Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.

Autor: Runtsch MC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: runtschm@tcd.ie., Angiari S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Wadhwa R; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia., Zhang Y; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China., Zheng Y; Drug Discovery Science & Technology, AbbVie Inc., 1 North Waukegon Road, North Chicago, IL 60064, USA., Spina JS; AbbVie, Bio Research Center, 100 Research Drive, Worcester, MA 01608, USA., Ruzek MC; AbbVie, Bio Research Center, 100 Research Drive, Worcester, MA 01608, USA., Argiriadi MA; AbbVie, Bio Research Center, 100 Research Drive, Worcester, MA 01608, USA., McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Mendez RS; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Zotta A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Peace CG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Walsh A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Chirillo R; Department of Experimental and Clinical Medicine, 'Magna Græcia' University of Catanzaro, Catanzaro, Italy., Hams E; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Fallon PG; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Jayamaran R; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia., Dua K; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia., Brown AC; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Kim RY; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Horvat JC; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Hansbro PM; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Wang C; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: laoneill@tcd.ie.

Publikováno v: Cell metabolism [Cell Metab] 2022 Mar 01; Vol. 34 (3), pp. 487-501.e8.

A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages.

Autor: Huffaker TB; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Ekiz HA; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Barba C; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Lee SH; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Runtsch MC; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Nelson MC; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Bauer KM; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Tang WW; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA., Mosbruger TL; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Cox JE; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.; Metabolomics Core Research Facility, University of Utah, Salt Lake City, UT, USA., Round JL; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Voth WP; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA. warren.voth@path.utah.edu., O'Connell RM; Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA. ryan.oconnell@path.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. ryan.oconnell@path.utah.edu.

Publikováno v: Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2620. Date of Electronic Publication: 2021 May 11.

Pseudomonas Persists by Feeding off Itaconate.

Autor: Runtsch MC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02R590, Ireland., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02R590, Ireland. Electronic address: laoneill@tcd.ie.

Publikováno v: Cell metabolism [Cell Metab] 2020 Jun 02; Vol. 31 (6), pp. 1045-1047.

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.

Autor: Hughes MM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Angiari S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Tummala P; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Zaslona Z; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Runtsch MC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Sutton CE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Diskin C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Rooke M; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Takahashi S; Department of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan., Sundararaj S; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Casarotto MG; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Dahlstrom JE; ACT Pathology and ANU Medical School, The Canberra Hospital, Canberra, ACT, Australia., Palsson-McDermott EM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Corr SC; Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland., Mills KHG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Preston RJS; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Neamati N; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 2800 Plymouth Road, Building 520, Room 1363, Ann Arbor, MI 48109, USA; Translational Oncology Program, University of Michigan, 2800 Plymouth Road, Building 520, Room 1363, Ann Arbor, MI 48109, USA., Xie Y; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Baell JB; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Board PG; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.

Publikováno v: Cell reports [Cell Rep] 2019 Oct 01; Vol. 29 (1), pp. 151-161.e5.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Autor: Mills EL; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK., Ryan DG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Dikovskaya D; Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Menon D; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Zaslona Z; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Jedrychowski MP; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Costa ASH; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK., Higgins M; Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Hams E; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Szpyt J; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Runtsch MC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., King MS; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., McGouran JF; School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Fischer R; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK., Kessler BM; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK., McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Hughes MM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Carroll RG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK., Booty LM; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Knatko EV; Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Meakin PJ; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Ashford MLJ; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Modis LK; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK., Brunori G; GlaxoSmithKline, Park Road, Ware, Hertfordshire, UK., Sévin DC; Cellzome, GlaxoSmithKline R&D, Heidelberg, Germany., Fallon PG; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Caldwell ST; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK., Kunji ERS; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Chouchani ET; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Frezza C; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK., Dinkova-Kostova AT; Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Hartley RC; WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., O'Neill LA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; GlaxoSmithKline, Gunnelswood Road, Stevenage, Hertfordshire, UK.

Publikováno v: Nature [Nature] 2018 Apr 05; Vol. 556 (7699), pp. 113-117. Date of Electronic Publication: 2018 Mar 28.