Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease

Autor: Lebender, LF, Prünte, L, Rumzhum, NN, Ammit, AJ

© 2018 Elsevier Ltd Arachidonic acid is metabolized by cyclooxygenases (COX-1 and COX-2) into various prostanoids which exert different functions in mammalian physiology. One of these prostanoids, prostaglandin E 2 (PGE 2 ), interacts with four diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::22238b88322af15ca2613b05b7790aeb
https://hdl.handle.net/10453/122339

IL-17A increases TNF-α-induced COX-2 protein stability and augments PGE2 secretion from airway smooth muscle cells: Impact on β2-adrenergic receptor desensitization

Autor: Rumzhum, NN, Patel, BS, Prabhala, P, Gelissen, IC, Oliver, BG, Ammit, AJ

© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Background IL-17A plays an important role in respiratory disease and is a known regulator of pulmonary inflammation and immunity. Recent studies have linked IL-17A with exacerbation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::50e379df58cff61578e83c7769ac3957
https://hdl.handle.net/10453/41773

TLR2 activation causes tachyphylaxis to β2-Agonists in vitro and ex vivo: Modelling bacterial exacerbation

Autor: Alkhouri, H, Rumzhum, NN, Rahman, MM, Fitzpatrick, M, De Pedro, M, Oliver, BG, Bourke, JE, Ammit, AJ

Background Asthma is a widespread chronic health problem exacerbated by common viral and bacterial infections. Further research is required to understand how infection worsens asthma control in order to advance therapeutic options in the future. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::2e44573a9e8f023d167b671ab0b9388d
https://hdl.handle.net/10453/115527

EP 2 and EP 4 receptor antagonists: Impact on cytokine production and β 2 -adrenergic receptor desensitization in human airway smooth muscle.

Autor: Bradbury P; Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia., Rumzhum NN; Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia., Ammit AJ; Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.

Publikováno v: Journal of cellular physiology [J Cell Physiol] 2019 Jul; Vol. 234 (7), pp. 11070-11077. Date of Electronic Publication: 2018 Dec 07.

TLR2 ligation induces corticosteroid insensitivity in A549 lung epithelial cells: Anti-inflammatory impact of PP2A activators.

Autor: Rahman MM; Faculty of Pharmacy, University of Sydney, NSW, Australia., Prabhala P; Faculty of Pharmacy, University of Sydney, NSW, Australia., Rumzhum NN; Faculty of Pharmacy, University of Sydney, NSW, Australia., Patel BS; Faculty of Pharmacy, University of Sydney, NSW, Australia., Wickop T; Faculty of Pharmacy, University of Sydney, NSW, Australia., Hansbro PM; Priority Research Centre for Respiratory Diseases, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia., Verrills NM; School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, NSW, Australia., Ammit AJ; Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, NSW, Australia; School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, Australia. Electronic address: Alaina.Ammit@uts.edu.au.

Publikováno v: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2016 Sep; Vol. 78, pp. 279-287. Date of Electronic Publication: 2016 Jul 28.