Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout

Autor: Huan Zhang, Liu Yuqiang, Xie Yafei, Zhao Guilong, Ling Yin, Wu Jingwei, Runling Wang

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:383-388

As a part of our ongoing research to develop novel URAT1 inhibitors, 19 compounds (1a-1s) based on carboxylic acid bioisosteres were synthesized and tested for in vitro URAT1 inhibitor activity (IC50). The structure-activity relationship (SAR) explor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b06d1026a2d76d7876070eb3abc5e4
https://doi.org/10.1016/j.bmcl.2018.12.036

Exploring the cause of the dual allosteric targeted inhibition attaching to allosteric sites enhancing SHP2 inhibition.

Autor: Yangchun, Ma, WenYu, Yang, Liang, Zhou, LiPeng, Li, JingWei, Wu, WeiYa, Li, Shan, Du, Ying, Ma, RunLing, Wang

Publikováno v: Molecular Diversity; Jun2022, Vol. 26 Issue 3, p1567-1580, 14p

N,N′-Diacetyl-N′-[(4-nitrophenoxy)acetyl]acetohydrazide

Autor: Runling Wang, Guilong Zhao, Weiren Xu, Zhifeng Wang, Xiao Hu

Publikováno v: Acta Crystallographica Section E, Vol 65, Iss 2, Pp o372-o372 (2009)

The asymmetric unit of the title compound, C14H15N3O7, contains two independent molecules which are linked into a pseudocentrosymmetric dimer by a π–π interaction, as shown by the short distance of 3.722 (5) Å between the centroids of the benzen

Externí odkaz: https://doaj.org/article/1b054e6653144065b4c12e2dd639c35d

The Sixth Visual Object Tracking VOT2018 Challenge Results

Autor: Houqiang Li, Huchuan Lu, Siwen Wang, Rafael Martin-Nieto, Efstratios Gavves, Feng Li, Manqiang Che, Erhan Gundogdu, Priya Mariam Raju, Xiaofan Zhang, Roman Pflugfelder, Yan Lu, Xinmei Tian, Martin Danelljan, Deepak Mishra, Guilherme Sousa Bastos, Honggang Zhang, Heng Fan, Mohamed H. Abdelpakey, Zhen-Hua Feng, Wang Wei, Andrej Muhič, Wengang Zhou, Deming Chen, Haojie Zhao, Sihang Wu, Richard M. Everson, Junfei Zhuang, Qin Zhou, Myunggu Kang, Abel Gonzalez-Garcia, Pablo Vicente-Moñivar, Richard Bowden, Horst Possegger, Yicai Yang, Andrea Vedaldi, Jaime Spencer Martin, Jongwon Choi, Yunhua Zhang, Yiannis Demiris, Seokeon Choi, Alireza Memarmoghadam, Wangmeng Zuo, Changzhen Xiong, Yuxuan Sun, Daijin Kim, Yuhong Li, Qing Guo, Tang Ming, Arnold W. M. Smeulders, Hamed Kiani Galoogahi, Zhihui Wang, Asanka G. Perera, Fahad Shahbaz Khan, George De Ath, Shuangping Huang, Qian Ruihe, Philip H. S. Torr, Haojie Li, Zhiqun He, João F. Henriques, Namhoon Lee, Chong Sun, Jorge Rodríguez Herranz, Vincenzo Santopietro, Lijun Wang, Qiang Wang, Gustavo Fernandez, Shuai Bai, Weiming Hu, Ondrej Miksik, Dongyoon Wee, Xiaohe Wu, Goutam Bhat, Yifan Jiao, A. Aydin Alatan, Alfredo Petrosino, Ran Tao, Tianyang Xu, Sergio Vivas, Cheng Tian, Yee Wei Law, Wei Feng, José M. Martínez, Luca Bertinetto, Runling Wang, Liu Si, Tianzhu Zhang, Tomas Vojir, Mario Edoardo Maresca, Lichao Zhang, Changick Kim, Luka Čehovin Zajc, Lingxiao Yang, Yan Li, Javaan Chahl, Simon Hadfield, Chong Luo, Jiří Matas, Ales Leonardis, Jack Valmadre, Pedro Senna, Josef Kittler, Klemen Grm, Cong Hao, Haibin Ling, Isabela Drummond, Zheng Zhang, Fan Yang, Joakim Johnander, Tobias Fischer, Gorthi R. K. Sai Subrahmanyam, Jinyoung Sung, Jin-Young Choi, Bo Li, Hui Zhi, Álvaro Iglesias-Arias, Joost van de Weijer, Hyung Jin Chang, Jinqing Qi, Michael Felsberg, Francesco Battistone, Sangdoo Yun, Wei Zou, Huiyun Li, Boyu Chen, Zheng Zhu, Jing Li, Abdelrahman Eldesokey, Litu Rout, Matej Kristan, Mohamed Shehata, Fei Zhao, Changsheng Xu, Alan Lukežič, Yi Wu, Wenjun Zeng, Lutao Chu, Vitomir Struc, Stuart Golodetz, Alvaro Garcia-Martin, Dong Wang, Junyu Gao, Hankyeol Lee, Hyemin Lee, Ning Wang, Wei Wu, Anfeng He, Xiaojun Wu, Rama Krishna Sai Subrahmanyam Gorthi, Payman Moallem, Peixia Li, Jinqiao Wang, Erik Velasco-Salido, Ming-Hsuan Yang

Publikováno v: European Conference on Computer Vision
Lecture Notes in Computer Science ISBN: 9783030110086
ECCV Workshops (1)

The Visual Object Tracking challenge VOT2018 is the sixth annual tracker benchmarking activity organized by the VOT initiative. Results of over eighty trackers are presented; many are state-of-the-art trackers published at major computer vision confe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a449874fbb7a60c1bc50564cd356140f
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-161343

Study of SHP-2 ( PTPN11 ) allosterism on structural movement using solution perturbed molecular dynamics simulation

Autor: Xiaobo Li, Runling Wang, Wei-Ren Xu, Chenglung Chen, Soumitra S. Bhuyan, Lei Dong

Publikováno v: Journal of Molecular Liquids. 223:509-515

Src-homology2 (SH2) domain-containing protein tyrosine phosphatase-2 (SHP-2) is a ubiquitously expressed protein-tyrosine phosphatase. SHP-2 is linked to human diseases and plays broad roles in cancer pathogenesis. Activity of the SHP-2 catalytic dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f441909586f527d81aacc5629eb7fd0
https://doi.org/10.1016/j.molliq.2016.08.070