Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rune T. Kidmose"'
Autor:
Poul Nissen, Jonathan Juhl, Rune T. Kidmose, Thomas Boesen, Bjørn Panyella Pedersen, Jesper Lykkegaard Karlsen
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 526-531 (2019)
IUCrJ
Kidmose, R T, Juhl, J, Nissen, P, Boesen, T, Karlsen, J L & Pedersen, B P 2019, ' Namdinator-Automatic molecular dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps ', IUCrJ, vol. 6, no. 4, pp. 526-531 . https://doi.org/10.1107/S2052252519007619
IUCrJ
Kidmose, R T, Juhl, J, Nissen, P, Boesen, T, Karlsen, J L & Pedersen, B P 2019, ' Namdinator-Automatic molecular dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps ', IUCrJ, vol. 6, no. 4, pp. 526-531 . https://doi.org/10.1107/S2052252519007619
A pipeline tool called Namdinator is presented that enables the user to run a molecular dynamics flexible fitting (MDFF) simulation in a fully automated manner, online or locally. This provides a fast and easy way to create suitable initial models fo
Autor:
Maria Szomek, Mikael B. L. Winkler, Bjørn Panyella Pedersen, Daniel Wüstner, Katja Thaysen, Shaun Rawson, Stephen P. Muench, Rune T. Kidmose
Publikováno v:
Winkler, M B L, Kidmose, R T, Szomek, M, Thaysen, K, Rawson, S, Muench, S P, Wüstner, D & Pedersen, B P 2019, ' Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins ', Cell, vol. 179, no. 2, pp. 485-497.e18 . https://doi.org/10.1016/j.cell.2019.08.038
Winkler, M B L, Kidmose, R T, Szomek, M, Thaysen, K, Rawson, S, Muench, S P, Wüstner, D & Pedersen, B P 2019, ' Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins ', Cell, vol. 179, no. 2, e18, pp. 485-497 . https://doi.org/10.1016/j.cell.2019.08.038
Cell 179(2), 485-497.e18 (2019). doi:10.1016/j.cell.2019.08.038
Cell
Winkler, M B L, Kidmose, R T, Szomek, M, Thaysen, K, Rawson, S, Muench, S P, Wüstner, D & Pedersen, B P 2019, ' Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins ', Cell, vol. 179, no. 2, e18, pp. 485-497 . https://doi.org/10.1016/j.cell.2019.08.038
Cell 179(2), 485-497.e18 (2019). doi:10.1016/j.cell.2019.08.038
Cell
Cell 179(2), 485 - 497.e18 (2019). doi:10.1016/j.cell.2019.08.038
Niemann-Pick type C (NPC) proteins are essential for sterol homeostasis, believed to drive sterol integration into the lysosomal membrane before redistribution to other cellular m
Niemann-Pick type C (NPC) proteins are essential for sterol homeostasis, believed to drive sterol integration into the lysosomal membrane before redistribution to other cellular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b31e54e5f45c9b5c2cbf0c969193c96
https://portal.findresearcher.sdu.dk/da/publications/507eaa95-0866-452f-8139-fe75ea6a6837
https://portal.findresearcher.sdu.dk/da/publications/507eaa95-0866-452f-8139-fe75ea6a6837
Autor:
Gregers R. Andersen, Rune T. Kidmose
Publikováno v:
Kidmose, R T & Andersen, G R 2016, ' Interacting with the Human Insulin Receptor ', Structure, vol. 24, no. 3, pp. 351-352 . https://doi.org/10.1016/j.str.2016.02.003
Insulin receptor (IR) signaling is critical to controlling nutrient uptake and metabolism. However, only a low-resolution (3.8 Å) structure currently exists for the IR ectodomain, with some segments ill-defined or unmodeled due to disorder. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bfb8280da7872645e393315197a148
https://pure.au.dk/portal/da/publications/interacting-with-the-human-insulin-receptor(7f9d5e0c-213e-4342-bdae-4b8d3fd5a7d9).html
https://pure.au.dk/portal/da/publications/interacting-with-the-human-insulin-receptor(7f9d5e0c-213e-4342-bdae-4b8d3fd5a7d9).html
Publikováno v:
Nielsen, M H, Kidmose, R T & Jenner, L B 2016, ' Structure of TSA2 reveals novel features of the active-site loop of peroxiredoxins ', Acta crystallographica Section D: Structural biology, vol. 72, no. 1, pp. 158-167 . https://doi.org/10.1107/S2059798315023815
Saccharomyces cerevisiaeTSA2 belongs to the family of typical 2-Cys peroxiredoxins, a ubiquitously expressed family of redox-active enzymes that utilize a conserved peroxidatic cysteine to reduce peroxides. Typical 2-Cys peroxiredoxins have been show
Autor:
Stig U. Andersen, Karen Dybkær, Anna Małolepszy, Trine Juul, Jan-Elo Jørgensen, Gregers R. Andersen, Hans Erik Johnsen, Rune T. Kidmose, Jan T. Rasmussen
Publikováno v:
The Journal of Biological Chemistry
Juul, T, Malolepszy, A, Dybkaer, K, Kidmose, R, Rasmussen, J T, Andersen, G R, Johnsen, H E, Jørgensen, J-E & Andersen, S U 2010, ' The in vivo toxicity of hydroxyurea depends on its direct target catalase ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.M110.103564
Juul, T, Malolepszy, A, Dybkaer, K, Kidmose, R, Rasmussen, J T, Andersen, G R, Johnsen, H E, Jørgensen, J-E & Andersen, S U 2010, ' The in vivo toxicity of hydroxyurea depends on its direct target catalase ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.M110.103564
Udgivelsesdato: 2010-May-7 Hydroxyurea (HU) is a well-tolerated ribonucleotide reductase (RNR) inhibitor effective in HIV, sickle cell disease, and blood cancer therapy. Despite a positive initial response, however, most treated cancers eventually pr
Autor:
Gregers R. Andersen, Sofia Mortensen, Steen V. Petersen, Ágnes Szilágyi, Rune T. Kidmose, Zoltán Prohászka
Publikováno v:
Mortensen, S, Kidmose, R T, Petersen, S V, Szilágy, Á, Prohászka, Z & Andersen, G R 2015, ' Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement ', Journal of Immunology, vol. 194, no. 11, pp. 5488-5496 .
Aarhus University
Aarhus University
Complement component C4 is a central protein in the classical and lectin pathways within the complement system. During activation of complement, its major fragment C4b becomes covalently attached to the surface of pathogens and altered self-tissue, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be2ab32d78855e73e7712865de6b28c
https://pure.au.dk/portal/da/publications/structural-basis-for-the-function-of-complement-component-c4-within-the-classical-and-lectin-pathways-of-complement(fb6f4406-1482-4cba-87e3-e74e099e47d7).html
https://pure.au.dk/portal/da/publications/structural-basis-for-the-function-of-complement-component-c4-within-the-classical-and-lectin-pathways-of-complement(fb6f4406-1482-4cba-87e3-e74e099e47d7).html
Autor:
Søren E. Degn, Rune T. Kidmose, Steffen Thiel, Gregers R. Andersen, Annette G. Hansen, Jens C. Jensenius, Mustafa Tekin, Lisbeth Jensen, Troels R. Kjaer
Publikováno v:
Degn, S E, Kjaer, T R, Kidmose, R T, Jensen, L, Hansen, A G, Tekin, M, Jensenius, J C, Andersen, G R & Thiel, S 2014, ' Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes ', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 37, pp. 13445-13450 . https://doi.org/10.1073/pnas.1406849111
Defining mechanisms governing translation of molecular binding events into immune activation is central to understanding immune function. In the lectin pathway of complement, the pattern recognition molecules (PRMs) mannan-binding lectin (MBL) and fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7b821ee3c3de3b5fcd25deeb77800f
https://pure.au.dk/portal/da/publications/complement-activation-by-liganddriven-juxtaposition-of-discrete-pattern-recognition-complexes(ff76c35b-b03e-415f-8be5-ffa4e392e3e4).html
https://pure.au.dk/portal/da/publications/complement-activation-by-liganddriven-juxtaposition-of-discrete-pattern-recognition-complexes(ff76c35b-b03e-415f-8be5-ffa4e392e3e4).html
Autor:
Steffen Thiel, Nick S. Laursen, Troels R. Kjaer, Lars Sottrup-Jensen, Gregers R. Andersen, Sofia Sirotkina, József Dobó, Laure Yatime, Rune T. Kidmose, Péter Gál
Publikováno v:
Kidmose, R T, Laursen, N S, Dobó, J, Kjaer, T R, Sirotkina, S, Yatime, L, Sottrup-Jensen, L, Thiel, S, Gál, P & Andersen, G R 2012, ' Structural basis for activation of the complement system by component C 4 cleavage ', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 38, pp. 15425-15430 . https://doi.org/10.1073/pnas.1208031109
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (38), pp.15425-15430. ⟨10.1073/pnas.1208031109⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (38), pp.15425-15430. ⟨10.1073/pnas.1208031109⟩
An essential aspect of innate immunity is recognition of molecular patterns on the surface of pathogens or altered self through the lectin and classical pathways, two of the three well-established activation pathways of the complement system. This re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3017cf1ae3d05440c82fb70a1b94be28
https://pure.au.dk/ws/files/81380889/c4m2_pnas_published.pdf
https://pure.au.dk/ws/files/81380889/c4m2_pnas_published.pdf
Autor:
Alexander B. Chetverin, Charlotte R. Knudsen, Gregers R. Andersen, Nikita N. Vasiliev, Rune T. Kidmose
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(24)
The RNA-dependent RNA polymerase core complex formed upon infection of Escherichia coli by the bacteriophage Qβ is composed of the viral catalytic β-subunit as well as the host translation elongation factors EF-Tu and EF-Ts, which are required for
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C1402-C1402
During neuronal development axons are guided by a gradient of the signal molecule netrin, which attracts extending neurons by binding to the DCC (Deleted in Colorectal Cancer) Receptor. It has been shown that the intracellular domain of the DCC recep