Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Runhong Zhou"'
Autor:
Mengxiao Luo, Runhong Zhou, Bingjie Tang, Hang Liu, Bohao Chen, Na Liu, Yufei Mo, Pengfei Zhang, Ye Lim Lee, Jonathan Daniel Ip, Allen Wing-Ho Chu, Wan-Mui Chan, Hiu-On Man, Yuting Chen, Kelvin Kai-Wang To, Kwok-Yung Yuen, Shangyu Dang, Zhiwei Chen
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105354- (2024)
Summary: Background: The spread of emerging SARS-CoV-2 immune escape sublineages, especially JN.1 and KP.2, has resulted in new waves of COVID-19 globally. The evolving memory B cell responses elicited by the parental Omicron variants to subvariants
Externí odkaz:
https://doaj.org/article/d26a7daabd354e91b2e59e929858c0b6
Autor:
Yufei Mo, Ming Yue, Lok Yan Yim, Runhong Zhou, Chunhao Yu, Qiaoli Peng, Ying Zhou, Tsz-Yat Luk, Grace Chung-Yan Lui, Huarong Huang, Chun Yu Hubert Lim, Hui Wang, Li Liu, Hongzhe Sun, Jun Wang, Youqiang Song, Zhiwei Chen
Publikováno v:
EBioMedicine, Vol 98, Iss , Pp 104877- (2023)
Summary: Background: HIV-1-associated immune activation drives CD4+ T cell depletion and the development of acquired immunodeficiency syndrome. We aimed to determine the role of nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide
Externí odkaz:
https://doaj.org/article/54e9a91cd4604b2a9a8e451b41efab99
Autor:
Biao Zhou, Runhong Zhou, Jasper Fuk-Woo Chan, Jianwei Zeng, Qi Zhang, Shuofeng Yuan, Li Liu, Rémy Robinot, Sisi Shan, Na Liu, Jiwan Ge, Hugo Yat-Hei Kwong, Dongyan Zhou, Haoran Xu, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Hin Chu, Ming Yue, Ka-Yi Kwan, Chun-Yin Chan, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, Zhenglong Du, Ka-Kit Au, Haode Huang, Hiu-On Man, Jianli Cao, Cun Li, Ziyi Wang, Jie Zhou, Youqiang Song, Man-Lung Yeung, Kelvin Kai-Wang To, David D. Ho, Lisa A. Chakrabarti, Xinquan Wang, Linqi Zhang, Kwok-Yung Yuen, Zhiwei Chen
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Prevention of robust severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in nasal turbinate (NT) requires in vivo evaluation of IgA neutralizing antibodies. Here, we report the efficacy of receptor binding domain (RBD)-specific mon
Externí odkaz:
https://doaj.org/article/06e5de52ccad4802879063fc0fd250b8
Autor:
Mengxiao Luo, Biao Zhou, Eswar R. Reddem, Bingjie Tang, Bohao Chen, Runhong Zhou, Hang Liu, Lihong Liu, Phinikoula S. Katsamba, Ka-Kit Au, Hiu-On Man, Kelvin Kai-Wang To, Kwok-Yung Yuen, Lawrence Shapiro, Shangyu Dang, David D. Ho, Zhiwei Chen
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTIncreasing spread by SARS-CoV-2 Omicron variants challenges existing vaccines and broadly reactive neutralizing antibodies (bNAbs) against COVID-19. Here we determine the diversity, potency, breadth and structural insights of bNAbs derived fr
Externí odkaz:
https://doaj.org/article/e951ddcfe32c4425a17c8d0af05f3290
Autor:
Shaofeng Deng, Ying Liu, Rachel Chun-Yee Tam, Pin Chen, Anna Jinxia Zhang, Bobo Wing-Yee Mok, Teng Long, Anja Kukic, Runhong Zhou, Haoran Xu, Wenjun Song, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Zhiwei Chen, Kwok-Yung Yuen, Pui Wang, Honglin Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Current available vaccines for COVID-19 are effective in reducing severe diseases and deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next-generation vaccines which are able to induce mucosal immunity in the u
Externí odkaz:
https://doaj.org/article/eb113c5b4935434fb1994bc3b01d47f8
Autor:
Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F.J. Purcell, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104574- (2023)
Summary: Background: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during sto
Externí odkaz:
https://doaj.org/article/3f8a77f37e1f498db21c0e05005ef2d3
Autor:
Biao Zhou, Runhong Zhou, Bingjie Tang, Jasper Fuk-Woo Chan, Mengxiao Luo, Qiaoli Peng, Shuofeng Yuan, Hang Liu, Bobo Wing-Yee Mok, Bohao Chen, Pui Wang, Vincent Kwok-Man Poon, Hin Chu, Chris Chung-Sing Chan, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Ka-Kit Au, Hiu-On Man, Lu Lu, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen, Shangyu Dang, Zhiwei Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicro
Externí odkaz:
https://doaj.org/article/36f166867713422db16d612a9572ffc2
Autor:
Runhong Zhou, Na Liu, Xin Li, Qiaoli Peng, Cheuk-Kwan Yiu, Haode Huang, Dawei Yang, Zhenglong Du, Hau-Yee Kwok, Ka-Kit Au, Jian-Piao Cai, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To, Xiaoning Xu, Kwok-Yung Yuen, Zhiwei Chen
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 32, Iss , Pp 100660- (2023)
Summary: Background: The ongoing outbreak of SARS-CoV-2 Omicron BA.2 infections in Hong Kong, the model city of universal masking of the world, has resulted in a major public health crisis. Although the third vaccination resulted in strong boosting o
Externí odkaz:
https://doaj.org/article/cb5b671b51044daca703827ccfd6a568
Autor:
Tianyu Cao, Li Liu, Kelvin Kai‐Wang To, Chun‐Yu Lim, Runhong Zhou, Yue Ming, Ka‐Yi Kwan, Sulan Yu, Chun‐Yin Chan, Biao Zhou, Haode Huang, Yufei Mo, Zhenglong Du, Ruomei Gong, Luk‐Tsz Yat, Ivan Fan‐Ngai Hung, Anthony Raymond Tam, Wing‐Kin To, Wai‐Shing Leung, Thomas Shiu‐Hong Chik, Owen Tak‐Yin Tsang, Xiang Lin, You‐qiang Song, Kwok‐Yung Yuen, Zhiwei Chen
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Abstract Background Patients with COVID‐19 display a broad spectrum of manifestations from asymptomatic to life‐threatening disease with dysregulated immune responses. Mechanisms underlying the detrimental immune responses and disease severity re
Externí odkaz:
https://doaj.org/article/420b4fc9f1d04ed2908ca6fed814d0d2
Autor:
Pui Wang, Siu-Ying Lau, Shaofeng Deng, Pin Chen, Bobo Wing-Yee Mok, Anna Jinxia Zhang, Andrew Chak-Yiu Lee, Kwok-Hung Chan, Rachel Chun-Yee Tam, Haoran Xu, Runhong Zhou, Wenjun Song, Li Liu, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Zhiwei Chen, Kwok-Yung Yuen, Honglin Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replica
Externí odkaz:
https://doaj.org/article/5ab058d1b50b45a8b2e9e5a270db4d74