Zobrazeno 1 - 10 of 48 pro vyhledávání: '"Rune Kleppe"'
1
Akademický článek
The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models
Autor: Hayley J. MacDonald, Rune Kleppe, Peter D. Szigetvari, Jan Haavik
Publikováno v: Frontiers in Psychiatry, Vol 15 (2024)
Multiple lines of evidence indicate that altered dopamine signaling may be involved in neuropsychiatric disorders and common behavioral traits. Here we critically review evidence collected during the past 40-plus years supporting the role of dopamine
Externí odkaz: https://doaj.org/article/9a6e1fa88a604bf19a81125acf23e142
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2
Akademický článek
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
Autor: María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I. Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R. López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M. Valpuesta
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline and noradrenaline. Here, the authors present the cryo-EM structures of full-length human TH in t
Externí odkaz: https://doaj.org/article/3b54c91d09444b37ba25ca02cc815dcd
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3
Akademický článek
Cell Death Inducing Microbial Protein Phosphatase Inhibitors—Mechanisms of Action
Autor: Rune Kleppe, Lars Herfindal, Stein Ove Døskeland
Publikováno v: Marine Drugs, Vol 13, Iss 10, Pp 6505-6520 (2015)
Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death. Their intracellular targets are the major serine/threonine protei
Externí odkaz: https://doaj.org/article/3f9a2986bc16406e8d8997e3ab8fe9a5
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4
Akademický článek
Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.
Autor: Lars Herfindal, Camilla Krakstad, Lene Myhren, Hanne Hagland, Reidun Kopperud, Knut Teigen, Frank Schwede, Rune Kleppe, Stein Ove Døskeland
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94926 (2014)
Analogs of the cyclic nucleotides cAMP and cGMP have been extensively used to mimic or modulate cellular events mediated by protein kinase A (PKA), Exchange protein directly activated by cAMP (Epac), or protein kinase G (PKG). We report here that som
Externí odkaz: https://doaj.org/article/61af7002329d499bb1b38422a66f7f44
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6
Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency
Autor: Jan Haavik, Peter Ruoff, Gyrid Nygaard, Peter D. Szigetvari, Marte I. Flydal, Aurora Martinez, Rune Kleppe, Ann Kari Grindheim
Publikováno v: Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 1186, p 1186 (2021)
Dopa-responsive dystonia (DRD) is a rare movement disorder associated with defective dopamine synthesis. This impairment may be due to the fact of a deficiency in GTP cyclohydrolase I (GTPCHI, GCH1 gene), sepiapterin reductase (SR), tyrosine hydroxyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f804504363c6f877f37c46c37ad4bb10
https://pubmed.ncbi.nlm.nih.gov/34834538
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7
ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications
Autor: Jan Haavik, Helene Barone, Andreas Reif, Rune Kleppe, Nibal Betari, Selina Cannon Homaei
Publikováno v: Neuroscience and Biobehavioral Reviews
Neurometabolic diseases (NMDs) are typically caused by genetic abnormalities affecting enzyme functions, which in turn interfere with normal development and activity of the nervous system. Although the individual disorders are rare, NMDs are collecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17135acd700c5680a9efe7ab1ff65c44
https://hdl.handle.net/11250/2833487
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8
The Structure of Human Tyrosine Hydroxylase Reveals the Mechanism for Feedback Inhibition by Dopamine
Autor: Knut Teigen, José Ramón López-Blanco, Pablo Chacón, Jorge Cuéllar, Rune Kleppe, Aurora Martinez, César Santiago, Marte I. Flydal, José M. Valpuesta, Trond-André Kråkenes, Sara Alvira, Teresa Bueno-Carrasco
Tyrosine hydroxylase (TH) is a highly regulated enzyme that catalyses the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines. Mutations and dysfunction in this enzyme lead to DA deficiency and parkinsonisms of different
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03a8c8befef21a868f87c0a99aa3f0d4
https://doi.org/10.21203/rs.3.rs-64971/v1
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9
Involvement of the 14-3-3 Gene Family in Autism Spectrum Disorder and Schizophrenia: Genetics, Transcriptomics and Functional Analyses
Autor: Jan Haavik, Christine M. Freitag, Amaia Hervás, Estefanía Moreno, Janice M. Fullerton, Andreas Reif, Rune Kleppe, Bru Cormand, Andreas G. Chiocchetti, Eva Rojo-Francàs, Bàrbara Torrico, Nanda Rommelse, Vicent Casadó, Barbara Franke, Sadaf Ghorbani, Claudio Toma, Jan K. Buitelaar, Noèlia Fernàndez-Castillo, Ester Antón-Galindo, Isabel Rueda, Laura Pineda-Cirera
Publikováno v: Journal of Clinical Medicine; Volume 9; Issue 6; Pages: 1851
Journal of Clinical Medicine, Vol 9, Iss 1851, p 1851 (2020)
Journal of Clinical Medicine
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Clinical Medicine, 9
Journal of Clinical Medicine, 9, 6
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
The 14-3-3 protein family are molecular chaperones involved in several biological functions and neurological diseases. We previously pinpointed YWHAZ (encoding 14-3-3ζ) as a candidate gene for autism spectrum disorder (ASD) through a whole-exome seq
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397f75a3ab4ed7b3e28542c478b93ef8
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10
GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production
Autor: Hrvoje Miletic, Jan Haavik, Petri Kursula, Elaheh Mahootchi, Christian Totland, Roberto Megias-Perez, Rune Kleppe, Selina Cannon Himaei, Jeffrey C. Glennon, Floriana Mogavero, Ingeborg Winge, Tor-Arne Hegvik, Anne Baumann
Publikováno v: eabb3713
6:eabb3713
Science Advances
Science Advances, 6, 29
Science Advances, 6
Mice lacking the enzyme GADL1 have reduced levels of carnosine and anserine peptides and increased oxidative stress markers.
Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neurom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34495a852ab46fae6a37663d04842020
https://hdl.handle.net/11250/2736451
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