Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Runduo Liu"'
Autor:
Lin Cheng, Zhuang Miao, Sicen Liu, Zhe Li, Hong Fu, Chanjuan Xu, Shilong Hu, Chang Zhao, Yuxuan Liu, Tiantian Zhao, Wencheng Liu, Heli Wang, Runduo Liu, Wei Yan, Xiangdong Tang, Jianfeng Liu, Zhenhua Shao, Bowen Ke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Delta opioid receptor (δOR) plays a pivotal role in modulating human sensation and emotion. It is an attractive target for drug discovery since, unlike Mu opioid receptor, it is associated with low risk of drug dependence. Despite its poten
Externí odkaz:
https://doaj.org/article/cb33bcfa1c674c8684c73a0815c0c282
Autor:
Deyan Wu, Xuehua Zheng, Runduo Liu, Zhe Li, Zan Jiang, Qian Zhou, Yue Huang, Xu-Nian Wu, Chen Zhang, Yi-You Huang, Hai-Bin Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1351-1362 (2022)
Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organic and medicinal chemistry. However, most approache
Externí odkaz:
https://doaj.org/article/35e8bd3e764c47488baa224bfba360df
Autor:
Mingfu Wen, Yueqian Du, Runduo Liu, Zeqin Li, Longshi Rao, Hongwei Xiao, Yi Ouyang, Xiaodong Niu
Publikováno v:
Frontiers in Materials, Vol 9 (2022)
Magnetorheological fluids (MRFs) are a class of smart magnetic controlled materials whose rheological properties can be controlled by a magnetic field. These materials have advantages of short response time, high dynamic range and low energy consumpt
Externí odkaz:
https://doaj.org/article/fe5f2341fbf24b369ce05b4361aaac14
Publikováno v:
Journal of Chemical Information and Modeling. 63:561-570
Free energy perturbation-relative binding free energy (FEP-RBFE) prediction has shown its reliability and accuracy in the prediction of protein-ligand binding affinities, which plays a fundamental role in structure-based drug design. In FEP-RBFE pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7291f3baf2b28645dba1b524c622fc
https://doi.org/10.1021/acs.jcim.2c01076
https://doi.org/10.1021/acs.jcim.2c01076
Autor:
Zhe Li, Chengkun Wu, Yishui Li, Runduo Liu, Kai Lu, Ruibo Wang, Jie Liu, Chunye Gong, Canqun Yang, Xin Wang, Chang-Guo Zhan, Hai-Bin Luo
Publikováno v:
The International Journal of High Performance Computing Applications. 37:45-57
As a theoretically rigorous and accurate method, FEP-ABFE (Free Energy Perturbation-Absolute Binding Free Energy) calculations showed great potential in drug discovery, but its practical application was difficult due to high computational cost. To ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32a32dc7f217f13675b5ff1f7539153c
https://doi.org/10.1177/10943420221117797
https://doi.org/10.1177/10943420221117797
Autor:
Zhe Li, Runduo Liu, Hai-Bin Luo, Chen Zhang, Deyan Wu, Zan Jiang, Qian Zhou, Xu-Nian Wu, Yue Huang, Xuehua Zheng, Yi-You Huang
Publikováno v:
Acta Pharmaceutica Sinica B. 12:1351-1362
Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organic and medicinal chemistry. However, most approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2432a1f72d43ab23108f17870f202c77
https://doi.org/10.1016/j.apsb.2021.09.027
https://doi.org/10.1016/j.apsb.2021.09.027
Autor:
Liang Ji, Xinguang Zhou, Runduo Liu, Liming Wang, Yuanyuan Hu, Jinyu Gu, Zhe Li, Chenglin Li, Tonghui Huang, Yanyan Yu
Publikováno v:
Sensors and Actuators B: Chemical. 380:133415
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df9dbf8ea6889371ede00ce060220c92
https://doi.org/10.1016/j.snb.2023.133415
https://doi.org/10.1016/j.snb.2023.133415
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Behnam and Klein (1) carried out in vitro assays on two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors, including atazanavir reported by us (2), using an Mpro protein with C-terminal His-tag under various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd7cb9f77187fbfeff506774c77b188
https://doi.org/10.1073/pnas.2108209118
https://doi.org/10.1073/pnas.2108209118
Autor:
Cheng Tian, Guangzhong Liang, Chunyi Wang, Ruikai He, Keni Ning, Zhe Li, Runduo Liu, Yan Ma, Shixia Guan, Jiewei Deng, Junqiu Zhai
Publikováno v:
Biosensors and Bioelectronics. 211:114360
In situ imaging of DNA repair enzymes in living cells gives important insights to diagnosis and explore the formation of various diseases. Fluorescent probes have become a powerful and widely used technique for their high sensitivity and real-time ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf085fddb93fb4d8730df1a08aae23ad
https://doi.org/10.1016/j.bios.2022.114360
https://doi.org/10.1016/j.bios.2022.114360
Autor:
Zhe Li, Ling Huang, Chen Zhang, Lei Guo, Ju Huang, Runduo Liu, Hai-Bin Luo, Qian Zhou, Lehui Xiao, Sirui Zhang, Deyan Wu, Yinuo Wu, Yuqi Gao, Yi-You Huang
Publikováno v:
ACS chemical biology. 16(5)
A challenge for sensors targeting specific enzymes of interest in their native environment for direct imaging is that they rationally exploit a highly selective fluorescent probe with a high binding affinity to provide real-time detection. Immunohist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58bfcfb6068e9e1bba5b683e79bac4c
https://pubmed.ncbi.nlm.nih.gov/33955736
https://pubmed.ncbi.nlm.nih.gov/33955736