Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Runhui Lu"'
Autor:
Runhui Lu, Yafan Zhang, Ran Chen, Lian Li, Caihu Huang, Zihan Zhou, Yingting Cao, Hongyan Li, Junya Li, Yixin Zhang, Yanli Wang, Jian Huang, Xian Zhao, Jing Feng, Jianxiu Yu, Chunling Du
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 59, Iss , Pp 101082- (2025)
The KRAS/ERK pathway is crucial in cancer progression and chemotherapy resistance, yet its upstream regulatory mechanism remains elusive. We identified MSI2 as a new promoter of chemotherapy resistance in cancers. MSI2 directly binds to a specific cl
Externí odkaz:
https://doaj.org/article/f327cd41a7134e4dafa9e8d3e381f497
Autor:
Xiaojia Liu, Runhui Lu, Qianqian Yang, Jianfeng He, Caihu Huang, Yingting Cao, Zihan Zhou, Jiayi Huang, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Ruiyu Xie, Xian Zhao, Jianxiu Yu
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 170-189 (2024)
Endoribonuclease DICER is an RNase III enzyme that mainly processes microRNAs in the cytoplasm but also participates in nuclear functions such as chromatin remodelling, epigenetic modification and DNA damage repair. The expression of nuclear DICER is
Externí odkaz:
https://doaj.org/article/08e7cbeac8cb4d8e967a197af94d9b90
Autor:
Xian Zhao, Yingting Cao, Runhui Lu, Zihan Zhou, Caihu Huang, Lian Li, Jiayi Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Junke Zheng, Yujie Fu, Jianxiu Yu
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Non‐small‐cell lung cancer (NSCLC) is a highly lethal tumor that often develops resistance to targeted therapy. It is shown that Tank‐binding kinase 1 (TBK1) phosphorylates AGO2 at S417 (pS417‐AGO2), which promotes NSCLC progression
Externí odkaz:
https://doaj.org/article/b52bb434766f4888b2363bcc83ae8ad5
Autor:
Hailong Zhang, Xian Zhao, Yanmin Guo, Ran Chen, Jianfeng He, Lian Li, Zhe Qiang, Qianqian Yang, Xiaojia Liu, Caihu Huang, Runhui Lu, Jiayu Fang, Yingting Cao, Jiayi Huang, Yanli Wang, Jian Huang, Guo-Qiang Chen, Jinke Cheng, Jianxiu Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Met1-linked linear ubiquitination (M1-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M1-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA targe
Externí odkaz:
https://doaj.org/article/8322c7884bf545219a1b04b3f0a7aff7
Autor:
Jiayu Fang, Yuqin Zhang, Caihu Huang, Runhui Lu, Jie Yu, Ran Chen, Yanli Wang, Xian Zhao, Jianxiu Yu, Jian Huang
Publikováno v:
Oncogene. 42:1058-1071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::045b67bdecdf54a510493a16fa9b97f2
https://doi.org/10.1038/s41388-023-02622-9
https://doi.org/10.1038/s41388-023-02622-9
Autor:
Yingting Cao, Jianfeng He, Yanmin Guo, Jiayi Huang, Xian Zhao, Runhui Lu, Guo-Qiang Chen, Ran Chen, Hailong Zhang, Jian Huang, Xiaojia Liu, Jianxiu Yu, Zhe Qiang, Jinke Cheng, Qianqian Yang, Lian Li, Caihu Huang, Jiayu Fang, Yanli Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ce600cfd403a14a456d0476430e40e
https://doi.org/10.1038/s41467-021-25739-5
https://doi.org/10.1038/s41467-021-25739-5
Autor:
Xian Zhao, Xiaojia Liu, Jianxiu Yu, Caihu Huang, Lian Li, Ran Chen, Bin Jiang, Qianqian Yang, Yanli Wang, Runhui Lu, Guofang Hou
Publikováno v:
Nucleic Acids Research
N 6-Methyladenosine (m6A) is the most abundant modification within diverse RNAs including mRNAs and lncRNAs and is regulated by a reversible process with important biological functions. Human YTH domain family 2 (YTHDF2) selectively recognized m6A-RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706fa6306543e1797b3b9e0e045fdc1b
https://pubmed.ncbi.nlm.nih.gov/33577677
https://pubmed.ncbi.nlm.nih.gov/33577677
Autor:
Hailong, Zhang, Xian, Zhao, Yanmin, Guo, Ran, Chen, Jianfeng, He, Lian, Li, Zhe, Qiang, Qianqian, Yang, Xiaojia, Liu, Caihu, Huang, Runhui, Lu, Jiayu, Fang, Yingting, Cao, Jiayi, Huang, Yanli, Wang, Jian, Huang, Guo-Qiang, Chen, Jinke, Cheng, Jianxiu, Yu
Publikováno v:
Nature communications. 12(1)
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdfdc90028bc36e3a817e90375971c14
https://pubmed.ncbi.nlm.nih.gov/34518544
https://pubmed.ncbi.nlm.nih.gov/34518544