaz:
https://doaj.org/article/7efdad14e4bc4b4eb4563ef29495e984
Autor:
Bingxin Guo, Yichun Bai, Yana Ma, Cong Liu, Song Wang, Runzhen Zhao, Jiaxing Dong, Hong-Long Ji
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 13 (2019)
Smoke-inhalation-induced acute lung injury (SI-ALI) is a leading cause of morbidity and mortality in victims of fire tragedies. SI-ALI contributes to an estimated 30% of burn-caused patient deaths, and recently, more attention has been paid to the sp
Externí odkaz:
https://doaj.org/article/800992144a1248d896e043cd97c77e1d
Autor:
Cong Liu, Yana Ma, Zhenlei Su, Runzhen Zhao, Xiaoli Zhao, Hong-Guang Nie, Ping Xu, Lili Zhu, Mo Zhang, Xiumin Li, Xiaoju Zhang, Michael A. Matthay, Hong-Long Ji
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BackgroundAcute lung injury (ALI) is characterized by suppressed fibrinolytic activity in bronchoalveolar lavage fluid (BALF) attributed to elevated plasminogen activator inhibitor-1 (PAI-1). Restoring pulmonary fibrinolysis by delivering tissue-type
Externí odkaz:
https://doaj.org/article/8caac9b5e7c243bbabc4774b4bc5cb01