Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Runxiang Zhao"'
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: 5-Hydroxymethylcytosine (5hmC) binding, ES-cell-specific (HMCES) crosslinks to apurinic or apyrimidinic (AP, abasic) sites in single-strand DNA (ssDNA). To determine whether HMCES responds to the ssDNA abasic site in cells, we exploited the
Externí odkaz:
https://doaj.org/article/6e8354df0adf471f81cf26a8baba5860
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99397 (2014)
Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 cre
Externí odkaz:
https://doaj.org/article/02b19fd7ea9e4355a8c0f3b1cd9b3b13
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63149 (2013)
SMARCAL1 is an ATPase in the SNF2 family that functions at damaged replication forks to promote their stability and restart. It acts by translocating on DNA to catalyze DNA strand annealing, branch migration, and fork regression. Many SNF2 enzymes wo
Externí odkaz:
https://doaj.org/article/6a33b654f0d243c48227b01b10e41a31
Autor:
Kavi P. M. Mehta, Vaughn Thada, Runxiang Zhao, Archana Krishnamoorthy, Micheal Leser, Kristie Lindsey Rose, David Cortez
Publikováno v:
Science Advances. 8
Replication-coupled DNA repair and damage tolerance mechanisms overcome replication stress challenges and complete DNA synthesis. These pathways include fork reversal, translesion synthesis, and repriming by specialized polymerases such as PRIMPOL. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd56af36d57ec5e3fb1b2d550326499
https://doi.org/10.1126/sciadv.abm0314
https://doi.org/10.1126/sciadv.abm0314
Publikováno v:
Cell reports
Cell Reports, Vol 31, Iss 9, Pp-(2020)
Cell Reports, Vol 31, Iss 9, Pp-(2020)
SUMMARY 5-Hydroxymethylcytosine (5hmC) binding, ES-cell-specific (HMCES) crosslinks to apurinic or apyrimidinic (AP, abasic) sites in single-strand DNA (ssDNA). To determine whether HMCES responds to the ssDNA abasic site in cells, we exploited the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8259023375c907c76ab177e1f9934b04
http://europepmc.org/articles/PMC7313144
http://europepmc.org/articles/PMC7313144
Autor:
Manuel Ascano, M. Shane Hutson, Runxiang Zhao, Kareem N. Mohni, David Cortez, Monica E. Lacy, Gina Kavanaugh, Yan Guo, Gloria G. Glick
Publikováno v:
Molecular and Cellular Biology. 35:2979-2990
Accurate replication of DNA is imperative for the maintenance of genomic integrity. We identified Enhancer of Rudimentary Homolog (ERH) using a whole-genome RNA interference (RNAi) screen to discover novel proteins that function in the replication st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084d792239f4e46f5653535e7132af7d
https://doi.org/10.1128/mcb.01276-14
https://doi.org/10.1128/mcb.01276-14
Autor:
Sarah R. Wessel, Aditya A. Sathe, David Cortez, Runxiang Zhao, Shyam K. Sharan, Huzefa Dungrawala, Xia Ding, Remy Le Meur, Kamakoti P. Bhat, Walter J. Chazin
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2017, 67 (3), pp.374-386.e5. ⟨10.1016/j.molcel.2017.06.023⟩
Molecular Cell, Elsevier, 2017, 67 (3), pp.374-386.e5. ⟨10.1016/j.molcel.2017.06.023⟩
RAD51 promotes homology-directed repair (HDR), replication fork reversal, and stalled fork protection. Defects in these functions cause genomic instability and tumorigenesis but also generate hypersensitivity to cancer therapeutics. Here we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502b2c27130f4dc296fc35e86bfd21a8
https://europepmc.org/articles/PMC5548441/
https://europepmc.org/articles/PMC5548441/
Autor:
Brandt F. Eichman, Jessica W. Luzwick, Kareem N. Mohni, Sarah R. Wessel, David Cortez, Kavi P.M. Mehta, Petria S. Thompson, Andrea C. Wojciechowski, Runxiang Zhao, Hillary M. Layden
Publikováno v:
Cell. 176:144-153.e13
Abasic sites are one of the most common DNA lesions. All known abasic site repair mechanisms operate only when the damage is in double-stranded DNA. Here, we report the discovery of 5-hydroxymethylcytosine (5hmC) binding, ESC-specific (HMCES) as a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d812cd664a03b6e10188a4fad551d19a
https://doi.org/10.1016/j.cell.2018.10.055
https://doi.org/10.1016/j.cell.2018.10.055
Publikováno v:
Journal of Biological Chemistry. 286:37320-37327
ATR (ataxia telangiectasia-mutated and Rad3-related) contains 16 conserved candidate autophosphorylation sites that match its preferred S/TQ consensus. To determine whether any is functionally important, we mutated the 16 candidate residues to alanin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad60c195141bfc63d23b9a4bba0620e9
https://doi.org/10.1074/jbc.m111.276113
https://doi.org/10.1074/jbc.m111.276113
Autor:
David B. Friedman, Runxiang Zhao, David Cortez, Gloria G. Glick, Carol E. Bansbach, Edward A. Nam
Publikováno v:
Journal of Biological Chemistry. 286:28707-28714
The DNA damage response kinases ataxia telangiectasia-mutated (ATM), DNA-dependent protein kinase (DNA-PK), and ataxia telangiectasia-mutated and Rad3-related (ATR) signal through multiple pathways to promote genome maintenance. These related kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebeee33e321bf24d30332717b803aa5
https://doi.org/10.1074/jbc.m111.248914
https://doi.org/10.1074/jbc.m111.248914