Local changes in potassium ions regulate input integration in active dendrites.

Autor: Malthe S Nordentoft, Naoya Takahashi, Mathias S Heltberg, Mogens H Jensen, Rune N Rasmussen, Athanasia Papoutsi

Publikováno v: PLoS Biology, Vol 22, Iss 12, p e3002935 (2024)

During neuronal activity, the extracellular concentration of potassium ions ([K+]o) increases substantially above resting levels, yet it remains unclear what role these [K+]o changes play in the dendritic integration of synaptic inputs. We here used

Externí odkaz: https://doaj.org/article/c60d0dbb7b614c4199f26a5b6595b80d

Biophysical Modeling of Dopaminergic Denervation Landscapes in the Striatum Reveals New Therapeutic Strategy

Autor: Mathias L. Heltberg, Hussein N. Awada, Alessandra Lucchetti, Mogens H. Jensen, Jakob K. Dreyer, Rune N. Rasmussen

Publikováno v: Heltberg, M L, Awada, H N, Lucchetti, A, Jensen, M H, Dreyer, J K & Rasmussen, R N 2022, ' Biophysical Modeling of Dopaminergic Denervation Landscapes in the Striatum Reveals New Therapeutic Strategy ', eNeuro, vol. 9, no. 2 . https://doi.org/10.1523/ENEURO.0458-21.2022

Parkinson's disease (PD) results from a loss of dopaminergic neurons. What triggers the break-down of neuronal signaling, and how this might be compensated, is not understood. The age of onset, progression and symptoms vary between patients, and our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956f53621365875083495e45397d499a
https://doi.org/10.1523/eneuro.0458-21.2022