Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Run-Duo Gao"'
Autor:
Sadakatali S. Gori, Ajit G. Thomas, Arindom Pal, Robyn Wiseman, Dana V. Ferraris, Run-duo Gao, Ying Wu, Jesse Alt, Takashi Tsukamoto, Barbara S. Slusher, Rana Rais
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2018 (2022)
Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of active-site GCPII inhibitors makes them highly charged, manifesting poor pharmacokinetic (PK) pr
Externí odkaz:
https://doaj.org/article/8dd66acf64054ef395a30b21fda30f08
Autor:
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S. Gori, Heather M. LaPorte, Maxime A. Siegler, Janet L. Neisewander, Robert H. Mach, Meharvan Singh, Barbara S. Slusher, Rana Rais, Robert R. Luedtke, Takashi Tsukamoto
Publikováno v:
ACS Chemical Neuroscience. 14:947-957
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91591ff9ef92ee2ce309b777ad784cfb
https://doi.org/10.1021/acschemneuro.2c00791
https://doi.org/10.1021/acschemneuro.2c00791
Autor:
Run-Duo Gao, Masahiro Maeda, Carolyn Tallon, Andrew P. Feinberg, Barbara S. Slusher, Takashi Tsukamoto
Publikováno v:
ACS medicinal chemistry letters. 13(12)
In the search for alternatives to 6-aminonicotinamide (6AN), a series of 6-aminonicotinic acid esters were designed and synthesized as precursors of 6-amino-NADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f614d4973735417cb1c0f58888956a78
https://pubmed.ncbi.nlm.nih.gov/36518700
https://pubmed.ncbi.nlm.nih.gov/36518700
Publikováno v:
Chemical Science
The palladium-catalysed tandem aza-Heck–Suzuki and aza-Heck–carbonylation reactions of O-phenyl hydroxamic ethers are reported. These formal alkene carboamination reactions provide highly versatile access to wide range complex, stereogenic second
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5099b14b4309898fac184d7c4818366
http://europepmc.org/articles/PMC8246078
http://europepmc.org/articles/PMC8246078
Autor:
Arindom Pal, Barbara S. Slusher, Jenny Lam, Eva Prchalova, Run-Duo Gao, Rana Rais, Niyada Hin, Takashi Tsukamoto
Publikováno v:
Bioorg Med Chem Lett
Two distinct diazo precursors, imidazotetrazine and nitrous amide, were explored as promoieties in designing prodrugs of 6-diazo-5-oxo-l-norleucine (DON), a glutamine antagonist. As a model for an imidazotetrazine-based prodrug, we synthesized (S)-2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f31284a499def3028a4e3df6ffd8b33
https://europepmc.org/articles/PMC8607733/
https://europepmc.org/articles/PMC8607733/
Publikováno v:
Chemistry – A European Journal. 25:4330-4334
An intermolecular asymmetric cascade dearomatization reaction of indole derivatives with propargyl carbonate was developed. The challenges associated with both the chemoselectivity between the carbon and nitrogen nucleophile and the enantioselective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7741b764ad620804d5d63c874711c5
https://doi.org/10.1002/chem.201900425
https://doi.org/10.1002/chem.201900425
Autor:
Rachel Shannon Helms, Chirag H. Patel, Robert D. Leone, Bridget Duvall, Run-Duo Gao, Takashi Tsukamoto, Barbara S. Slusher, Joel L. Pomerantz, Jonathan D Powell
Publikováno v:
The Journal of Immunology. 208:169.18-169.18
We sought to evaluate PAS domain containing kinase (PASK) inhibition during T cell differentiation using the previously described PASK inhibitor BioE-1197. Notably, CD8+, Th1, and Th2 T cells activated and expanded in the presence of BioE-1197 displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b71c1c7f93d6ce927c29a11af8432b8
https://doi.org/10.4049/jimmunol.208.supp.169.18
https://doi.org/10.4049/jimmunol.208.supp.169.18
Publikováno v:
Organic Chemistry Frontiers. 5:1664-1669
A palladium-catalyzed intermolecular dearomatic allenylation of hydrocycloalk[b]indoles with 2,3-allenyl carbonates has been developed, providing access to functionalized allenes containing an indoline unit under optimized conditions. Both terminal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c6b83cad76beeb30b030932c5c373ef
https://doi.org/10.1039/c8qo00163d
https://doi.org/10.1039/c8qo00163d
Publikováno v:
Chemistry - A European Journal. 22:11601-11604
Bridged indoline derivatives were synthesized by an intermolecular Pd-catalyzed allylic dearomatization reaction of substituted indoles. The reaction between indoles and allyl carbonates bearing a nucleophilic alcohol side-chain proceeds in a cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e80b0fc2646008763e06abff701639a
https://doi.org/10.1002/chem.201602691
https://doi.org/10.1002/chem.201602691
Autor:
Rana Rais, Barbara S. Slusher, Vijayabhaskar Veeravalli, Anne Le, Run-Duo Gao, Bridget Duvall, Ajit G. Thomas, Amira Elgogary, Takashi Tsukamoto, Camilo Rojas, Sarah C. Zimmermann, Filip Kalčic
Publikováno v:
Bioorg Med Chem
A series of allosteric kidney-type glutaminase (GLS) inhibitors possessing a mercaptoethyl (-SCH(2)CH(2)-) linker were synthesized in an effort to further expand the structural diversity of chemotypes derived from bis-2-(5-phenylacetamido-1,3,4-thiad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25f973dcc7b5fdc64a0ba8e565b4d8e
https://doi.org/10.1016/j.bmc.2020.115698
https://doi.org/10.1016/j.bmc.2020.115698