Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rune Johansen Forstrøm"'
Autor:
Synnøve Brandt Ræder, Kirsten Skarstad, Aina Nedal, Emily Helgesen, Magnar Bjørås, Balagra Kasim Sumabe, Jacob H. Martinsen, Bjørn Dalhus, Birthe B. Kragelund, Marit Otterlei, Kim Lindland, Rune Johansen Forstrøm
Publikováno v:
Nucleic Acids Research
Nedal, A, Ræder, S B, Dalhus, B, Helgesen, E, Forstrøm, R J, Lindland, K, Sumabe, B K, Martinsen, J H, Kragelund, B B, Skarstad, K, Bjørås, M & Otterlei, M 2020, ' Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis ', Nucleic Acids Research, vol. 48, no. 10, pp. 5540-5554 . https://doi.org/10.1093/nar/gkaa278
Nedal, A, Ræder, S B, Dalhus, B, Helgesen, E, Forstrøm, R J, Lindland, K, Sumabe, B K, Martinsen, J H, Kragelund, B B, Skarstad, K, Bjørås, M & Otterlei, M 2020, ' Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis ', Nucleic Acids Research, vol. 48, no. 10, pp. 5540-5554 . https://doi.org/10.1093/nar/gkaa278
In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, share a C-terminal hydrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1166f160e0f70964f9dd1e874599634
https://hdl.handle.net/11250/2679696
https://hdl.handle.net/11250/2679696
Autor:
Alexander D. Rowe, Ingrun Alseth, Ida Rosnes, Erik Sebastian Vik, Bjørn Dalhus, Rune Johansen Forstrøm, Magnar Bjørås
Publikováno v:
Structure. 21(2):257-265
Summary The DNA repair enzyme endonuclease V (EndoV) recognizes and cleaves DNA at deaminated adenine lesions (hypoxanthine). In addition, EndoV cleaves DNA containing various helical distortions such as loops, hairpins, and flaps. To understand the
Autor:
Bjørn Dalhus, Rune Johansen Forstrøm, Joy L. Huffman, John A. Tainer, Line Brennhaug Nilsen, Hanne Korvald, Ingrun Alseth, Magnar Bjørås, Cynthia T. McMurray
Publikováno v:
Structure. 21(1):154-166
SummaryModifications and loss of bases are frequent types of DNA lesions, often handled by the base excision repair (BER) pathway. BER is initiated by DNA glycosylases, generating abasic (AP) sites that are subsequently cleaved by AP endonucleases, w
Publikováno v:
Nucleic Acids Research
Abasic (AP) sites are formed spontaneously and are inevitably intermediates during base excision repair of DNA base damages. AP sites are both mutagenic and cytotoxic and key enzymes for their removal are AP endonucleases. However, AP endonuclease in
Autor:
Rune Johansen Forstrøm, Magnar Bjørås, Monika Forsbring, Ina Høydal Helle, Ingrun Alseth, Erik Sebastian Vik, Paul Hoff Backe, Bjørn Dalhus
Publikováno v:
Structure. 19:117-127
Summary7,8-Dihydro-8-oxoguanine (8oxoG) is a major mutagenic base lesion formed when reactive oxygen species react with guanine in DNA. The human 8oxoG DNA glycosylase (hOgg1) recognizes and initiates repair of 8oxoG. hOgg1 is acknowledged as a bifun
Autor:
Pia Øistad Osenbroch, Lars Eide, Rune Johansen Forstrøm, Janne Strand, Ruth Halsne, Ingrid van der Pluijm, Pia Auk-Emblem
Publikováno v:
FEBS Journal, 276(10), 2811-2821. Wiley-Blackwell Publishing Ltd
Cockayne syndrome (CS) is a complex, progressive disease that involves neurological and developmental impairment and premature aging. The majority of CS patients have mutations in the CSB gene. The CSB protein is involved in multiple DNA repair pathw
Autor:
Christine G. Neurauter, Arne Yndestad, Luisa Luna, Lars Eide, Rune Johansen Forstrøm, Magnar Bjørås, Pål Aukrust, Erik Øie, Leif Erik Vinge
Publikováno v:
Mutation research. 666(1-2)
Base excision repair (BER) is the major pathway to counteract the genotoxic effect of endogenous DNA damaging agents. The present study investigated the enzymatic activities and gene transcription of DNA glycosylases initiating BER in an experimental