Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rune Troelsgaard Pedersen"'
Autor:
Noona Ambartsumian, Eugene Lukanidin, Jonathan Sleeman, Per Guldberg, Mariam Grigorian, Hiromi Yanagisawa, Jörg Klingelhöfer, Rune Troelsgaard Pedersen, Mika Frankel, Natascha Cremers, Ulrik Ralfkjær, Henrik Devitt Møller
Supplementary Figures S1-S4; Supplementary Materials and Methods; Supplementary Table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946bf642dd39f813250ed79423152ba7
https://doi.org/10.1158/1541-7786.22518657.v1
https://doi.org/10.1158/1541-7786.22518657.v1
Autor:
Noona Ambartsumian, Eugene Lukanidin, Jonathan Sleeman, Per Guldberg, Mariam Grigorian, Hiromi Yanagisawa, Jörg Klingelhöfer, Rune Troelsgaard Pedersen, Mika Frankel, Natascha Cremers, Ulrik Ralfkjær, Henrik Devitt Møller
The tumor microenvironment is now recognized as a major factor in determining the survival and growth of disseminated tumor cells at potential metastatic sites. Tumor cells send signals to stroma cells and stimulate them to produce factors that in tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e2323b93c721e703aa5809d42fe309
https://doi.org/10.1158/1541-7786.c.6542052.v1
https://doi.org/10.1158/1541-7786.c.6542052.v1
Autor:
Signe Korbo Christiansen, Vibe H. Oestergaard, Michael Lisby, Rune Troelsgaard Pedersen, Irene Gallina
Publikováno v:
Cell Cycle. 15:176-183
Maintenance of genome integrity is crucial to avoid cancer and other genetic diseases. Thus faced with DNA damage, cells mount a DNA damage response to avoid genome instability. The DNA damage response is partially inhibited during mitosis presumably
Publikováno v:
The Journal of Cell Biology
TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis.
Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Repl
Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Repl
Autor:
Michael Lisby, Rune Troelsgaard Pedersen, Susanne Manuela Germann, Vera Schramke, Vibe H. Oestergaard, Nadine Eckert-Boulet, Irene Gallina
Publikováno v:
The Journal of Cell Biology
TopBP1/Dpb11 prevents accumulation of anaphase chromatin bridges by stimulating the Mec1/ATR kinase and suppressing homologous recombination.
DNA anaphase bridges are a potential source of genome instability that may lead to chromosome breakage
DNA anaphase bridges are a potential source of genome instability that may lead to chromosome breakage
Autor:
Simon Bekker-Jensen, Constanze Pentzold, Michael Lisby, Vibe H. Oestergaard, Rune Troelsgaard Pedersen, Arno F. Alpi, Niels Mailand, Silviu Iosif
Publikováno v:
DNA Repair. 11:892-905
The ubiquitylation cascade plays an important role in the recruitment of repair factors at DNA double-strand breaks. The involvement of a growing number of ubiquitin E3 ligases adds to the complexity of the DNA damage-induced ubiquitin signaling. Her
Autor:
Jirina Bartkova, Michael Lisby, Jiri Bartek, Apolinar Maya-Mendoza, Jiri Lukas, Isabel E. Wassing, Sugiko Watanabe, Rune Troelsgaard Pedersen, Robert Strauss, Fumiko Esashi, Vibe H. Oestergaard, Pavel Moudry, Kamila Wolanin, Kenji Watanabe, Miguel Andújar-Sánchez
Publikováno v:
The Journal of Cell Biology
Moudry, P, Watanabe, K, Wolanin, K M, Bartkova, J, Wassing, I E, Watanabe, S, Strauss, R, Pedersen, R T, Østergaard, V H, Lisby, M, Andújar-Sánchez, M, Maya-Mendoza, A, Esashi, F, Lukas, J & Bartek, J 2016, ' TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity ', The Journal of Cell Biology, vol. 212, no. 3, pp. 281-288 . https://doi.org/10.1083/jcb.201507042
Moudry, P, Watanabe, K, Wolanin, K M, Bartkova, J, Wassing, I E, Watanabe, S, Strauss, R, Pedersen, R T, Østergaard, V H, Lisby, M, Andújar-Sánchez, M, Maya-Mendoza, A, Esashi, F, Lukas, J & Bartek, J 2016, ' TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity ', The Journal of Cell Biology, vol. 212, no. 3, pp. 281-288 . https://doi.org/10.1083/jcb.201507042
Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human cancer remain unclear. Here, through an unbiased small interfering RNA screen, we identifie
Autor:
Per Guldberg, Mika Frankel, Henrik Møller, Ulrik Ralfkjær, Hiromi Yanagisawa, Noona Ambartsumian, Rune Troelsgaard Pedersen, Jonathan P. Sleeman, Jörg Klingelhöfer, Eugene Lukanidin, Natascha Cremers, Mariam Grigorian
Publikováno v:
Molecular Cancer Research; Vol 9
The tumor microenvironment is now recognized as a major factor in determining the survival and growth of disseminated tumor cells at potential metastatic sites. Tumor cells send signals to stroma cells and stimulate them to produce factors that in tu